Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients

This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy pr...

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Bibliographic Details
Published in:	International journal of environmental research and public health Vol. 15; no. 6; p. 1153
Main Authors:	Damascena, Lecidamia Cristina Leite, de Lucena, Nyellisonn Nando Nóbrega, Ribeiro, Isabella Lima Arrais, de Araujo, Tarciana Liberal Pereira, de Castro, Ricardo Dias, Bonan, Paulo Rogério Ferreti, Lima Neto, Eufrásio de Andrade, de Araújo Filho, Luiz Medeiros, Valença, Ana Maria Gondim
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-06-2018 MDPI
Subjects:	Adolescent Amputation Antineoplastic Combined Chemotherapy Protocols - adverse effects Bone cancer Bone marrow Bone Marrow Transplantation Cancer Cancer therapies Chemotherapy Child Child, Preschool Correlation analysis Female Hospitals Humans Infant Longitudinal Studies Male Males Medical prognosis Metastases Mucositis Mucous membrane Natural products Neoplasms - drug therapy Patients Pediatrics Regression analysis Remission Researchers Retrospective Studies Severity of Illness Index Solid tumors Stomatitis - chemically induced Stomatitis - physiopathology Survival Teenagers Young Adult Brazil Rio de Janeiro Brazil mucositis cancer child
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Summary:	This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the criteria, and the data were collected from the patients' records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race ("pardo") (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis ( -value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Rua: Inácio Ramos de Andrade, 398, apt. 301, Ed. Filipéia, Jardim Cidade Universitária/CEP: 58052-210, João Pessoa (PB), Brazil.
ISSN:	1660-4601 1661-7827 1660-4601
DOI:	10.3390/ijerph15061153