Coronavirus disease-related in-hospital mortality: a cohort study in a private healthcare network in Brazil

COVID-19-related in-hospital mortality has been reported at 30.7–47.3% in Brazil, however studies assessing exclusively private hospitals are lacking. This is important because of significant differences existing between the Brazilian private and public healthcare systems. We aimed to determine the...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 6371
Main Authors:	de Oliveira Lima, Helidea, da Silva, Leopoldo Muniz, de Campos Vieira Abib, Arthur, Tavares, Leandro Reis, Santos, Daniel Wagner de Castro Lima, de Araújo, Ana Claudia Lopes Fernandes, Moreira, Laise Pereira, Silveira, Saullo Queiroz, de Melo Silva Torres, Vanessa, Simões, Deborah, Arellano, Ramiro, Ho, Anthony M.-H., Mizubuti, Glenio B.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16-04-2022 Nature Publishing Group Nature Portfolio
Subjects:	692/699/1785 692/700 Brazil - epidemiology Cohort analysis Cohort Studies Coronaviruses COVID-19 COVID-19 - epidemiology Delivery of Health Care Health care Hospital Mortality Hospitalization Humanities and Social Sciences Humans Hypertension Intensive Care Units Mechanical ventilation Middle Aged Mortality multidisciplinary Respiration, Artificial - adverse effects Retrospective Studies Risk Factors SARS-CoV-2 Science Science (multidisciplinary) Brazil
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Summary:	COVID-19-related in-hospital mortality has been reported at 30.7–47.3% in Brazil, however studies assessing exclusively private hospitals are lacking. This is important because of significant differences existing between the Brazilian private and public healthcare systems. We aimed to determine the COVID-19-related in-hospital mortality and associated risk factors in a Brazilian private network from March/2020 to March/2021. Data were extracted from institutional database and analyzed using Cox regression model. Length of hospitalization and death-related factors were modeled based on available independent variables. In total, 38,937 COVID-19 patients were hospitalized of whom 3058 (7.8%) died. Admission to the intensive care unit occurred in 62.5% of cases, and 11.5% and 3.8% required mechanical ventilation (MV) and renal replacement therapy (RRT), respectively. In the adjusted model, age ≥ 61 years-old, comorbidities, and the need for MV and/or RRT were significantly associated with increased mortality (p < 0.05). Obesity and hypertension were associated with the need for MV and RRT (p < 0.05).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-10343-4