Search Results - "de Almeida, Luís Pereira"

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation? by Marcelo, Adriana, Koppenol, Rebekah, de Almeida, Luís Pereira, Matos, Carlos A., Nóbrega, Clévio

“…Stress granules (SGs) are membraneless cell compartments formed in response to different stress stimuli, wherein translation factors, mRNAs, RNA-binding…”
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Role of hypothalamic neurogenesis in feeding regulation by Sousa-Ferreira, Lígia, Almeida, Luís Pereira de, Cavadas, Cláudia

“…Highlights • The hypothalamus is a neurogenic niche in the adult mammalian brain. • Adult hypothalamic neurogenesis contributes to the regulation of…”
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miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production by Cardoso, Ana L., Guedes, Joana R., Pereira de Almeida, Luís, Pedroso de Lima, Maria C.

“…Summary Innate immunity constitutes the first line of defence against both external and endogenous threats in the brain, and microglia cells are considered key…”
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Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway by Cunha-Santos, Janete, Duarte-Neves, Joana, Carmona, Vitor, Guarente, Leonard, Pereira de Almeida, Luís, Cavadas, Cláudia

“…Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a…”
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Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype by Conceição, Mariana, Mendonça, Liliana, Nóbrega, Clévio, Gomes, Célia, Costa, Pedro, Hirai, Hirokazu, Moreira, João Nuno, Lima, Maria C, Manjunath, N, Pereira de Almeida, Luís

“…Abstract Others and we showed that RNA interference holds great promise for the treatment of dominantly inherited neurodegenerative disorders such as…”
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Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice by Mendonça, Liliana S, Nóbrega, Clévio, Hirai, Hirokazu, Kaspar, Brian K, Pereira de Almeida, Luís

“…Machado-Joseph disease is a neurodegenerative disease without effective treatment. Patients with Machado-Joseph disease exhibit significant motor impairments…”
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Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors by Colaço, Mariana, Cruz, Maria T, Almeida, Luís Pereira de, Borges, Olga

“…Nasal vaccines are a promising strategy for enhancing mucosal immune responses and preventing diseases at mucosal sites by stimulating the secretion of…”
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Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice by Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Hirai, Hirokazu, Déglon, Nicole, de Almeida, Luís Pereira

“…Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly-inherited neurodegenerative disorder caused by the…”
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SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway by Leal, Helena, Cardoso, João, Valério, Patrícia, Quatorze, Marta, Carmona, Vítor, Cunha-Santos, Janete, Pereira de Almeida, Luís, Pereira, Cláudia, Cavadas, Cláudia, Gomes, Pedro

“…Nonalcoholic fatty liver disease (NAFLD), a condition strongly associated with obesity and insulin resistance, is characterized by hepatic lipid accumulation…”
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Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado―Joseph disease by NASCIMENTO-FERREIRA, Isabel, NOBREGA, Clévio, VASCONCELOS-FERREIRA, Ana, ONOFRE, Isabel, ALBUQUERQUE, David, AVELEIRA, Célia, HIRAI, Hirokazu, DEGLON, Nicole, DE ALMEIDA, Luis Pereira

“…Machado-Joseph disease or spinocerebellar ataxia type 3, the most common dominantly-inherited spinocerebellar ataxia, results from translation of the…”
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Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease by NASCIMENTO-FERREIRA, Isabel, SANTOS-FERREIRA, Tiago, PEREIRA DE ALMEIDA, Luís, SOUSA-FERREIRA, Lígia, AUREGAN, Gwennaëlle, ONOFRE, Isabel, ALVES, Sandro, DUFOUR, Noëlle, COLOMER GOULD, Veronica F, KOEPPEN, Arnulf, DEGLON, Nicole

“…Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by…”
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Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells by Aveleira, Célia A, Ferreira-Marques, Marisa, Cortes, Luísa, Valero, Jorge, Pereira, Dina, Pereira de Almeida, Luís, Cavadas, Cláudia

“…Abstract Hutchinson-Gilford progeria syndrome (HGPS, or classical progeria) is a rare genetic disorder, characterized by premature aging, and caused by a de…”
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Living Proof of Activity of Extracellular Vesicles in the Central Nervous System by Mahjoum, Shadi, Rufino-Ramos, David, Pereira de Almeida, Luís, Broekman, Marike L. D., Breakefield, Xandra O., van Solinge, Thomas S.

