Search Results - "de Bruin, René J. A"

Prorenin Accumulation and Activation in Human Endothelial Cells: Importance of Mannose 6-Phosphate Receptors by van den Eijnden, Mark M.E.D, Saris, Jasper J, de Bruin, René J.A, de Wit, Elly, Sluiter, Wim, Reudelhuber, Timothy L, Schalekamp, Maarten A.D.H, Derkx, Frans H.M, Danser, A.H Jan

“…ABSTRACT—ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation…”
Get full text

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor by Batenburg, Wendy W, Krop, Manne, Garrelds, Ingrid M, de Vries, René, de Bruin, René JA, Burcklé, Celine A, Müller, Dominik N, Bader, Michael, Nguyen, Geneviève, Danser, AH Jan

“…OBJECTIVEMannose 6-phosphate receptors (M6PR) bind both renin and prorenin, and such binding contributes to renin/prorenin clearance but not to angiotensin…”
Get full text

High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin by Saris, J J, Derkx, F H, De Bruin, R J, Dekkers, D H, Lamers, J M, Saxena, P R, Schalekamp, M A, Jan Danser, A H

“…Mannose-6-phosphate (man-6-P)/insulin-like growth factor-II (man-6-P/IgF-II) receptors are involved in the activation of recombinant human prorenin by…”
Get more information

Transendothelial transport of renin–angiotensin system components by van den Eijnden, Mark M. E. D, de Bruin, René J. A, de Wit, Elly, Sluiter, Wim, Deinum, Jaap, Reudelhuber, Timothy L, Danser, A H. Jan

“…BACKGROUND Vascular (interstitial) angiotensin (ANG) II production depends on circulating renin–angiotensin system (RAS) components. Mannose 6-phosphate…”
Get full text

Different contributions of the angiotensin-converting enzyme C-domain and N-domain in subjects with the angiotensin-converting enzyme II and DD genotype by van Esch, Joep HM, van Gool, Jeanette MG, de Bruin, René JA, Payne, John R, Montgomery, Hugh E, Hectors, Magda, Deinum, Jaap, Dive, Vincent, Jan Danser, AH

“…BACKGROUNDAngiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in…”
Get full text

Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a biomarker of cardiac filling pressures in pre-eclampsia by Speksnijder, Leonie, Rutten, Joost H.W, van den Meiracker, Anton H, de Bruin, René J.A, Lindemans, Jan, Hop, Wim C.J, Visser, Willy

“…Abstract Objective To evaluate if amino-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels reflect intracardiac filling pressures in…”
Get full text

Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells by Batenburg, Wendy W, de Bruin, René J.A, van Gool, Jeanette M.G, Müller, Dominik N, Bader, Michael, Nguyen, Geneviève, Jan Danser, A H

“…OBJECTIVE—Renin inhibition with aliskiren has been reported to cause a greater rise in renin than other types of renin-angiotensin system blockade, thereby…”
Get full text

Aliskiren Accumulates in Renin Secretory Granules and Binds Plasma Prorenin by Krop, Manne, Garrelds, Ingrid M, de Bruin, René J.A, van Gool, Jeanette M.G, Fisher, Naomi D.L, Hollenberg, Norman K, Danser, A H. Jan

“…The vascular effects of aliskiren last longer than expected based on its half life, and this renin inhibitor has been reported to cause a greater renin rise…”
Get full text

Cardiac Renin Levels Are Not Influenced by the Amount of Resident Mast Cells by Krop, Manne, van Veghel, Richard, Garrelds, Ingrid M, de Bruin, René J.A, van Gool, Jeanette M.G, van den Meiracker, Anton H, Thio, Marco, van Daele, Paul L.A, Danser, A H. Jan

“…To investigate whether mast cells release renin in the heart, we studied renin and prorenin synthesis by such cells, using the human mast cell lines human…”
Get full text