Search Results - "de Boer, Peter"

Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study by Cattaneo, Annamaria, Ferrari, Clarissa, Turner, Lorinda, Mariani, Nicole, Enache, Daniela, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, McLaughlin, Anna P., Nettis, Maria A., Nikkheslat, Naghmeh, Sforzini, Luca, Worrell, Courtney, Zajkowska, Zuzanna, Cattane, Nadia, Lopizzo, Nicola, Mazzelli, Monica, Pointon, Linda, Cowen, Philip J., Cavanagh, Jonathan, Harrison, Neil A., de Boer, Peter, Jones, Declan, Drevets, Wayne C., Mondelli, Valeria, Bullmore, Edward T., Pariante, Carmine M.

“…The mRNA expression signatures associated with the ‘pro-inflammatory’ phenotype of depression, and the differential signatures associated with depression…”
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No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing by Cole, John J., McColl, Alison, Shaw, Robin, Lynall, Mary-Ellen, Cowen, Philip J., de Boer, Peter, Drevets, Wayne C., Harrison, Neil, Pariante, Carmine, Pointon, Linda, Goodyear, Carl, Bullmore, Edward, Cavanagh, Jonathan

“…The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation…”
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Reduced Reward Learning Predicts Outcome in Major Depressive Disorder by Vrieze, Elske, Pizzagalli, Diego A, Demyttenaere, Koen, Hompes, Titia, Sienaert, Pascal, de Boer, Peter, Schmidt, Mark, Claes, Stephan

“…Background Reduced reward learning might contribute to the onset and maintenance of major depressive disorder (MDD). In particular, the inability to utilize…”
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Dimensions in major depressive disorder and their relevance for treatment outcome by Vrieze, Elske, Demyttenaere, Koen, Bruffaerts, Ronny, Hermans, Dirk, Pizzagalli, Diego A, Sienaert, Pascal, Hompes, Titia, de Boer, Peter, Schmidt, Mark, Claes, Stephan

“…Abstract Background Major depressive disorder (MDD) is a heterogeneous disease. More homogeneous psycho(patho)logical dimensions would facilitate MDD research…”
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Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial by Recourt, Kasper, van der Aart, Jasper, Jacobs, Gabriel, de Kam, Marieke, Drevets, Wayne, van Nueten, Luc, Kanhai, Kawita, Siebenga, Pieter, Zuiker, Rob, Ravenstijn, Paulien, Timmers, Maarten, van Gerven, Joop, de Boer, Peter

“…Background: This is the first report of the pharmacodynamic (PD) effects of the selective, potent and brain-penetrant P2X7 receptor (P2X7R) antagonist…”
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Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants by Timmers, Maarten, Ravenstijn, Paulien, Xi, Liwen, Triana-Baltzer, Gallen, Furey, Maura, Van Hemelryck, Sandy, Biewenga, Jeike, Ceusters, Marc, Bhattacharya, Anindya, van den Boer, Maarten, van Nueten, Luc, de Boer, Peter

“…Background: Central nervous system-derived interleukin-1β plays a role in mood disorders. P2X7 receptor activation by adenosine-triphosphate leads to the…”
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DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation by Derijck, Alwin, van der Heijden, Godfried, Giele, Maud, Philippens, Marielle, de Boer, Peter

“…In the human, the contribution of the sexes to the genetic load is dissimilar. Especially for point mutations, expanded simple tandem repeats and structural…”
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Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network by Mueller, Felix, Musso, Francesco, London, Markus, de Boer, Peter, Zacharias, Norman, Winterer, Georg

“…Subanesthetic dosages of the NMDAR antagonist, S-Ketamine, can cause changes in behavior in healthy subjects, which are similar to the state acute psychosis…”
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A randomized Phase 2 study to evaluate the orexin-2 receptor antagonist seltorexant in individuals with insomnia without psychiatric comorbidity by De Boer, Peter, Drevets, Wayne C, Rofael, Hany, van der Ark, Peter, Kent, Justine M, Kezic, Iva, Parapatics, Silvia, Dorffner, Georg, van Gerven, Joop, Beneš, Heike, Keicher, Christian, Jahn, Holger, Seiden, David J, Luthringer, Remy

“…Background: Seltorexant is a potent and selective antagonist of the orexin-2 receptor that is being developed for the treatment of insomnia and major…”
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Deep learning‐based reconstruction of in vivo pelvis conductivity with a 3D patch‐based convolutional neural network trained on simulated MR data by Gavazzi, Soraya, den Berg, Cornelis A. T., Savenije, Mark H. F., Kok, H. Petra, Boer, Peter, Stalpers, Lukas J. A., Lagendijk, Jan J. W., Crezee, Hans, Lier, Astrid L. H. M. W.

