Longitudinal bone microarchitectural changes are best detected using image registration

Longitudinal bone microarchitectural changes are best detected using image registration

Summary Longitudinal studies of bone using high-resolution medical imaging may result in non-physiological measurements of longitudinal changes. In this study, we determined that three-dimensional image processing techniques best capture realistic longitudinal changes in bone density and should ther...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international Vol. 31; no. 10; pp. 1995 - 2005
Main Authors: Kemp, T.D., de Bakker, C.M.J., Gabel, L., Hanley, D.A., Billington, E.O., Burt, L.A., Boyd, S.K.
Format: Journal Article
Language:English
Published: London Springer London 01-10-2020
Springer Nature B.V
Subjects:
Aged
Bone and Bones
Bone Density
Bone imaging
Bone mineral density
Computed tomography
Endocrinology
Female
Humans
Image processing
Longitudinal studies
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Orthopedics
Osteoporosis
Physiology
Radius
Radius - diagnostic imaging
Registration
Rheumatology
Tibia
Tibia - diagnostic imaging
Tomography, X-Ray Computed
Least significant change
HR-pQCT
Longitudinal analysis
Bone density
3D registration
Bone microarchitecture
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Longitudinal studies of bone using high-resolution medical imaging may result in non-physiological measurements of longitudinal changes. In this study, we determined that three-dimensional image processing techniques best capture realistic longitudinal changes in bone density and should therefore be used with high-resolution imaging when studying bone changes over time. Introduction The purpose of this study was to determine which longitudinal analysis technique (no registration (NR), slice-match (SM) registration, or three-dimensional registration (3DR)) produced the most realistic longitudinal changes in a 3-year study of bone density and structure using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods We assessed HR-pQCT scans of the distal radius and tibia for men and women ( N  = 40) aged 55–70 years at baseline and 6, 12, 24, and 36 months. To evaluate which longitudinal analysis technique (NR, SM, or 3DR) best captured physiologically reasonable 3-year changes, we calculated the standard deviation of the absolute rate of change in each bone parameter. The data were compared between longitudinal analysis techniques using repeated measures ANOVA and post hoc analysis. Results As expected, both SM and 3DR better captured physiological longitudinal changes than NR. At the tibia, there were no differences between SM and 3DR; however, at the radius where precision was lower, 3DR produced better results for total bone mineral density. Conclusions At least SM or 3DR should be implemented in longitudinal studies using HR-pQCT. 3DR is preferable, particularly at the radius, to ensure that physiological changes in bone density are observed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-020-05449-2