Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) o...

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Bibliographic Details
Published in:	Tumor biology Vol. 35; no. 5; pp. 4983 - 4986
Main Authors:	de Araújo, Rubistenia Miranda Soares, de Melo, Cynthia Farias Vieira, Neto, Fidelis Manes, da Silva, Juarez Nóbrega, Soares, Leonardo Ferreira, de Arruda Cardoso Smith, Marilia, Sousa, Edilson Carvalho, Burbano, Rommel Mario Rodríguez, de Medeiros, Arnaldo Correia, Lima, Eleonidas Moura
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-05-2014 Springer Nature B.V
Subjects:	Biomedical and Life Sciences Biomedicine Brazil Cancer Cancer Research Gastrointestinal diseases Genes Genetic Predisposition to Disease Glutathione S-Transferase pi - genetics Glutathione Transferase - genetics Humans Interferon gamma Receptor Patients Polymorphism Polymorphism, Single Nucleotide Receptors, Interferon - genetics Research Article Stomach Neoplasms - etiology Stomach Neoplasms - genetics Brazil SNPs Gastric cancer
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Summary:	Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1 , GSTT1 , and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher’s exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed ( χ 2 = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1010-4283 1423-0380
DOI:	10.1007/s13277-014-1656-z