Search Results - "de Baaij, Jeroen H.F"
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Magnesium Counteracts Vascular Calcification: Passive Interference or Active Modulation?
Published in Arteriosclerosis, thrombosis, and vascular biology (01-08-2017)“…Over the last decade, an increasing number of studies report a close relationship between serum magnesium concentration and cardiovascular disease risk in the…”
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Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes
Published in Endocrine reviews (01-06-2023)“…Abstract Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in the healthy population. Factors that are involved in this high…”
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3
Mitochondrial Dysfunction in Kidney Tubulopathies
Published in Annual review of physiology (12-02-2024)“…Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the…”
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Magnesium and calciprotein particles in vascular calcification: the good cop and the bad cop
Published in Current opinion in nephrology and hypertension (01-07-2019)“…PURPOSE OF REVIEWVascular calcification is a major contributor to increased cardiovascular mortality in chronic kidney disease (CKD). Recently, calciprotein…”
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5
CNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemia
Published in PLoS genetics (01-04-2014)“…Intellectual disability and seizures are frequently associated with hypomagnesemia and have an important genetic component. However, to find the genetic origin…”
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Genetics of renovascular hypertension in children
Published in Journal of hypertension (01-10-2020)“…OBJECTIVE:In most cases of renovascular hypertension in children, the cause is unclear. The aim of this study was to investigate genetic variation as a factor…”
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Withdrawn as duplicate: Expanding the phenotypic spectrum of Kenny-Caffey syndrome: a case series and systematic literature review
Published in The journal of clinical endocrinology and metabolism (16-06-2023)“…This article has been withdrawn due to a publisher error that caused it to be duplicated. The definitive version of this article is published under…”
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8
Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)
Published in The Journal of biological chemistry (20-04-2012)“…Recently, mutations in the cyclin M2 (CNNM2) gene were identified to be causative for severe hypomagnesemia. In kidney, CNNM2 is a basolaterally expressed…”
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Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth
Published in The Journal of biological chemistry (13-05-2016)“…The oncogenic phosphatase of regenerating liver 2 (PRL-2) has been shown to regulate intracellular magnesium levels by forming a complex through an extended…”
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10
Identification of SLC41A3 as a novel player in magnesium homeostasis
Published in Scientific reports (28-06-2016)“…Regulation of the body Mg 2+ balance takes place in the distal convoluted tubule (DCT), where transcellular reabsorption determines the final urinary Mg 2+…”
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11
Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients
Published in Canadian journal of physiology and pharmacology (01-06-2020)“…Metformin therapy is associated with lower serum magnesium (Mg ) levels in type 2 diabetes patients. The TRPM6 channel determines the fine-tuning of Mg…”
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Development of a villi-like micropatterned porous membrane for intestinal magnesium and calcium uptake studies
Published in Acta biomaterialia (01-11-2019)“…[Display omitted] Intestinal enterocytes are key players in the absorption of magnesium (Mg2+) and calcium (Ca2+). Understanding the exact molecular mechanisms…”
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Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice
Published in Scientific reports (11-02-2019)“…Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg 2+ ) concentration <0.7 mmol/L). In T2D patients,…”
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14
A de novo KCNA1 Mutation in a Patient with Tetany and Hypomagnesemia
Published in Nephron (2015) (01-01-2018)“…Mutations in the KCNA1 gene encoding the voltage-gated potassium (K+) channel Kv1.1 have been linked to rare neurological syndromes, episodic ataxia type 1…”
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Effect of Dapagliflozin Treatment on the Expression of Renal Sodium Transporters/Channels on High-Fat Diet Diabetic Mice
Published in Nephron (2015) (01-01-2019)“…Inhibition of the Na+/glucose co-transporter 2 is a new therapeutic strategy for diabetes. It is unclear how proximal loss of Na+ (and glucose) affects the…”
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Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia: a case–control study
Published in Pharmacogenetics and genomics (01-03-2017)“…OBJECTIVEProton pump inhibitors (PPIs) are effective drugs for the treatment of gastric acid-related disorders. Serious adverse events are rare for PPIs, but…”
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Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling
Published in Journal of the American Society of Nephrology (01-03-2016)“…The transient receptor potential melastatin type 6 (TRPM6) epithelial Mg(2+) channels participate in transcellular Mg(2+) transport in the kidney and…”
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Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review
Published in American journal of nephrology (01-01-2015)“…Autosomal dominant tubulointerstitial kidney disease subtype HNF1B (ADTKD-HNF1B) is caused by a mutation in hepatocyte nuclear factor 1 homeobox beta (HNF1B)…”
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The genetic spectrum of Gitelman(-like) syndromes
Published in Current opinion in nephrology and hypertension (12-07-2022)Get full text
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Magnesium reabsorption in the kidney
Published in American journal of physiology. Renal physiology (01-03-2023)“…Mg is essential for many cellular and physiological processes, including muscle contraction, neuronal activity, and metabolism. Consequently, the blood Mg…”
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