β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response

Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the s...

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Bibliographic Details
Published in:	Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 12
Main Authors:	Júnior, Luiz C. R., de Oliveira, Alaíde B., Monteiro, Marta C., Dorneles, Gilson P., de A. Pontes, Anna C. A., dos Santos, Sávio M., de Oliveira, Juliana P., Quadros, Lucas B. G., Monteiro, Valter V. S., Navegantes-Lima, Kely C., de B. Oliveira, Ana L., Romão, Pedro R. T.
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 2020 Hindawi Hindawi Limited
Subjects:	Antibiotics Antioxidants Cytokines Experiments Laboratory animals Oxidative stress Pharmacy Sepsis Tumor necrosis factor-TNF St Louis Missouri United States > US
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Summary:	Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. β-Lapachone (β-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of β-Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, β-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, β-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with β-Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the β-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Guodong Zhang
ISSN:	1942-0900 1942-0994
DOI:	10.1155/2020/8820651