Diagnostic accuracy of interleukin-6, interleukin-10 and tumor necrosis factor alpha cytokine levels in patients with mild cognitive impairment: systematic review and meta-analysis

There is growing evidence suggesting an association between neurodegeneration and inflammation playing a role in the pathogenesis of age-associated diseases, including Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). A systematic review and meta-analysis were performed to verify ev...

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Published in:	Dementia & neuropsychologia Vol. 18; p. e20230027
Main Authors:	de Aquino, Alana Mara Inácio, Gomes, Kedma Anne Lima, de Brito, Letícia Lorena Melo, de Lima, Luciana Domingos, Gomes, Eneas Ricardo de Morais, Andrade, Suellen Mary Marinho Dos Santos
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 2024 Associação Neurologia Cognitiva e do Comportamento
Subjects:	CLINICAL NEUROLOGY Cognitive Dysfunction GERIATRICS & GERONTOLOGY HEALTH CARE SCIENCES & SERVICES Inflammation Interleukins MEDICINE, GENERAL & INTERNAL NURSING PSYCHIATRY PSYCHOLOGY Tumor Necrosis Factor-alpha View & Review Cognitive Dysfunction Inflammation Interleukins Tumor Necrosis Factor-alpha Disfunção Cognitiva Fator de Necrose Tumoral alfa Inflamação Interleucinas
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Summary:	There is growing evidence suggesting an association between neurodegeneration and inflammation playing a role in the pathogenesis of age-associated diseases, including Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). A systematic review and meta-analysis were performed to verify evidence on the diagnostic accuracy parameters of the inflammatory cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α). A search of Medical Literature Analysis and Retrieval System Online (Medline), Scientific Electronic Library Online (SciELO), Web of Science and Science Direct databases was performed and nine observational studies associated with peripheral inflammatory biomarkers in MCI were identified. Mean (±standard deviation - SD) concentrations of these biomarkers and values of true positives, true negatives, false positives and false negatives for MCI and healthy controls (HC) were extracted from these studies. Significantly higher levels of IL-10 were observed in subjects in the MCI group and Mini-Mental State Examination (MMSE) scores were lower compared to HC. For the other investigations, no differences were found between the groups. Our meta-analysis for the TNF-α biomarker revealed high heterogeneity between studies in terms of sensitivity and specificity. These findings do not support the involvement of inflammatory biomarkers for detection of MCI, although significant heterogeneity was observed. More studies are needed to evaluate the role of these cytokines in MCI, as well as in other stages of cognitive decline and all-cause dementias.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Disclosure: There is no conflict of interest to declare.
ISSN:	1980-5764 1980-5764 2764-4863
DOI:	10.1590/1980-5764-DN-2023-0027