Search Results - "de Baets, Marc"

Robotic Thymectomy for Thymomas: A Retrospective Follow-up Study in the Netherlands by Marcuse, Florit, Hochstenbag, Monique, De Baets, Marc H.V., Bootsma, Gerben, Maat, Alexander P.W.M., Hoeijmakers, Janneke G.J., Keijzers, Marlies, Abdul Hamid, Myrurgia, De Ruysscher, Dirk, Maessen, Jos G.

“…The Maastricht University Medical Center+ is a Dutch center of expertise appointed by the Netherlands Federation of University Medical Centers for the…”
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Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis by Cufi, Perrine, Dragin, Nadine, Weiss, Julia Miriam, Martinez-Martinez, Pilar, De Baets, Marc H., Roussin, Régine, Fadel, Elie, Berrih-Aknin, Sonia, Le Panse, Rozen

“…Objective Myasthenia gravis (MG) is an autoimmune disease mediated mainly by anti–acetylcholine receptor (AChR) antibodies. The thymus plays a primary role in…”
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Outcomes after robotic thymectomy in nonthymomatous versus thymomatous patients with acetylcholine-receptor-antibody-associated myasthenia gravis by Marcuse, Florit, Hoeijmakers, Janneke G.J., Hochstenbag, Monique, Hamid, Myrurgia Abdul, Keijzers, Marlies, Mané-Damas, Marina, Martinez-Martinez, Pilar, Verschuuren, Jan, Kuks, Jan, Beekman, Roy, van der Kooi, Anneke J., van Doorn, Pieter, van Es, Michael, Maessen, Jos J.G., De Baets, Marc H.V.

“…•Robotic thymectomy is safe and feasible in patients with myasthenia gravis.•The majority of the patients (82.4%) improved in MG manifestations after robotic…”
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IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients by Koneczny, Inga, Stevens, Jo A.A, De Rosa, Anna, Huda, Saif, Huijbers, Maartje G, Saxena, Abhishek, Maestri, Michelangelo, Lazaridis, Konstantinos, Zisimopoulou, Paraskevi, Tzartos, Socrates, Verschuuren, Jan, van der Maarel, Silvère M, van Damme, Philip, De Baets, Marc H, Molenaar, Peter C, Vincent, Angela, Ricciardi, Roberta, Martinez-Martinez, Pilar, Losen, Mario

“…Abstract Autoimmunity mediated by IgG4 subclass autoantibodies is an expanding field of research. Due to their structural characteristics a key feature of IgG4…”
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Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice by KLOOSTER, Rinse, PLOMP, Jaap J, MARTINEZ-MARTINEZ, Pilar, DE BAETS, Marc H, DER MAAREL, Silvère M. Van, VERSCHUUREN, Jan J, HUIJBERS, Maartje G, NIKS, Erik H, STRAASHEIJM, Kirsten R, DETMERS, Frank J, HERMANS, Pim W, SLEIJPEN, Kevin, VERRIPS, Aad, LOSEN, Mario

“…Myasthenia gravis is a paralytic disorder with autoantibodies against acetylcholine receptors at the neuromuscular junction. A proportion of patients instead…”
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Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels by BOSMA, Madeleen, HESSELINK, Matthijs K. C, KERSTEN, Sander, SCHRAUWEN, Patrick, SPARKS, Lauren M, TIMMERS, Silvie, FERRAZ, Maria Joao, MATTIJSSEN, Frits, BEURDEN, Denis Van, SCHAART, Gert, DE BAETS, Marc H, VERHEYEN, Fons K

“…Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and…”
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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange by van der Neut Kolfschoten, Marijn, Schuurman, Janine, Losen, Mario, Bleeker, Wim K., Martínez-Martínez, Pilar, Vermeulen, Ellen, Bleker, Tamara H. den, Wiegman, Luus, Vink, Tom, Aarden, Lucien A., De Baets, Marc H., van de Winkel, Jan G. J., Aalberse, Rob C., Parren, Paul W. H. I.

“…Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe…”
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Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor by Vrolix, Kathleen, Fraussen, Judith, Losen, Mario, Stevens, Jo, Lazaridis, Konstantinos, Molenaar, Peter C, Somers, Veerle, Bracho, Maria Alma, Le Panse, Rozen, Stinissen, Piet, Berrih-Aknin, Sonia, Maessen, Jos G, Van Garsse, Leen, Buurman, Wim A, Tzartos, Socrates J, De Baets, Marc H, Martinez-Martinez, Pilar

“…Abstract Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR–MG) is considered as a prototypic autoimmune disease. The thymus is…”
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Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle by Timmers, Silvie, de Vogel-van den Bosch, Johan, Hesselink, Matthijs K C, van Beurden, Denis, Schaart, Gert, Ferraz, Maria Joao, Losen, Mario, Martinez-Martinez, Pilar, De Baets, Marc H, Aerts, Johannes M F G, Schrauwen, Patrick

“…The involvement of muscle triacylglycerol (TAG) storage in the onset of insulin resistance is questioned and the attention has shifted towards inhibition of…”
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Globe Subluxation following Long-Term High-Dose Steroid Treatment for Myasthenia Gravis by Dam, Jasmien, Marcuse, Florit, De Baets, Marc, Cassiman, Catherine

