Search Results - "de Abreu, Francine B."

miRNA analysis in pancreatic cancer: the Dartmouth experience by Abreu, Francine B de, Liu, Xiaoying, Tsongalis, Gregory J

“…Pancreatic cancer is considered one of the most lethal cancers being the fourth leading cause of cancer deaths in adults in the United States because of the…”
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Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature by Olson, Nicholas J., Czum, Julianna M., de Abreu, Francine B., Linos, Konstantinos, Black, Candice C.

“…Pulmonary adenofibroma (PAF) is a rare neoplasm that may be related to solitary fibrous tumor (SFT). A subset of PAFs harbor the NAB2-STAT6 fusion that is…”
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Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non–Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing by Shajani-Yi, Zahra, de Abreu, Francine B., Peterson, Jason D., Tsongalis, Gregory J.

“…The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer. It encodes p53, a DNA-binding transcription factor that regulates multiple…”
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Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations by Tsongalis, Gregory J, Peterson, Jason D, de Abreu, Francine B, Tunkey, Christopher D, Gallagher, Torrey L, Strausbaugh, Linda D, Wells, Wendy A, Amos, Christopher I

“…Somatic mutation analysis is standard of practice for solid tumors in order to identify therapeutic sensitizing and resistance mutations. Our laboratory…”
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A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157 by Hahn, Noah M, Bivalacqua, Trinity J, Ross, Ashley E, Netto, George J, Baras, Alex, Park, Jong Chul, Chapman, Carolyn, Masterson, Timothy A, Koch, Michael O, Bihrle, Richard, Foster, Richard S, Gardner, Thomas A, Cheng, Liang, Jones, David R, McElyea, Kyle, Sandusky, George E, Breen, Timothy, Liu, Ziyue, Albany, Costantine, Moore, Marietta L, Loman, Rhoda L, Reed, Angela, Turner, Scott A, De Abreu, Francine B, Gallagher, Torrey, Tsongalis, Gregory J, Plimack, Elizabeth R, Greenberg, Richard E, Geynisman, Daniel M

“…To assess the clinical and pharmacodynamic activity of dovitinib in a treatment-resistant, molecularly enriched non-muscle-invasive urothelial carcinoma of the…”
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Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth‐Hitchcock Medical Center by Tafe, Laura J., Gorlov, Ivan P., Abreu, Francine B., Lefferts, Joel A., Liu, Xiaoying, Pettus, Jason R., Marotti, Jonathan D., Bloch, Kasia J., Memoli, Vincent A., Suriawinata, Arief A., Dragnev, Konstantin H., Fadul, Camilo E., Schwartz, Gary N., Morgan, Clinton R., Holderness, Britt M., Peterson, Jason D., Tsongalis, Gregory J., Miller, Todd W., Chamberlin, Mary D.

“…Background. Although genetic profiling of tumors is a potentially powerful tool to predict drug sensitivity and resistance, its routine use has been limited…”
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The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma by Biernacka, Anna, Tsongalis, Peter D, Peterson, