Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: A Systematic Review

Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: A Systematic Review

•Eleven studies investigated the association of inflammation with neurodevelopment.•Preterm newborn inflammation has been associated with cognitive and motor changes.•Preterm newborn inflammation may cause lifelong functional impairment. To provide a systematic review investigating the role of infla...

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Bibliographic Details
Published in:International journal of developmental neuroscience Vol. 65; no. 1; pp. 29 - 37
Main Authors: Magalhães, Rafael C., Pimenta, Letícia P., Barbosa, Izabela G., Moreira, Janaina M., de Barros, João L.V.M., Teixeira, Antônio L., Simões e Silva, Ana C.
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 01-04-2018
Elsevier BV
Subjects:
Acute phase proteins
Adhesion tests
Biomarkers
Chemokines
Child
Child Development
Cognition - physiology
Cognitive ability
Cognitive development
Correlation analysis
Cytokines
Cytokines - metabolism
Databases, Bibliographic
Delay
Growth factors
Humans
Infant, Premature - physiology
Infants
Inflammation
Insulin-like growth factor-binding protein 1
Interleukin 6
Interleukin 8
Molecular chains
Monocyte chemoattractant protein 1
Motor development
Neonates
Nerve Growth Factors - metabolism
Neurotrophic factors
Plasma levels
Populations
Premature birth
Preterm
Proteins
Psychomotor Performance - physiology
RANTES
Risk analysis
Risk factors
Tumor necrosis factor
Vascular endothelial growth factor
Inflammation
Cognitive development
Cytokines
Motor development
Neurotrophic factors
Preterm
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Summary:•Eleven studies investigated the association of inflammation with neurodevelopment.•Preterm newborn inflammation has been associated with cognitive and motor changes.•Preterm newborn inflammation may cause lifelong functional impairment. To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.
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ISSN:0736-5748
1873-474X
DOI:10.1016/j.ijdevneu.2017.10.006