Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial

Purpose To analyze the early outcomes of viscosupplementation in patients with severe knee osteoarthritis. Method A randomized, double-blind clinical trial of 143 knees divided into three groups: Group 1 – intra-articular injection of triamcinolone; Group 2 – hylan GF20; and Group 3 – triamcinolone...

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Published in:	International orthopaedics Vol. 41; no. 11; pp. 2273 - 2280
Main Authors:	Campos, André Luiz Siqueira, e Albuquerque, Rodrigo Satamini Pires, da Silva, Edmilson Barbosa, Fayad, Sami Gobbi, Acerbi, Lucas Delunardo, de Almeida, Felipe Nunes, Ooka, Nelson Hiroyuki Myiabe, Franco, José Sergio, Gameiro, Vinícius Schott
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2017
Subjects:	Double-Blind Method Female Follow-Up Studies Glucocorticoids - therapeutic use Humans Hyaluronic Acid - analogs & derivatives Hyaluronic Acid - therapeutic use Injections, Intra-Articular Knee Joint - physiopathology Male Medicine Medicine & Public Health Original Paper Orthopedics Osteoarthritis, Knee - physiopathology Osteoarthritis, Knee - therapy Treatment Outcome Triamcinolone - therapeutic use Viscosupplementation - methods Viscosupplements - therapeutic use Knee Treatment Osteoarthritis Viscosupplementation
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Summary:	Purpose To analyze the early outcomes of viscosupplementation in patients with severe knee osteoarthritis. Method A randomized, double-blind clinical trial of 143 knees divided into three groups: Group 1 – intra-articular injection of triamcinolone; Group 2 – hylan GF20; and Group 3 – triamcinolone + hylan GF20. Outcomes were evaluated using Lysholm and KSS scores before treatment and after one, three and six months. Results Within-group comparisons revealed improvements in Lysholm scores in all groups in the one month evaluation relative to pre-treatment levels ( p < 0.01). This improvement was maintained in the third month after treatment ( p > 0.05). Scores at six months were significantly lower than those observed in the previous follow-up assessments ( p < 0.05), but still higher than pre-treatment levels ( p < 0.05). KSS scores also improved after one month relative to pre-treatment levels ( p < 0.01). This improvement was still present at three and six months after treatment in the corticosteroid group ( p > 0.05). Patients treated with hylan GF20 showed lower scores in the last evaluation relative to month one ( p < 0.05). No significant differences were observed between the treatment groups ( p > 0.05). Conclusions Viscosupplementation increased functional scores in patients with severe osteoarthritis of the knee, especially within three months of injection. However, it was not superior to the use of triamcinolone.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0341-2695 1432-5195
DOI:	10.1007/s00264-017-3625-9