Search Results - "de Abreu Neto, Mario Soares"
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Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
Published in Hematology, Transfusion and Cell Therapy (01-04-2020)“…Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell…”
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A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells
Published in Stem cell reviews (01-02-2018)Get full text
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Approaches for recombinant human factor IX production in serum-free suspension cultures
Published in Biotechnology letters (01-03-2016)“…OBJECTIVE: To establish a serum-free suspension process for production of recombinant human factor IX (rhFIX) based on the human cell line HEK 293T by…”
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Human cell lines: A promising alternative for recombinant FIX production
Published in Protein expression and purification (01-05-2016)“…Factor IX (FIX) is a vitamin K-dependent protein, and it has become a valuable pharmaceutical in the Hemophilia B treatment. We evaluated the potential of…”
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Optimized Production of Lentiviral Vectors for CAR-T Cell
Published in Methods in molecular biology (Clifton, N.J.) (2020)“…Advances in the use of lentiviral vectors for gene therapy applications have created a need for large-scale manufacture of clinical-grade viral vectors for…”
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The F309S mutation increases factor VIII secretion in human cell line
Published in Revista brasileira de hematologia e hemoterapia (01-04-2016)“…The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of…”
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