Search Results - "de Almeida, Larissa Costa"
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Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells
Published in Biochemical pharmacology (01-10-2019)“…[Display omitted] DNA-damaging agents are widely used in cancer therapy; however, their use is limited by dose-related toxicities, as well as the development…”
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2
New Chalcone Ester Derivatives as Potential Cytotoxic Agents
Published in Chemistry & biodiversity (01-11-2024)“…Chalcones are a group of molecules with recognized biological potential against many diseases, including cancer. Thus, studies on this structure and…”
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Novel [6]-gingerol Triazole Derivatives and their Antiproliferative Potential against Tumor Cells
Published in Current topics in medicinal chemistry (01-01-2020)“…Effective cancer treatment is a major public health challenge. The limitations of current therapies and their adverse effects reduce the efficacy of treatment,…”
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4
Education in the health area: initiatives and possibilities envisioned
Published in Acta scientiarum. Health sciences (01-01-2023)“…Interprofessional Education is characterized by a set of collaborative actions, developed by different professionals, from the exchange of knowledge and…”
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Oxidative functionalization of a halimane diterpenoid achieved by fungal transformation
Published in Bioorganic chemistry (01-05-2019)“…[Display omitted] •Biotransformation of substrate (1) by three fungi strains provided seven oxidized derivatives.•Three transformation products are reported…”
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DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
Published in Cancer genetics (01-04-2021)“…•Resistance and secondary carcinogenesis are important in real-life DNA damage-based therapy.•Mutational status for DNA repair-related genes improves choice of…”
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AD80, a multikinase inhibitor, as a potential drug candidate for colorectal cancer therapy
Published in Life sciences (1973) (01-11-2022)“…Colorectal cancer (CRC) is a very heterogeneous disease. One of its hallmarks is the dysregulation of protein kinases, which leads to molecular events related…”
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Lipopeptides from an isolate of Bacillus subtilis complex have inhibitory and antibiofilm effects on Fusarium solani
Published in Applied microbiology and biotechnology (01-10-2023)“…Bacillus subtilis species complex is known as lipopeptide-producer with biotechnological potential for pharmaceutical developments. This study aimed to…”
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Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways
Published in Chemico-biological interactions (01-02-2023)“…DNA-targeting agents have a significant clinical use, although toxicity remains an issue that plays against their widespread application. Understanding the…”
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Organoselenium Has a Potent Fungicidal Effect on Cryptococcus neoformans and Inhibits the Virulence Factors
Published in Antimicrobial agents and chemotherapy (16-03-2023)“…Cryptococcosis therapy is often limited by toxicity problems, antifungal tolerance, and high costs. Studies approaching chalcogen compounds, especially those…”
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Cytotoxic Cyclotides from Anchietea pyrifolia, a South American Plant Species
Published in Journal of natural products (Washington, D.C.) (23-09-2022)“…Cyclotides are mini-proteins with potent bioactivities and outstanding potential for agricultural and pharmaceutical applications. More than 450 different…”
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Structure-activity relationship and mechanistic studies for a series of cinnamyl hydroxamate histone deacetylase inhibitors
Published in Bioorganic & medicinal chemistry (01-04-2021)“…[Display omitted] Histone deacetylases (HDACs) are a family of enzymes that modulate the acetylation status histones and non-histone proteins. Histone…”
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Cuidado interprofissional à criança e ao adolescente: Revisão de escopo
Published in Revista Conexão UEPG (2021)“…The aim of this study was to map the available evidence about interprofessional care for children and adolescents. It is a scoping review developed by the…”
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