Search Results - "de Azevedo, Inácio Junqueira"
-
1
Phylogenetically diverse diets favor more complex venoms in North American pitvipers
Published in Proceedings of the National Academy of Sciences - PNAS (27-04-2021)“…The role of natural selection in the evolution of trait complexity can be characterized by testing hypothesized links between complex forms and their functions…”
Get full text
Journal Article -
2
Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome
Published in Proceedings of the National Academy of Sciences - PNAS (18-05-2021)“…Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to become part of the toxin arsenal is a significant evolutionary question…”
Get full text
Journal Article -
3
Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom
Published in Molecular biology and evolution (01-03-2015)“…Attempts to reconstruct the evolutionary history of snake toxins in the context of their co-option to the venom gland rarely account for nonvenom snake genes…”
Get full text
Journal Article -
4
The Venom Composition of the Snake Tribe Philodryadini: 'Omic' Techniques Reveal Intergeneric Variability among South American Racers
Published in Toxins (27-06-2023)“…Snakes of the Philodryadini tribe are included in the Dipsadidae family, which is a diverse group of rear-fanged snakes widespread in different ecological…”
Get full text
Journal Article -
5
A transcriptomic view of the proteome variability of newborn and adult Bothrops jararaca snake venoms
Published in PLoS neglected tropical diseases (01-03-2012)“…Snake bite is a neglected public health problem in communities in rural areas of several countries. Bothrops jararaca causes many snake bites in Brazil and…”
Get full text
Journal Article -
6
Proteomic and Glycoproteomic Profilings Reveal That Post-translational Modifications of Toxins Contribute to Venom Phenotype in Snakes
Published in Journal of proteome research (05-08-2016)“…Snake venoms are biological weapon systems composed of secreted proteins and peptides that are used for immobilizing or killing prey. Although…”
Get full text
Journal Article -
7
Integrating high-throughput analysis to create an atlas of replication origins in Trypanosoma cruzi in the context of genome structure and variability
Published in mBio (10-04-2024)“…is the etiologic agent of the most prevalent human parasitic disease in Latin America, Chagas disease. Its genome is rich in multigenic families that code for…”
Get full text
Journal Article -
8
Systems analysis of subjects acutely infected with the Chikungunya virus
Published in PLoS pathogens (01-06-2019)“…The largest ever recorded epidemic of the Chikungunya virus (CHIKV) broke out in 2004 and affected four continents. Acute symptomatic infections are typically…”
Get full text
Journal Article -
9
Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey
Published in BMC genomics (01-08-2012)“…The scorpion Tityus stigmurus is widely distributed in Northeastern Brazil and known to cause severe human envenoming, inducing pain, hyposthesia, edema,…”
Get full text
Journal Article -
10
Multiomics Profiling of Toxins in the Venom of the Amazonian Spider Acanthoscurria juruenicola
Published in Journal of proteome research (04-11-2022)“…Acanthoscurria juruenicola is an Amazonian spider described for the first time almost a century ago. However, little is known about their venom composition…”
Get full text
Journal Article -
11
Venom Composition of Neglected Bothropoid Snakes from the Amazon Rainforest: Ecological and Toxinological Implications
Published in Toxins (01-02-2024)“…Snake venoms have evolved in several families of Caenophidae, and their toxins have been assumed to be biochemical weapons with a role as a trophic adaptation…”
Get full text
Journal Article -
12
Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom
Published in Toxicon (Oxford) (01-12-2012)“…The aim of this study was the isolation of the LAAO from Lachesis muta venom (LmLAAO) and its biochemical, functional and structural characterization. Two…”
Get full text
Journal Article -
13
Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
Published in Scientific reports (21-01-2021)“…The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa . The chronic…”
Get full text
Journal Article -
14
Molecular mechanisms underlying intraspecific variation in snake venom
Published in Journal of proteomics (15-06-2018)“…Elucidating the molecular mechanisms underlying snake venom variability provides important clues for understanding how the biological functions of this…”
Get full text
Journal Article -
15
An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches
Published in PloS one (01-08-2018)“…Phoneutria nigriventer is one of the largest existing true spiders and one of the few considered medically relevant. Its venom contains several neurotoxic…”
Get full text
Journal Article -
16
Venomics Profiling of Thamnodynastes strigatus Unveils Matrix Metalloproteinases and Other Novel Proteins Recruited to the Toxin Arsenal of Rear-Fanged Snakes
Published in Journal of proteome research (03-02-2012)“…Rear-fanged and aglyphous snakes are usually considered not dangerous to humans because of their limited capacity of injecting venom. Therefore, only a few…”
Get full text
Journal Article -
17
Structural and biological characterization of Nattectin, a new C-type lectin from the venomous fish Thalassophryne nattereri
Published in Biochimie (01-06-2011)“…Lectins are glycan-binding receptors that recognize glycan epitopes on foreign pathogens and in the host systems. They can be involved in functions that…”
Get full text
Journal Article -
18
The transcriptome recipe for the venom cocktail of Tityus bahiensis scorpion
Published in Toxicon (Oxford) (01-03-2015)“…Scorpion venom is a mixture of peptides, including antimicrobial, bradykinin-potentiating and anionic peptides and small to medium proteins, such as ion…”
Get full text
Journal Article -
19
Bothrops jararaca venom gland transcriptome: Analysis of the gene expression pattern
Published in Toxicon (Oxford) (15-09-2006)“…Bothrops jararaca is a pit viper responsible for the majority of snake envenoming accidents in Brazil. As an attempt to describe the transcriptional activity…”
Get full text
Journal Article -
20
Differences in PLA2 Constitution Distinguish the Venom of Two Endemic Brazilian Mountain Lanceheads, Bothrops cotiara and Bothrops fonsecai
Published in Toxins (25-03-2022)“…Interspecific differences in snake venom compositions can result from distinct regulatory mechanisms acting in each species. However, comparative analyses…”
Get full text
Journal Article