Search Results - "de Azevedo, Walter F. Jr"

Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus by Fadel, Valmir, Bettendorff, Pascal, Herrmann, Torsten, de Azevedo Jr, Walter F., Oliveira, Eduardo B., Yamane, Tetsuo, Wüthrich, Kurt

“…Crotamine is one of four major components of the venom of the South American rattlesnake Crotalus durissus terrificus. Similar to its counterparts in the…”
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Purification, Characterization, and Preliminary X-Ray Diffraction Analysis of a Lactose-Specific Lectin from Cymbosema roseum Seeds by Rocha, Bruno A. M, Moreno, Frederico B. M. B, Delatorre, Plínio, Souza, Emmanuel P, Marinho, Emmanuel S, Benevides, Raquel G, Rustiguel, Joane Kathelen Rodrigues, Souza, Luis A. G, Nagano, Celso S, Debray, Henri, Sampaio, Alexandre H, de Azevedo, Walter F. Jr, Cavada, Benildo S

“…The unique carbohydrate-binding property of lectins makes them invaluable tools in biomedical research. Here, we report the purification, partial primary…”
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SKPDB: a structural database of shikimate pathway enzymes by Arcuri, Helen A, Zafalon, Geraldo Fd, Marucci, Evandro A, Bonalumi, Carlos E, da Silveira, Nelson Jf, Machado, José M, de Azevedo, Jr, Walter F, Palma, Mário S

“…The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design. The…”
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Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis by Arcuri, Helen A., Borges, Júlio C., Fonseca, Isabel O., Pereira, José H., Neto, João Ruggiero, Basso, Luiz A., Santos, Diógenes S., de Azevedo Jr, Walter F.

“…Tuberculosis (TB) remains the leading cause of mortality due to a single bacterial pathogen, Mycobacterium tuberculosis. The reemergence of TB as a potential…”
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Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products by Sánchez-Quitian, Zilpa A., Timmers, Luís F.S.M., Caceres, Rafael A., Rehm, Jacqueline G., Thompson, Claudia E., Basso, Luiz A., de Azevedo, Walter F., Santos, Diógenes S.

“…► The present study provided structural insight into the product binding patterns for CDA. ► The residues Asn45, Glu47, Ala57, Cys89, and Cys92 are pivotal to…”
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Purification, partial characterization and preliminary X-ray diffraction analysis of a mannose-specific lectin from Cymbosema roseum seeds by Cavada, Benildo S., Marinho, Emmanuel S., Souza, Emmanuel P., Benevides, Raquel G., Delatorre, Plínio, Souza, Luis A. G., Nascimento, Kyria S., Sampaio, Alexandre H., Moreno, Frederico B. M. B., Rustiguel, Joane K. R., Canduri, Fernanda, De Azevedo Jr, Walter F., Debray, Henri

“…A lectin from Cymbosema roseum seeds (CRL) was purified, characterized and crystallized. The best crystals grew in a month and were obtained by the…”
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cDNA cloning and 1.75 Å crystal structure determination of PPL2, an endochitinase and N‐acetylglucosamine‐binding hemagglutinin from Parkia platycephala seeds by Cavada, Benildo S., Moreno, Frederico B. B., da Rocha, Bruno A. M., de Azevedo, Walter F., Castellón, Rolando E. R., Goersch, Georg V., Nagano, Celso S., de Souza, Emmanuel P., Nascimento, Kyria S., Radis‐Baptista, Gandhi, Delatorre, Plínio, Leroy, Yves, Toyama, Marcos H., Pinto, Vicente P. T., Sampaio, Alexandre H., Barettino, Domingo, Debray, Henri, Calvete, Juan J., Sanz, Libia

“…Parkia platycephala lectin 2 was purified from Parkia platycephala (Leguminosae, Mimosoideae) seeds by affinity chromatography and RP‐HPLC. Equilibrium…”
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Crystallization and preliminary X-ray diffraction analysis of a new chitin-binding protein from Parkia platycephala seeds by Cavada, Benildo S., Castellón, Rolando E. R., Vasconcelos, Georg G., Rocha, Bruno A. M., Debray, Henri, Bezerra, Gustavo A., Delatorre, Plínio, Nagano, Celso S., Toyama, Marcos, Pinto, Vicente P. T., Moreno, Frederico B. M. B., Canduri, Fernanda, De Azevedo Jr, Walter F.

