Search Results - "de Bruin, T. W. A."

Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study by Corpeleijn, E, Feskens, E.J.M, Jansen, E.H.J.M, Mensink, M, Saris, W.H.M, Bruin, T.W.A. de, Blaak, E.E

“…The aim of this study was to investigate whether lifestyle intervention-induced changes in serum fatty acid profile of cholesteryl esters and estimated…”
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Twice-daily dapagliflozin co-administered with metformin in type 2 diabetes: a 16-week randomized, placebo-controlled clinical trial by Schumm-Draeger, P.-M., Burgess, L., Korányi, L., Hruba, V., Hamer-Maansson, J. E., de Bruin, T. W. A.

“…Aims To evaluate the efficacy and safety of twice‐daily dosing of dapagliflozin and metformin, exploring the feasibility of a fixed‐dose combination. Methods…”
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Long-term maintenance of efficacy of dapagliflozin in patients with type 2 diabetes mellitus and cardiovascular disease by Leiter, L. A., Cefalu, W. T., de Bruin, T. W. A., Xu, J., Parikh, S., Johnsson, E., Gause-Nilsson, I.

“…Aim To evaluate the long‐term efficacy, safety and tolerability of dapagliflozin versus placebo added to usual care in patients with type 2 diabetes mellitus…”
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Dapagliflozin twice daily or once daily: effect on pharmacokinetics and urinary glucose excretion in healthy subjects by Tang, W., Reele, S., Hamer-Maansson, J. E., Parikh, S., de Bruin, T. W. A.

“…The primary objective of this single‐centre, open‐label crossover study (NCT01072578) was to assess the effect of dapagliflozin on the amount of glucose in the…”
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Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance by MENSINK, M, BLAAK, E. E, VIDAL, H, DE BRUIN, T. W. A, GLATZ, J. F. C, SARIS, W. H. M

“…Skeletal muscle of pre-diabetic patients is characterised by a diminished capacity to handle fatty acids. A diminished content of several enzymes involved in…”
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Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance by Corpeleijn, E., Van Der Kallen, C. J. H., Kruijshoop, M., Magagnin, M. G. P., De Bruin, T. W. A., Feskens, E. J. M., Saris, W. H. M., Blaak, E. E.

“…Aims  The membrane‐bound fatty acid transporter CD36/FAT may play a role in disturbed fatty acid handling as observed in the metabolic syndrome and Type 2…”
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Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses by Van Dam, R. M., Hoebee, B., Seidell, J. C., Schaap, M. M., De Bruin, T. W. A., Feskens, E. J. M.

“…To evaluate the relation between common variants in the ATP-sensitive K+ channel genes and glucose intolerance. We conducted a meta-analysis of reported…”
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Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year by Mensink, M, Feskens, E.J.M, Saris, W.H.M, Bruin, T.W.A. de, Blaak, E.E

“…AIMS: Important risk factors for the progression from impaired glucose tolerance to type II diabetes mellitus are obesity, diet and physical inactivity. The…”
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Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus by Van Greevenbroek, M. M. J., Vermeulen, V. M. M-J., Feskens, E. J. M., Evelo, C. T., Kruijshoop, M., Hoebee, B., Van Der Kallen, C. J. H., De Bruin, T. W. A.

“…Aims  Thioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic dyslipidaemia, since TXNIP is the strongest…”
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A proposal to redefine familial combined hyperlipidaemia - Third workshop on FCHL held in Barcelona from 3 to 5 May 2001, during the Scientific Sessions of the European Society for Clinical Investigation by Sniderman, A. D., Castro Cabezas, M., Ribalta, J., Carmena, R., De Bruin, T. W. A., De Graaf, J., Erkelens, D. W., Humphries, S. E., Masana, L., Real, J. T., Talmud, P. J., Taskinen, M. R.

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Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study by Brouwers, M. C. G. J., Dekker, J. M., Van Greevenbroek, M. M. J., Van Der Kallen, C. J. H., Heine, R. J., De Bruin, T. W. A., Stehouwer, C. D. A.

