The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia

The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia

Highlights • Respiratory infections represent a globally cause of mortality in childhood. • The inflammatory response appears to play role in recovery from virus respiratory disease. • The virus-positive group showed stronger immunolabeling for ADAM33, ADAM28, IL-4 and IL-13 ( p < 0.0001 for all...

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Bibliographic Details
Published in:Journal of clinical virology Vol. 61; no. 4; pp. 585 - 589
Main Authors: Baurakiades, Emanuele, Costa, Victor Horácio, Raboni, Sonia Mara, de Almeida, Vivian Rafaela Telli, Larsen, Kelly Susana Kunze, Kohler, Juliana Nemetz, Gozzo, Priscilla do Carmo, Klassen, Giseli, Manica, Graciele C.M, de Noronha, Lucia
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-12-2014
Subjects:
Acute Lung Injury - immunology
Acute Lung Injury - pathology
ADAM Proteins - analysis
ADAM28
ADAM33
Allergy and Immunology
Antigens, Viral - analysis
Child, Preschool
Female
Fibrosis - pathology
Humans
IL-13
IL-4
Immunohistochemistry
Infant
Infant, Newborn
Infectious Disease
Interleukin-13 - analysis
Interleukin-4 - analysis
Lung - pathology
Male
Pneumonia
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Virus
Virus
ADAM33
IL-4
ADAM28
Pneumonia
IL-13
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Summary:Highlights • Respiratory infections represent a globally cause of mortality in childhood. • The inflammatory response appears to play role in recovery from virus respiratory disease. • The virus-positive group showed stronger immunolabeling for ADAM33, ADAM28, IL-4 and IL-13 ( p < 0.0001 for all variables). • These proteins might play a role in the inflammatory process in lethal non-pandemic acute viral pneumonias. • These proteins might play a role in alveolar pulmonary fibrosis of virus respiratory infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2014.10.004