Search Results - "de Araujo, D"

Helix Nucleation by the Smallest Known α-Helix in Water by Hoang, Huy N., Driver, Russell W., Beyer, Renée L., Hill, Timothy A., D. de Araujo, Aline, Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E., Fairlie, David P.

“…Cyclic pentapeptides (e.g. Ac‐(cyclo‐1,5)‐[KAXAD]‐NH2; X=Ala, 1; Arg, 2) in water adopt one α‐helical turn defined by three hydrogen bonds. NMR structure…”
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Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl‑1 Proteins by D. de Araujo, Aline, Lim, Junxian, Wu, Kai-Chen, Xiang, Yibin, Good, Andrew C, Skerlj, Renato, Fairlie, David P

“…A 26-residue peptide BimBH3 binds indiscriminately to multiple oncogenic Bcl2 proteins that regulate apoptosis of cancer cells. Specific inhibition of the…”
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Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications by Gonçalves, L. C., Seabra, A. B., Pelegrino, M. T., de Araujo, D. R., Bernardes, J. S., Haddad, P. S.

“…The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe 3 O 4 NPs),…”
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Hyaluronic acid in Pluronic F-127/F-108 hydrogels for postoperative pain in arthroplasties: Influence on physico-chemical properties and structural requirements for sustained drug-release by Nascimento, M.H.M., Franco, M.K.K.D., Yokaichyia, F., de Paula, E., Lombello, C.B., de Araujo, D.R.

“…In this study, we reported the hyaluronic acid (HA) on supramolecular structure of Pluronic F-127 (PLF-127) and/or Pluronic F-108 (PLF-127) hydrogels, as well…”
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The lupus patient traveller: a guide to the rheumatologist by Oliveira, D S, Hillal, J P D, Cordova, D D P, de Araujo, D B

“…With an increasing number of international journeys occurring daily, there is also an increase in the need for appropriate medical advice for patients who will…”
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Structural and functional consequences of the STAT5BN642H driver mutation by de Araujo, Elvin D., Erdogan, Fettah, Neubauer, Heidi A., Meneksedag-Erol, Deniz, Manaswiyoungkul, Pimyupa, Eram, Mohammad S., Seo, Hyuk-Soo, Qadree, Abdul K., Israelian, Johan, Orlova, Anna, Suske, Tobias, Pham, Ha T. T., Boersma, Auke, Tangermann, Simone, Kenner, Lukas, Rülicke, Thomas, Dong, Aiping, Ravichandran, Manimekalai, Brown, Peter J., Audette, Gerald F., Rauscher, Sarah, Dhe-Paganon, Sirano, Moriggl, Richard, Gunning, Patrick T.

“…Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5B N642H , a frequently-occurring oncogenic driver…”
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Direct Targeting Options for STAT3 and STAT5 in Cancer by Orlova, Anna, Wagner, Christina, de Araujo, Elvin D, Bajusz, Dávid, Neubauer, Heidi A, Herling, Marco, Gunning, Patrick T, Keserű, György M, Moriggl, Richard

“…Signal transducer and activator of transcription (STAT)3 and STAT5 are important transcription factors that are able to mediate or even drive cancer…”
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Effects of 15d‐PGJ2‐loaded poly(D,L‐lactide‐co‐glycolide) nanocapsules on inflammation by Alves, CF, de Melo, NFS, Fraceto, LF, de Araújo, DR, Napimoga, MH

“…BACKGROUND AND PURPOSE The PPAR‐γ agonist 15d‐PGJ2 is a potent anti‐inflammatory agent but only at high doses. To improve the efficiency of 15d‐PGJ2, we used…”
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Diagnosis and treatment of interstitial lung disease related to systemic autoimmune myopathies: a narrative review by De Souza, F H C, De Araújo, D B, Hoff, L S, Baldi, B G, Faria, M S M S, Da Rocha Junior, L F, Da Silva, L R S, Behrens Pinto, G L, Bezerra, M C, Miossi, R, Cordeiro, R A, Shinjo, S K

“…Systemic autoimmune myopathies (SAMs) are rare diseases that lead to muscle inflammation and may be associated with a variety of systemic manifestations…”
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Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities by Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

“…Pharmacologic blockade of the activation of signal transducer and activator of transcription 3 (STAT3) in tyrosine kinase inhibitor (TKI)‐resistant chronic…”
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Soil microbial C:N:P ratio across physiognomies of Brazilian Cerrado Soil microbial biomass across a gradient of preserved native Cerrado by ROCHA, SANDRA M.B., ANTUNES, JADSON E.L., ARAUJO, FABIO F. DE, MENDES, LUCAS W., SOUSA, RICARDO S. DE, ARAUJO, ADEMIR S. F. DE

“…Different physiognomies across the Cerrado could influence the microbial C:N:P ratio in the soil since these physiognomies present different abundance and…”
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Comparative α-Helicity of Cyclic Pentapeptides in Water by de Araujo, Aline D., Hoang, Huy N., Kok, W. Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A., Driver, Russell W., Price, David A., Liras, Spiros, Fairlie, David P.

