Search Results - "de Bock, Charles E"

In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia by Omari, Sofia A., Kosasih, Hansen J., Chung, Thomas, de Bock, Charles E.

“…Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important…”
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Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer by Connerty, Patrick, Lock, Richard B, de Bock, Charles E

“…Cellular stress can occur in many forms; oxidative stress caused by reactive oxygen species (ROS), metabolic stress from increased metabolic programs and…”
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miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense by Pajic, Marina, Froio, Danielle, Daly, Sheridan, Doculara, Louise, Millar, Ewan, Graham, Peter H, Drury, Alison, Steinmann, Angela, de Bock, Charles E, Boulghourjian, Alice, Zaratzian, Anaiis, Carroll, Susan, Toohey, Joanne, O'Toole, Sandra A, Harris, Adrian L, Buffa, Francesca M, Gee, Harriet E, Hollway, Georgina E, Molloy, Timothy J

“…Radiotherapy is essential to the treatment of most solid tumors and acquired or innate resistance to this therapeutic modality is a major clinical problem…”
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Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease by Sadeqzadeh, Elham, de Bock, Charles E., Thorne, Rick F.

“…The vertebrate Fat cadherins comprise a small gene family of four members, Fat1–Fat4, all closely related in structure to Drosophila ft and ft2. Over the past…”
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HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort by Page, Elyse C., Heatley, Susan L., Eadie, Laura N., McClure, Barbara J., de Bock, Charles E., Omari, Sofia, Yeung, David T., Hughes, Timothy P., Thomas, Paul Q., White, Deborah L.

“…The genetic basis of the predisposition for Down Syndrome (DS) patients to develop cytokine receptor-like factor 2 rearranged ( CRLF2r ) acute lymphoblastic…”
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Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia by Murray, Heather C., Enjeti, Anoop K., Kahl, Richard G. S., Flanagan, Hayley M., Sillar, Jonathan, Skerrett-Byrne, David A., Al Mazi, Juhura G., Au, Gough G., de Bock, Charles E., Evans, Kathryn, Smith, Nathan D., Anderson, Amanda, Nixon, Brett, Lock, Richard B., Larsen, Martin R., Verrills, Nicole M., Dun, Matthew D.

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Evaluating nuclear translocation of surface receptors: recommendations arising from analysis of CD44 by Thorne, Rick F., Wang, Yan, Zhang, Yan, Jing, Xueli, Zhang, Xu Dong, de Bock, Charles E., Oliveira, Camila S.

“…CD44 is a transmembrane receptor that acts as adhesion protein, fundamentally recognizing hyaluronan, an essential component of the extracellular matrix. It…”
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T-ALL: Home Is where the CXCL12 Is by de Bock, Charles E., Cools, Jan

“…T cell acute lymphoblastic leukemia (T-ALL) is caused by mutations affecting cell survival, proliferation, and differentiation. In addition to requiring these…”
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PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia by Beck, Dominik, Cao, Honghui, Tian, Feng, Huang, Yizhou, Jiang, Miao, Zhao, Han, Tai, Xiaolu, Xu, Wenqian, Kosasih, Hansen J., Kealy, David J., Zhao, Weiye, Taylor, Samuel J., Couttas, Timothy A., Song, Gaoxian, Chacon-Fajardo, Diego, Walia, Yashna, Wang, Meng, Dowle, Adam A., Holding, Andrew N., Bridge, Katherine S., Zhang, Chao, Wang, Jin, Mi, Jian-Qing, Lock, Richard B., de Bock, Charles E., Jing, Duohui

“…The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential…”
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Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia by Connerty, Patrick, Moles, Ernest, de Bock, Charles E., Jayatilleke, Nisitha, Smith, Jenny L., Meshinchi, Soheil, Mayoh, Chelsea, Kavallaris, Maria, Lock, Richard B.

“…Standard of care therapies for children with acute myeloid leukemia (AML) cause potent off-target toxicity to healthy cells, highlighting the need to develop…”
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Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL by Sadras, Teresa, Jalud, Fatimah B., Kosasih, Hansen J., Horne, Christopher R., Brown, Lauren M., El-Kamand, Sam, de Bock, Charles E., McAloney, Lachlan, Ng, Ashley P., Davidson, Nadia M., Ludlow, Louise E. A., Oshlack, Alicia, Cowley, Mark J., Khaw, Seong L., Murphy, James M., Ekert, Paul G.

