Search Results - "de Almeida, Luís P"
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Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model
Published in Human molecular genetics (01-12-2014)“…MicroRNAs (miRNAs) have emerged as a class of small, endogenous, regulatory RNAs that exhibit the ability to epigenetically modulate the translation of mRNAs…”
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FTIR Spectroscopy and Blood-Derived Extracellular Vesicles Duo in Alzheimer's Disease
Published in Journal of Alzheimer's disease (02-04-2024)“…Alzheimer's disease (AD) diagnosis is difficult, and new accurate tools based on peripheral biofluids are urgently needed. Extracellular vesicles (EVs) emerged…”
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Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair
Published in Polymers (14-12-2021)“…The present study deals with the development of multifunctional biphasic calcium phosphate (BCP) scaffolds coated with biopolymers-poly(ε-caprolactone) (PCL)…”
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Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins
Published in Communications biology (19-05-2022)“…Cell membrane-based biovesicles (BVs) are important candidate drug delivery vehicles and comprise extracellular vesicles, virus-like particles, and lentiviral…”
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Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
Published in Frontiers in cell and developmental biology (22-09-2020)“…Mitochondrial deregulation has gained increasing support as a pathological mechanism in Huntington’s disease (HD), a genetic-based neurodegenerative disorder…”
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Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites
Published in The Journal of neuroscience (23-03-2011)“…GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The…”
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Bore collapse and wave run-up on a sandy beach
Published in Continental shelf research (15-02-2019)“…Wave run-up on beaches and coastal structures is initiated and driven by collapsing incident bores, this process is often considered to define the seaward…”
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