“…Purpose To demonstrate that mapping pelvis conductivity at 3T with deep learning (DL) is feasible. Methods 210 dielectric pelvic models were generated based on…”
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Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in Meiosis by Soper, Sarah F.C., van der Heijden, Godfried W., Hardiman, Tara C., Goodheart, Mary, Martin, Sandra L., de Boer, Peter, Bortvin, Alex

“…Tight control of transposon activity is essential for the integrity of the germline. Recently, a germ-cell-specific organelle, nuage, was proposed to play a…”
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Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder by Recourt, Kasper, de Boer, Peter, van der Ark, Peter, Benes, Heike, van Gerven, Joop M. A., Ceusters, Marc, van Nueten, Luc, Drevets, Wayne C., Bhatacharya, Anindya, Browning, Michael, Jacobs, Gabriel E.

“…JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446…”
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Changes in protein composition of meiotic nodules during mammalian meiosis by Plug, A W, Peters, A H, Keegan, K S, Hoekstra, M F, de Boer, P, Ashley, T

“…Homologous chromosome synapsis and meiotic recombination are facilitated by several meiosis-specific structures: the synaptonemal complex (SC), and two types…”
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The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia by Brooks, Sander, Jacobs, Gabriël E, de Boer, Peter, Kent, Justine M, Van Nueten, Luc, van Amerongen, Guido, Zuiker, Rob, Kezic, Iva, Luthringer, Remy, van der Ark, Peter, van Gerven, Joop MA, Drevets, Wayne

“…Background: Insomnia is common in patients with major depressive disorder. Although antidepressants improve mood, insomnia often persists as a result of…”
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Immune and Neuroendocrine Trait and State Markers in Psychotic Illness: Decreased Kynurenines Marking Psychotic Exacerbations by De Picker, Livia, Fransen, Erik, Coppens, Violette, Timmers, Maarten, de Boer, Peter, Oberacher, Herbert, Fuchs, Dietmar, Verkerk, Robert, Sabbe, Bernard, Morrens, Manuel

“…Different patterns of immune system upregulation are present in the acute vs. post-treatment states of psychotic illness. We explored the existence of state…”
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Markers of Inflammation and Monoamine Metabolism Indicate Accelerated Aging in Bipolar Disorder by van den Ameele, Seline, Fuchs, Dietmar, Coppens, Violette, de Boer, Peter, Timmers, Maarten, Sabbe, Bernard, Morrens, Manuel

“…A mild pro-inflammatory status accompanies bipolar disorder (BD). Inflammation can cause a shift in monoamine metabolism, thereby activating more cytotoxic…”
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Impact on bird fauna of a non-native oyster expanding into blue mussel beds in the Dutch Wadden Sea by Waser, Andreas M., Deuzeman, Symen, Kangeri, Arno K. wa, van Winden, Erik, Postma, Jelle, de Boer, Peter, van der Meer, Jaap, Ens, Bruno J.

“…Intertidal mussel beds are important for intertidal ecosystems, because they feature a high taxonomic diversity and abundance of benthic organisms and are…”
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Digging deeper in the differential effects of inflammatory and psychosocial stressors in remitted depression: Effects on cognitive functioning by Niemegeers, Peter, de Boer, Peter, Schuermans, Jeroen, Dumont, Glenn J.H., Coppens, Violette, Spittaels, Kurt, Claes, Stephan, Sabbe, Bernard G.C., Morrens, Manuel

“…•Inflammatory stress decreases information processing speed and verbal memory in remitted MDD.•Inflammatory stress increases a negative attentional bias in…”
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Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects by van der Ark, Peter D, Golor, Georg, van Nueten, Luc, Nandy, Partha, de Boer, Peter

“…Background: Pharmacokinetics, pharmacodynamics and general safety and tolerability of JNJ-42847922, a selective orexin-2 receptor antagonist, were assessed in…”
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Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder by Bonaventure, Pascal, Dugovic, Christine, Kramer, Michelle, De Boer, Peter, Singh, Jaskaran, Wilson, Sue, Bertelsen, Kirk, Di, Jianing, Shelton, Jonathan, Aluisio, Leah, Dvorak, Lisa, Fraser, Ian, Lord, Brian, Nepomuceno, Diane, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Chai, Wenying, Dvorak, Curt, Sands, Steve, Carruthers, Nicholas, Lovenberg, Timothy W

“…In rodents 5-hydroxytryptamine type 7 (5-HT(7)) receptor blockade has been shown to be effective in models of depression and to increase the latency to rapid…”
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