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Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma by De Coninck, Stien, De Smedt, Renate, Lintermans, Beatrice, Reunes, Lindy, Kosasih, Hansen J, Reekmans, Alexandra, Brown, Lauren M, Van Roy, Nadine, Palhais, Bruno, Roels, Juliette, Van der Linden, Malaika, Van Dorpe, Jo, Ntziachristos, Panagiotis, Van Delft, Frederik W, Mansour, Marc R, Pieters, Tim, Lammens, Tim, De Moerloose, Barbara, De Bock, Charles E, Goossens, Steven, Van Vlierberghe, Pieter

“…T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematologic malignancies. Current treatment consists…”
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Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia by Dun, Matthew D., Mannan, Abdul, Rigby, Callum J., Butler, Stephen, Toop, Hamish D., Beck, Dominik, Connerty, Patrick, Sillar, Jonathan, Kahl, Richard G. S., Duchatel, Ryan J., Germon, Zacary, Faulkner, Sam, Chi, Mengna, Skerrett-Byrne, David, Murray, Heather C., Flanagan, Hayley, Almazi, Juhura G., Hondermarck, Hubert, Nixon, Brett, De Iuliis, Geoff, Chamberlain, Janis, Alvaro, Frank, de Bock, Charles E., Morris, Jonathan C., Enjeti, Anoop K., Verrills, Nicole M.

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Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia by Van Thillo, Quentin, De Bie, Jolien, Seneviratne, Janith A., Demeyer, Sofie, Omari, Sofia, Balachandran, Anushree, Zhai, Vicki, Tam, Wai L., Sweron, Bram, Geerdens, Ellen, Gielen, Olga, Provost, Sarah, Segers, Heidi, Boeckx, Nancy, Marshall, Glenn M., Cheung, Belamy B., Isobe, Kiyotaka, Kato, Itaru, Takita, Junko, Amos, Timothy G., Deveson, Ira W., McCalmont, Hannah, Lock, Richard B., Oxley, Ethan P., Garwood, Maximilian M., Dickins, Ross A., Uyttebroeck, Anne, Carter, Daniel R., Cools, Jan, de Bock, Charles E.

“…Spi-1 Proto-Oncogene (SPI1) fusion genes are recurrently found in T-cell acute lymphoblastic leukemia (T-ALL) cases but are insufficient to drive…”
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Optimized flow cytometric detection of transient receptor potential vanilloid-1 (TRPV1) in human hematological malignancies by Omari, Sofia A., Geraghty, Dominic P., Khalafallah, Alhossain A., Venkat, Pooja, Shegog, Yvette M., Ragg, Scott J., de Bock, Charles E., Adams, Murray J.

“…The ectopic overexpression of transient receptor potential vanilloid-1 (TRPV1) has been detected in numerous solid cancers, including breast, prostate,…”
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T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development by de Bock, Charles E, Down, Michelle, Baidya, Kinsha, Sweron, Bram, Boyd, Andrew W, Fiers, Mark, Burns, Gordon F, Molloy, Timothy J, Lock, Richard B, Soulier, Jean, Taghon, Tom, Van Vlierberghe, Pieter, Cools, Jan, Holst, Jeff, Thorne, Rick F

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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia by Toscan, Cara E., McCalmont, Hannah, Ashoorzadeh, Amir, Lin, Xiaojing, Fu, Zhe, Doculara, Louise, Kosasih, Hansen J., Cadiz, Roxanne, Zhou, Anthony, Williams, Sarah, Evans, Kathryn, Khalili, Faezeh, Cai, Ruilin, Yeats, Kristy L., Gifford, Andrew J., Pickford, Russell, Mayoh, Chelsea, Xie, Jinhan, Henderson, Michelle J., Trahair, Toby N., Patterson, Adam V., Smaill, Jeff B., de Bock, Charles E., Lock, Richard B.

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that expresses high levels of the enzyme aldo-keto reductase family 1…”
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A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing by Verboom, Karen, Van Loocke, Wouter, Volders, Pieter-Jan, Decaesteker, Bieke, Avila Cobos, Francisco, Bornschein, Simon, de Bock, Charles E, Kalender Atak, Zeynep, Clappier, Emmanuelle, Aerts, Stein, Cools, Jan, Soulier, Jean, Taghon, Tom, Van Vlierberghe, Pieter, Vandesompele, Jo, Speleman, Frank, Durinck, Kaat

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JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia by de Bock, Charles E., Cools, Jan

“…Sequencing data from large cohorts of T-cell acute lymphoblastic leukemia patients identified a significant association between the presence of JAK3 mutations…”
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The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models by Vicente, Carmen, Stirparo, Rocco, Demeyer, Sofie, de Bock, Charles E, Gielen, Olga, Atkins, Mardelle, Yan, Jiekun, Halder, Georg, Hassan, Bassem A, Cools, Jan

“…The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in…”
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