“…A chitin‐binding protein named PPL‐2 was purified from Parkia platycephala seeds and crystallized. Crystals belong to the orthorhombic space group P212121,…”
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Preface “Molecular Structure and Mechanisms of Action of Antioxidants” by Ildiz, Gulce Ogruc, de Azevedo, Walter F., Fausto, Rui

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Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia gladiata seeds by Moreno, Frederico B. M. B., Delatorre, Plínio, Freitas, Beatriz T., Rocha, Bruno A. M., Souza, Emmanuel P., Facó, Felipe, Canduri, Fernanda, Cardoso, André L. H., Freire, Valder N., Lima Filho, José L., Sampaio, Alexandre H., Calvete, Juan J., De Azevedo Jr, Walter F., Cavada, Benildo S.

“…The seed lectin from Canavalia gladiata was purified and crystallized. Orthorhombic crystals belonging to space group C2221 grew within three weeks at 293 K…”
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Structural studies of PNP from Toxoplasma gondii by Vivan, Ana Luiza, Caceres, Rafael A, Basso, Luiz Augusto, Santos, Diogenes Santiago

“…Toxoplasmosis is a chronic infection that affects approximately 30% of the human population and is caused by Toxoplasma gondii. Determination of the three…”
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Identification of new potential Mycobacterium tuberculosis shikimate kinase inhibitors through molecular docking simulations by Vianna, Carolina Pasa, de Azevedo, Walter F.

“…Tuberculosis (TB) is the major cause of human mortality from a curable infectious disease, attacking mainly in developing countries. Among targets identified…”
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Mutational analysis of the GAP-related domain of the neurofibromatosis type 1 gene in Brazilian NF1 patients by Trovó, Alessandra B., Goloni-Bertollo, Eny M., Mancini, Ulises M., Rahal, Paula, Azevedo Jr, Walter F. de, Tajara, Eloiza H.

“…Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder caused by mutations in the NF1 gene. In the present study, a total of 55 unrelated NF1…”
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4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors:  SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects by Kryštof, Vladimír, Cankař, Petr, Fryšová, Iveta, Slouka, Jan, Kontopidis, George, Džubák, Petr, Hajdúch, Marián, Srovnal, Josef, de Azevedo, Walter F, Orság, Martin, Paprskářová, Martina, Rolčík, Jakub, Látr, Aleš, Fischer, Peter M, Strnad, Miroslav

“…In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of ATP antagonists…”
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Antimalarial Activity of Physalins B, D, F, and G by Sá, Matheus S, de Menezes, Maria N, Krettli, Antoniana U, Ribeiro, Ivone M, Tomassini, Therezinha C. B, Ribeiro dos Santos, Ricardo, de Azevedo, Walter F, Soares, Milena B. P

“…The antimalarial activities of physalins B, D, F, and G (1–4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity…”
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Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis by Ducati, Rodrigo G., Basso, Luiz A., Santos, Diógenes S., de Azevedo, Walter F.

“…We describe here the structure of purine nucleoside phosphorylase from Mycobacterium tuberculosis (MtPNP) in complex with sulfate and its natural substrate,…”
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Structural basis for both pro- and anti-inflammatory response induced by mannose-specific legume lectin from Cymbosema roseum by Rocha, Bruno A.M., Delatorre, Plinio, Oliveira, Taianá M., Benevides, Raquel G., Pires, Alana F., Sousa, Albertina A.S., Souza, Luis A.G., Assreuy, Ana Maria S., Debray, Henri, de Azevedo, Walter F., Sampaio, Alexandre H., Cavada, Benildo S.

“…Legume lectins, despite high sequence homology, express diverse biological activities that vary in potency and efficacy. In studies reported here, the…”
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Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis by Oliveira, Jaim S., Pereira, José H., Canduri, Fernanda, Rodrigues, Nathália C., de Souza, Osmar N., de Azevedo, Walter F., Basso, Luiz A., Santos, Diógenes S.

“…An understanding of isoniazid (INH) drug resistance mechanism in Mycobacterium tuberculosis should provide significant insight for the development of newer…”
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Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir by Caceres, Rafael A., Timmers, Luís F.S.M., Ducati, Rodrigo G., da Silva, Diego O.N., Basso, Luiz A., de Azevedo, Walter F., Santos, Diógenes S.

“…Consumption has been a scourge of mankind since ancient times. This illness has charged a high price to human lives. Many efforts have been made to defeat…”
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Protein kinases as targets for antiparasitic chemotherapy drugs by Canduri, Fernanda, Perez, Patrícia Cardoso, Caceres, Rafael A, de Azevedo, Jr, Walter F

“…Parasitic protozoa infecting humans have a great impact on public health, especially in the developing countries. In many instances, the parasites have…”
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