“…The central nervous system (CNS) consists of a heterogeneous population of cells with highly specialized functions. For optimal functioning of the CNS, in…”
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Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia by Gonçalves, Nélio, Simões, Ana T., Prediger, Rui D., Hirai, Hirokazu, Cunha, Rodrigo A., Pereira de Almeida, Luís

“…Objective Machado–Joseph disease (MJD) is a neurodegenerative spinocerebellar ataxia (SCA) associated with an expanded polyglutamine tract within ataxin‐3 for…”
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Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer's Disease by Soares Martins, Tânia, Pelech, Steven, Ferreira, Maria, Pinho, Beatriz, Leandro, Kevin, de Almeida, Luís Pereira, Breitling, Benedict, Hansen, Niels, Esselmann, Hermann, Wiltfang, Jens, da Cruz E Silva, Odete A B, Henriques, Ana Gabriela

“…Phosphorylation plays a key role in Alzheimer's disease (AD) pathogenesis, impacting distinct processes such as amyloid-beta (Aβ) peptide production and tau…”
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Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation by Ferreira-Marques, Marisa, Aveleira, Célia A, Carmo-Silva, Sara, Botelho, Mariana, Pereira de Almeida, Luís, Cavadas, Cláudia

“…Caloric restriction is an anti-aging intervention known to extend lifespan in several experimental models, at least in part, by stimulating autophagy. Caloric…”
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Neuropeptide Y stimulates autophagy in hypothalamic neurons by Aveleira, Célia A., Botelho, Mariana, Carmo-Silva, Sara, Pascoal, Jorge F., Ferreira-Marques, Marisa, Nóbrega, Clévio, Cortes, Luísa, Valero, Jorge, Sousa-Ferreira, Lígia, Álvaro, Ana R., Santana, Magda, Kügler, Sebastian, de Almeida, Luís Pereira, Cavadas, Cláudia

“…Significance Autophagy impairment is a major hallmark of aging, and any intervention that enhances autophagy is of potential interest to delay aging. However,…”
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Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease by Nóbrega, Clévio, Carmo-Silva, Sara, Albuquerque, David, Vasconcelos-Ferreira, Ana, Vijayakumar, Udaya-Geetha, Mendonça, Liliana, Hirai, Hirokazu, de Almeida, Luís Pereira

“…Machado-Joseph disease is a progressive neurodegenerative disorder associated with the polyQ-expanded ataxin-3 (encoded by ATXN3), for which no therapy is…”
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Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease by Alves, Sandro, Nascimento-Ferreira, Isabel, Auregan, Gwennaëlle, Hassig, Raymonde, Dufour, Noëlle, Brouillet, Emmanuel, Pedroso de Lima, Maria C, Hantraye, Philippe, Pereira de Almeida, Luís, Déglon, Nicole

“…Recent studies have demonstrated that RNAi is a promising approach for treating autosomal dominant disorders. However, discrimination between wild-type and…”
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A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia by Martins, Mariana, Oliveira, Ana Rafaela, Martins, Solange, Vieira, José Pedro, Perdigão, Pedro, Fernandes, Ana Rita, de Almeida, Luís Pereira, Palma, Paulo Jorge, Sequeira, Diana Bela, Santos, João Miguel Marques, Duque, Frederico, Oliveira, Guiomar, Cardoso, Ana Luísa, Peça, João, Seabra, Catarina Morais

“…Disruptions in the MBD5 gene have been linked with an array of clinical features such as global developmental delay, intellectual disability, autistic-like…”
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