Clostridioides difficile infection in dogs with chronic-recurring diarrhea responsive to dietary changes

Five dogs with chronic-recurring diarrhea were positive for Clostridioides difficile infection (CDI), but were unresponsive to treatment with metronidazole. One of these animals was subjected to a colonoscopy, which revealed eosinophilic infiltration of the colon. All five animals completely recover...

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Bibliographic Details
Published in:	Anaerobe Vol. 51; pp. 50 - 53
Main Authors:	Silva, Rodrigo Otávio Silveira, de Oliveira Júnior, Carlos Augusto, Blanc, Dominique S., Pereira, Silvia Trindade, de Araujo, Mário Cesar Rennó, Vasconcelos, Artur, Lobato, Francisco Carlos Faria
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2018
Subjects:	Animals Anti-Infective Agents - administration & dosage C. difficile infection Chronic Disease - epidemiology Chronic Disease - therapy Chronic Disease - veterinary Clostridium difficile - isolation & purification Clostridium Infections - epidemiology Clostridium Infections - microbiology Clostridium Infections - therapy Clostridium Infections - veterinary Colon - pathology Colonoscopy Diarrhea - epidemiology Diarrhea - microbiology Diarrhea - therapy Diarrhea - veterinary Diet Therapy Dog Diseases - epidemiology Dog Diseases - microbiology Dog Diseases - therapy Dogs Inflammatory bowel disease Intestinal dysbiosis Metronidazole - administration & dosage Treatment Outcome Inflammatory bowel disease Intestinal dysbiosis C. difficile infection
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Summary:	Five dogs with chronic-recurring diarrhea were positive for Clostridioides difficile infection (CDI), but were unresponsive to treatment with metronidazole. One of these animals was subjected to a colonoscopy, which revealed eosinophilic infiltration of the colon. All five animals completely recovered after dietary changes. The present work suggests that CDI might occur in dogs with other intestinal alterations. In addition, this report suggests that dysbiosis should be considered in animals that have chronic-recurring diarrhea and test positive for C. difficile. •C. difficile infection (CDI) in dogs are still largely unknown.•Five dogs with chronic-recurring diarrhea were positive for CDI.•All animals completely recovered after dietary changes.•Dysbiosis should be considered in dogs with chronic-recurring diarrhea and CDI.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1075-9964 1095-8274
DOI:	10.1016/j.anaerobe.2018.03.011