Chemical composition of the essential oil from the leaves of Anaxagorea brevipes (Annonaceae) and evaluation of its bioactivity

The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed by gas chromatography fitted with a flame ionisation detector (GC–FID) and coupled to mass spectrometry (GC–MS). Thirty one components were identified, representing around 75.7% of total oil. The major co...

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Bibliographic Details
Published in:	Natural product research Vol. 30; no. 9; pp. 1088 - 1092
Main Authors:	de Alencar, Danielle Cardoso, Pinheiro, Maria Lúcia Belém, Pereira, José Lamak da Silva, de Carvalho, João Ernesto, Campos, Francinete Ramos, Serain, Alessandra Freitas, Tirico, Ricardo Brunelli, Hernández-Tasco, Alvaro José, Costa, Emmanoel Vilaça, Salvador, Marcos José
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-05-2016
Subjects:	Anaxagorea Anaxagorea brevipes Annonaceae Annonaceae - chemistry Anti-Bacterial Agents - pharmacology anti-infective properties Antifungal Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology antioxidant activity Antioxidants - chemistry Antioxidants - pharmacology bioactivity Cell Line, Tumor chemical composition essential oil essential oils Flame Ionization Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology gas chromatography-mass spectrometry Gram-positive bacteria Gram-Positive Bacteria - drug effects Humans hydrodistillation ionization keratinocytes leaves Microbial Sensitivity Tests minimum inhibitory concentration neoplasms oils Oils, Volatile - analysis Oils, Volatile - pharmacology Plant Leaves - chemistry Sesquiterpenes Sesquiterpenes, Eudesmane yeasts Yeasts - drug effects Annonaceae essential oil Anaxagorea brevipes bioactivity
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Summary:	The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed by gas chromatography fitted with a flame ionisation detector (GC–FID) and coupled to mass spectrometry (GC–MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) and β-bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100 μg/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI = 12.8 μg/mL), NCI-H460 (lung, TGI = 13.0 μg/mL) and PC-3 (prostate, TGI = 9.6 μg/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8 μg/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517 μmol TE/g). This is the first report regarding the chemical composition and bioactivity of A. brevipes essential oil.
Bibliography:	http://dx.doi.org/10.1080/14786419.2015.1101103 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6427 1478-6419 1478-6427
DOI:	10.1080/14786419.2015.1101103