Search Results - "de Boer, Anita M."
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Aged versus fresh autologous platelet transfusion in a two‐hit healthy volunteer model of transfusion‐related acute lung injury
Published in Transfusion (Philadelphia, Pa.) (01-12-2022)“…Background Transfusion‐related acute lung injury (TRALI) is a severe complication of blood transfusion that is thought of as a two‐hit event: first the…”
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Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats
Published in Molecular medicine (Cambridge, Mass.) (22-05-2024)“…Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can augment lung…”
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Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients
Published in Intensive care medicine (01-07-2015)“…Purpose We investigated the prognostic value of plasma soluble urokinase plasminogen activator receptor (suPAR) on day 1 in patients with the acute respiratory…”
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Influence of bacterial and alveolar cell co-culture on microbial VOC production using HS-GC/MS
Published in Frontiers in molecular biosciences (26-04-2023)“…Volatile organic compounds (VOCs) found in exhaled breath continue to garner interest as an alternative diagnostic tool in pulmonary infections yet, their…”
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Kinetics of plasma biomarkers of inflammation and lung injury in surgical patients with or without postoperative pulmonary complications
Published in European journal of anaesthesiology (01-04-2017)“…BACKGROUNDPostoperative pulmonary complications (PPCs) are common after major abdominal surgery. The kinetics of plasma biomarkers could improve identification…”
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Transfusion of female blood in a rat model is associated with red blood cells entrapment in organs
Published in PloS one (22-11-2023)“…Transfusion of red blood cells (RBCs) has been associated with adverse outcomes. Mechanisms may be related to donor sex and biological age of RBC. This study…”
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Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia
Published in Critical care (London, England) (30-07-2014)“…Induced hypothermia is increasingly applied as a therapeutic intervention in ICUs. One of the underlying mechanisms of the beneficial effects of hypothermia is…”
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The impact of biological age of red blood cell on in vitro endothelial activation markers
Published in Frontiers in physiology (08-03-2023)“…Blood donor characteristics influence red blood cell transfusion outcomes. As donor sex affects the distribution of young to old RBCs in the circulation, we…”
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Transfusion of 35‐day‐stored red blood cells does not alter lipopolysaccharide tolerance during human endotoxemia
Published in Transfusion (Philadelphia, Pa.) (01-06-2017)“…BACKGROUND Transfusion‐related immunomodulation (TRIM) encompasses immunosuppressive and proinflammatory effects induced by red blood cell (RBC) transfusion…”
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Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles
Published in International journal of molecular sciences (15-12-2022)“…Endotheliopathy following trauma is associated with poor outcome, but the underlying mechanisms are unknown. This study hypothesized that an increased…”
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Lactated Ringers, albumin and mannitol as priming during cardiopulmonary bypass reduces pulmonary edema in rats compared with hydroxyethyl starch
Published in Intensive care medicine experimental (07-09-2024)“…Background Endothelial disorders with edema formation and microcirculatory perfusion disturbances are common in cardiac surgery with cardiopulmonary bypass…”
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Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort study
Published in Critical care (London, England) (16-11-2011)“…Soluble urokinase-type plasminogen activator receptor (suPAR) has been proposed as a biologic marker of fibrinolysis and inflammation. The aim of this study…”
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Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study
Published in ERJ open research (01-03-2023)“…Changes in exhaled volatile organic compounds (VOCs) can be used to discriminate between respiratory diseases, and increased concentrations of hydrocarbons are…”
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Early increase in anti-inflammatory biomarkers is associated with the development of multiple organ dysfunction syndrome in severely injured trauma patients
Published in Trauma surgery & acute care open (01-10-2019)“…BackgroundAs a result of improvements in the early resuscitation phase of trauma, mortality is largely driven by later mortality due to multiple organ…”
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Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury
Published in PloS one (30-11-2012)“…Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung…”
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Therapeutic Effects of Troglitazone in Experimental Chronic Pancreatitis in Mice
Published in The American journal of pathology (01-03-2005)“…Peroxisome proliferator-activated receptor (PPAR)-γ controls growth, differentiation, and inflammation. PPAR-γ agonists exert anti-inflammatory effects in…”
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Serum levels of N-terminal proB-type natriuretic peptide in mechanically ventilated critically ill patients--relation to tidal volume size and development of acute respiratory distress syndrome
Published in BMC pulmonary medicine (09-07-2013)“…Serum levels of N-terminal proB-type natriuretic peptide (NT-proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed…”
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Modulation of angiopoietin-2 and Tie2: Organ specific effects of microvascular leakage and edema in mice
Published in Microvascular research (01-07-2024)“…Critical illness is associated with organ failure, in which endothelial hyperpermeability and tissue edema play a major role. The endothelial angiopoietin/Tie2…”
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Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans
Published in Critical care medicine (01-06-2016)“…OBJECTIVE:Transfusion-related acute lung injury is the leading cause of transfusion-related mortality. Preclinical studies have shown that aged RBCs can induce…”
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Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis
Published in European journal of anaesthesiology (01-09-2018)“…BACKGROUNDBiological phenotypes have been identified within several heterogeneous pulmonary diseases, with potential therapeutic consequences. OBJECTIVETo…”
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