“…This case report describes the unusual presentation of a globe subluxation following long-term high-dose oral steroid treatment for myasthenia gravis (MG). The…”
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Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity by Luo, Jie, Taylor, Palmer, Losen, Mario, de Baets, Marc H, Shelton, G. Diane, Lindstrom, Jon

“…The main immunogenic region (MIR) is a conformation-dependent region at the extracellular apex of alpha1 subunits of muscle nicotinic acetylcholine receptor…”
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Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder by Hoffmann, Carolin, Stevens, Jo, Zong, Shenghua, van Kruining, Daan, Saxena, Abhishek, Küçükali, Cem İsmail, Tüzün, Erdem, Yalçınkaya, Nazlı, De Hert, Marc, González-Vioque, Emiliano, Arango, Celso, Lindstrom, Jon, De Baets, Marc H, Rutten, Bart P F, van Os, Jim, Molenaar, Peter, Losen, Mario, Martinez-Martinez, Pilar

“…The α7 acetylcholine receptor (AChR) has been linked with the onset of psychotic symptoms and we hypothesized therefore that it might also be an autoimmune…”
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Detection of human polyomavirus 7 in human thymic epithelial tumors by Rennspiess, Dorit, Pujari, Sreedhar, Keijzers, Marlies, Abdul-Hamid, Myrurgia A, Hochstenbag, Monique, Dingemans, Anne-Marie, Kurz, Anna Kordelia, Speel, Ernst-Jan, Haugg, Anke, Pastrana, Diana V, Buck, Christopher B, De Baets, Marc H, Zur Hausen, Axel

“…Although the molecular genetics possibly underlying the pathogenesis of human thymoma have been extensively studied, its etiology remains poorly understood…”
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In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery by De Vry, Jochen, Martínez-Martínez, Pilar, Losen, Mario, Temel, Yasin, Steckler, Thomas, Steinbusch, Harry W M, De Baets, Marc H, Prickaerts, Jos

“…Electroporation is a widely used technique for enhancing the efficiency of DNA delivery into cells. Application of electric pulses after local injection of DNA…”
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Myasthenia gravis with muscle specific kinase antibodies mimicking amyotrophic lateral sclerosis by Huijbers, Maartje G., MSc, Niks, Erik H., MD PhD, Klooster, Rinse, PhD, de Visser, Marianne, MD PhD, Kuks, Jan B., MD PhD, Veldink, Jan H., MD PhD, Klarenbeek, Pim, MD, de Baets, Marc H., MD PhD, Van Damme, Philip, MD PhD, van der Maarel, Silvère M., PhD, van den Berg, Leonard, MD PhD, Verschuuren, Jan J., MD PhD

“…Highlights • MuSK myasthenia gravis may mimic bulbar ALS. • MuSK MG is not present in bulbar ALS that fulfills revised El Escorial criteria. • Lack of disease…”
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Complement activation by ceramide transporter proteins by Bode, Gerard H, Losen, Mario, Buurman, Wim A, Veerhuis, Robert, Molenaar, Peter C, Steinbusch, Harry W M, De Baets, Marc H, Daha, Mohamed R, Martinez-Martinez, Pilar

“…C1q is the initiator of the classical complement pathway and, as such, is essential for efficient opsonization and clearance of pathogens, altered…”
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Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys by Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, Molenaar, Peter C., Martinez-Martinez, Pilar, van der Esch, Eline, Schuurman, Janine, de Baets, Marc H., Parren, Paul W. H. I.

“…Autoantibodies against ion channels are the cause of numerous neurologic autoimmune disorders. Frequently, such pathogenic autoantibodies have a restricted…”
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Antibody effector mechanisms in myasthenia gravis-Pathogenesis at the neuromuscular junction by Gomez, Alejandro M., Van Den Broeck, Joost, Vrolix, Kathleen, Janssen, Sofie P., Lemmens, Marijke A. M., Van Der Esch, Eline, Duimel, Hans, Frederik, Peter, Molenaar, Peter C., Martínez-Martínez, Pilar, De Baets, Marc H., Losen, Mario

“…Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that are either directed to the muscle nicotinic acetylcholine receptor (AChR) or to…”
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Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors by Chteinberg, Emil, Klufah, Faisal, Rennspiess, Dorit, Mannheims, Mick F., Abdul‐Hamid, Myrurgia A., Losen, Mario, Keijzers, Marlies, De Baets, Marc H., Kurz, Anna Kordelia, zur Hausen, Axel

“…Background The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using…”
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Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain[S] by Vlassaks, Evi, Mencarelli, Chiara, Nikiforou, Maria, Strackx, Eveline, Ferraz, Maria J., Aerts, Johannes M., De Baets, Marc H., Martinez-Martinez, Pilar, Gavilanes, Antonio W.D.

“…Fetal asphyctic preconditioning, induced by a brief episode of experimental hypoxia-ischemia, offers neuroprotection to a subsequent more severe asphyctic…”
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