“…Helix‐constrained polypeptides have attracted great interest for modulating protein–protein interactions (PPI). It is not known which are the most effective…”
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Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering by Muttenthaler, Markus, Andersson, Asa, de Araujo, Aline D, Dekan, Zoltan, Lewis, Richard J, Alewood, Paul F

“…Disulfide bond engineering is an important approach to improve the metabolic half-life of cysteine-containing peptides. Eleven analogues of oxytocin were…”
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SH2db, an information system for the SH2 domain by Bajusz, Dávid, Pándy-Szekeres, Gáspár, Takács, Ágnes, de Araujo, Elvin D, Keserű, György M

“…Abstract SH2 domains are key mediators of phosphotyrosine-based signalling, and therapeutic targets for diverse, mostly oncological, disease indications. They…”
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Encapsulated nitrate replacing soybean meal in diets with and without monensin on in vitro ruminal fermentation by Natel, Andressa S, Abdalla, Adibe Luiz, Araujo, Rafael C DE, Paim, Tiago P, Abdalla Filho, Adibe Luiz, Louvandini, Patrícia, Lima, Melki K, Piza, Paola

“…This study assessed the association between encapsulated nitrate product (ENP) and monensin (MON) to mitigate enteric methane (CH4) in vitro and possible…”
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Ovarian reserve in women with primary antiphospholipid syndrome by Yamakami, LYS, Serafini, PC, de Araujo, DB, Bonfá, E, Leon, EP, Baracat, EC, Silva, CA

“…Objective The objective of this paper is to evaluate ovarian reserve in primary antiphospholipid syndrome (PAPS) women and the association between ovarian…”
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Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma by Sorger, Helena, Dey, Saptaswa, Vieyra‐Garcia, Pablo Augusto, Pölöske, Daniel, Teufelberger, Andrea R, de Araujo, Elvin D, Sedighi, Abootaleb, Graf, Ricarda, Spiegl, Benjamin, Lazzeri, Isaac, Braun, Till, Garces de los Fayos Alonso, Ines, Schlederer, Michaela, Timelthaler, Gerald, Kodajova, Petra, Pirker, Christine, Surbek, Marta, Machtinger, Michael, Graier, Thomas, Perchthaler, Isabella, Pan, Yi, Fink‐Puches, Regina, Cerroni, Lorenzo, Ober, Jennifer, Otte, Moritz, Albrecht, Jana D, Tin, Gary, Abdeldayem, Ayah, Manaswiyoungkul, Pimyupa, Olaoye, Olasunkanmi O, Metzelder, Martin L, Orlova, Anna, Berger, Walter, Wobser, Marion, Nicolay, Jan P, André, Fiona, Nguyen, Van Anh, Neubauer, Heidi A, Fleck, Roman, Merkel, Olaf, Herling, Marco, Heitzer, Ellen, Gunning, Patrick T, Kenner, Lukas, Moriggl, Richard, Wolf, Peter

“…Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐homing mature T‐cells causing severe symptoms and high mortality through…”
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The Importance of Wild Canids in the Epidemiology of Rabies in Northeast Brazil: A Retrospective Study by Cordeiro, R. de A., Duarte, N. F. H., Rolim, B. N., Soares Júnior, F. A., Franco, I. C. F., Ferrer, L. L., Almeida, C. P., Duarte, B. H., de Araújo, D. B., Rocha, M. F. G., Brilhante, R. S. N., Favoretto, S. R., Sidrim, J. J. C.

“…Summary Rabies is an endemic disease in Brazil, where it is considered a serious public health problem. Although the number of human and dog‐transmitted cases…”
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Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins by Araujo, Aline D., Nguyen, Huy T., Fairlie, David P.

“…The conventional S‐alkylation of cysteine relies upon using activated electrophiles. Here we demonstrate high‐yielding and selective S‐alkylation and…”
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Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples by López‐García, Patricia, Araujo, Aline D., Bergues‐Pupo, Ana E., Tunn, Isabell, Fairlie, David P., Blank, Kerstin G.

“…Coiled coils (CCs) are powerful supramolecular building blocks for biomimetic materials, increasingly used for their mechanical properties. Here, we introduce…”
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