Search Results - "de Boer, Marco"

Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats by Rip, Jaap, Chen, Linda, Hartman, Robin, van den Heuvel, Angelique, Reijerkerk, Arie, van Kregten, Joan, van der Boom, Burt, Appeldoorn, Chantal, de Boer, Marco, Maussang, David, de Lange, Elizabeth C. M., Gaillard, Pieter J.

“…Abstract Partly due to poor blood-brain barrier drug penetration the treatment options for many brain diseases are limited. To safely enhance drug delivery to…”
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Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae by Boer, M. de, Nielsen, P.S, Bebelman, J.P, Heerikhuizen, H. van, Andersen, H.A, Planta, R.J

“…Expression of the BAP3 gene of Saccharomyces cerevisiae, encoding a branched chain amino acid permease, is induced in response to the availability of several…”
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Simple, fast and efficient iTOP-mediated delivery of CRISPR/Cas9 RNP in difficult-to-transduce human cells including primary T cells by Kholosy, Waleed M., Visscher, Marieke, Ogink, Kim, Buttstedt, Helen, Griffin, Kelli, Beier, Axel, Gerlach, Jan Patrick, Molenaar, Jan J., Geijsen, Niels, de Boer, Marco, Chatsisvili, Anna

“…•The optimized iTOP technology® is a simple, fast and efficient intracellular delivery method for CRISPR/Cas9 RNPs.•Primary human cells can be edited…”
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Regulation of expression of the amino acid transporter gene BAP3 in Saccharomyces cerevisiae by Boer, M. de, Bebelman, J.P, Goncalves, P.M, Maat, J, Heerikhuizen, H. van, Planta, R.J

“…The BAP3 gene of Saccharomyces cerevisiae encodes a protein with a high similarity to the BAP2 gene product, a high‐affinity permease for branched‐chain amino…”
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Glutathione conjugation dose-dependently increases brain-specific liposomal drug delivery in vitro and in vivo by Maussang, David, Rip, Jaap, van Kregten, Joan, van den Heuvel, Angelique, van der Pol, Susanne, van der Boom, Burt, Reijerkerk, Arie, Chen, Linda, de Boer, Marco, Gaillard, Pieter, de Vries, Helga

“…[Display omitted] The blood–brain barrier (BBB) represents a major obstacle for the delivery and development of drugs curing brain pathologies. However, this…”
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Systemic treatment with glutathione PEGylated liposomal methylprednisolone (2B3-201) improves therapeutic efficacy in a model of ocular inflammation by Reijerkerk, Arie, Appeldoorn, Chantal C M, Rip, Jaap, de Boer, Marco, Gaillard, Pieter J

“…Ocular inflammation is associated with the loss of visual acuity and subsequent blindness. Since their development, glucocorticoids have been the mainstay of…”
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CROSSBETA STABLE Aβ OLIGOMERS: DISEASE-RELEVANT DRUG TARGETS AND VERSATILE REFERENCE STANDARDS IN BIOMARKER ASSAYS IN AD by Apetri, Mihaela, Tepper, Armand W.J.W., Hoogveld, Emily, Vis, Joost D.J., de Boer, Marco, Scheefhals, Guus A.P.H.

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Glutathione pegylated liposomal methylprednisolone administration after the early phase of status epilepticus did not modify epileptogenesis in the rat by Holtman, Linda, van Vliet, Erwin A, Appeldoorn, Chantal, Gaillard, Pieter J, de Boer, Marco, Dorland, Rick, Wadman, Wytse J, Gorter, Jan A

“…Highlights • Liposome nanotechnology is used to enhance brain delivery of methylprednisolone. • Methylprednisolone did not affect status epilepticus induced…”
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NOVEL AB OLIGOMER–SPECIFIC ANTIBODIES AND STABILIZED AB OLIGOMERS AS RELIABLE AND DISEASE RELEVANT REFERENCE STANDARDS IN ALZHEIMER’S BIOMARKER ASSAYS by Tepper, Armand W.J.W, van Diggelen, Femke, de Poli, Angela, Scheefhals, Guus A.P.H, Vis, Joost D.J, Hoogveld, Emily, Schut, Ivar C, Anderegg, Birgit, de Boer, Marco

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P2‐161: Novel AB Oligomer–Specific Antibodies and Stabilized AB Oligomers as Reliable and Disease Relevant Reference Standards in Alzheimer’s Biomarker Assays by Tepper, Armand W.J.W., Diggelen, Femke, Poli, Angela, Scheefhals, Guus A.P.H., Vis, Joost D.J., Hoogveld, Emily, Schut, Ivar C., Anderegg, Birgit, Boer, Marco

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CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis by Evans, Matthew C, Gaillard, Pieter J, de Boer, Marco, Appeldoorn, Chantal, Dorland, Rick, Sibson, Nicola R, Turner, Martin R, Anthony, Daniel C, Stolp, Helen B

“…Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis…”
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Upcycling drugs for brain-related diseases: a sustainable future for targeted drug delivery by de Boer, Marco, Visser, Corine C, Gaillard, Pieter J

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