“…Aims  Low‐density lipoprotein cholesterol (LDL‐C) levels are often fairly normal in Type 2 diabetes mellitus (DM). We anticipated that a parabolic relation…”
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Subscapular skinfold thickness distinguishes between transient and persistent impaired glucose tolerance: Study on Lifestyle-Intervention and Impaired Glucose Tolerance Maastricht (SLIM) by Mensink, M., Feskens, E. J. M., Kruijshoop, M., De Bruin, T. W. A., Saris, W. H. M., Blaak, E. E.

“…Aims To assess whether adding anthropometric measurements to an oral glucose tolerance test (OGTT) can help to distinguish between transient and persistent…”
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Delayed chylomicron remnant clearance in subjects with heterozygous familial hypercholesterolaemia by Castro Cabezas, M., DE Bruin, T. W. A., Westerveld, H. E., Meijer, E., Erkelens, D. W.

“…Castro Cabezas M, De Bruin TWA, Westerveld HE, Meijer E, Erkelens DW (Departments of Internal Medicine and Endocrinology, University Hospital Utrecht and…”
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Disrupted co-ordination of Pax-8 and thyroid transcription factor-1 gene expression in a dedifferentiated rat thyroid tumour cell line derived from FRTL-5 by van der Kallen, C J, Spierings, D C, Thijssen, J H, Blankenstein, M A, de Bruin, T W

“…The mutant rat thyroid cell line FRTL-5/TA, isolated from a non-functional tumour which originated spontaneously from wild-type FRTL-5 cells, shows autonomous…”
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Limitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves' disease by VAN DER HEIJDEN, J. H. W, DE BRUIN, T. W. A, GLAUDEMANS, K. A. F. M, DE KRUIF, J, BANGA, J. P, LOGTENBERG, T

“…Graves' disease (GD) is characterized by the presence of autoantibodies against the TSH‐receptor (TSH‐R) which are pathogenic and, upon binding to the…”
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Triglyceride-rich lipoproteins in non-insulin-dependent diabetes mellitus: post-prandial metabolism and relation to premature atherosclerosis by De Man, F H, Cabezas, M C, Van Barlingen, H H, Erkelens, D W, de Bruin, T W

“…Non-insulin-dependent diabetes mellitus is frequently associated with premature atherosclerosis. Abnormalities in lipid and lipoprotein metabolism contribute…”
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Subclasses of Low-Density Lipoprotein and Very Low-Density Lipoprotein in Familial Combined Hyperlipidemia: Relationship to Multiple Lipoprotein Phenotype by Georgieva, A.M, van Greevenbroek, M.M.J, Krauss, R.M, Brouwers, M.C.G.J, Vermeulen, V.M.M.-J, Robertus-Teunissen, M.G, van der Kallen, C.J.H, de Bruin, T.W.A

“…OBJECTIVE—The present study addresses the presence of distinct metabolic phenotypes in familial combined hyperlipidemia (FCHL) in relation to small dense…”
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Thyrotrophin receptors in normal and neoplastic (primary and metastatic) canine thyroid tissue by Verschueren, C P, Rutteman, G R, Vos, J H, Van Dijk, J E, de Bruin, T W

“…Thyrotrophin (TSH) is the conditional growth factor of thyroid epithelial cells. Abnormalities in TSH-receptor binding such as a low receptor number or low…”
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Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A by Kallen, C.J.H. van der, Cantor, R.M, Greevenbroek, M.M.J. van, Geurts, J.M.W, Bouwman, F.G, Aouizerat, B.E, Allayee, H, Buurman, W.A, Lusis, A.J, Rotter, J.I

“…OBJECTIVE: To search for novel genes contributing to adiposity in familial combined hyperlipidemia (FCH), a disorder characterized by abdominal obesity,…”
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Standardized radioiodine therapy in Graves' disease: the persistent effect of thyroid weight and radioiodine uptake on outcome by de Bruin, T W, Croon, C D, de Klerk, J M, van Isselt, J W

“…To assess the incidence of hypothyroidism, euthyroidism, and recurrent hyperthyroidism following a standard dose of Na131I (3.7 MBq or 100 microCi) per g…”
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