Disease burden of congenital Zika virus syndrome in Brazil and its association with socioeconomic data

Zika virus (ZIKV) infection became a global public health concern, causing an epidemic in Latin America from 2015 to 2016, when a sudden increase in cases of microcephaly and other congenital anomalies was observed. In 2016, the Centers for Disease Control and Prevention and the World Health Organiz...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; p. 11882
Main Authors:	de Amorin Vilharba, Bruna Luiza, Yamamura, Mellina, de Azevedo, Micael Viana, Fernandes, Wagner de Souza, Santos-Pinto, Cláudia Du Bocage, de Oliveira, Everton Falcão
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-07-2023 Nature Publishing Group Nature Portfolio
Subjects:	692/699 692/699/255 692/699/255/2514 692/700/478 692/700/478/174 Births Brazil - epidemiology Child Congenital defects Congenital diseases Correlation coefficient Cost of Illness Female Humanities and Social Sciences Humans Microcephaly Microencephaly Mortality multidisciplinary Pregnancy Pregnancy Complications, Infectious Public health Sanitation Science Science (multidisciplinary) Socioeconomic Factors Socioeconomics Spatial analysis Spatial distribution Vector-borne diseases Zika Virus Zika Virus Infection - complications Zika Virus Infection - diagnosis Zika Virus Infection - epidemiology Brazil
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Summary:	Zika virus (ZIKV) infection became a global public health concern, causing an epidemic in Latin America from 2015 to 2016, when a sudden increase in cases of microcephaly and other congenital anomalies was observed. In 2016, the Centers for Disease Control and Prevention and the World Health Organization defined congenital Zika-associated syndrome (CZS) as a set of congenital anomalies seen in children born to mothers with a history of gestational Zika fever, who have microcephaly as the most prevalent clinical sign. In order to describe the magnitude of CZS in Brazil, this study estimated the burden of disease due to CZS in Brazil using the disability-adjusted life years (DALY) indicator and other frequency measures, such as incidence and mortality rate, during the years 2015–2020. The association of these indicators with socioeconomic variables was also evaluated using Spearman's correlation coefficient. Choropleth maps were used to evaluate the spatial distribution of the indicators evaluated and the spatial autocorrelation was verified by the Bivariate Moran Local Index. From 2015 to 2020, 3,591 cases of CZS were confirmed in Brazil, with an incidence of 44.03 cases per 1000 live births, and a specific mortality of 12.35 deaths per 1000 live births. A global loss of 30,027.44 DALYs was estimated from 2015 to 2020. The Northeast region had the highest values for all health indicators assessed. Spatial correlation and autocorrelation analyses showed significant associations between health and socioeconomic indicators, such as per capita income, Gini index, illiteracy rate and basic sanitation. The study allowed us to have access to all reported cases of CZS, showing us the possible situation of the disease in Brazil; therefore, we believe that our results can help in the understanding of future studies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-38553-4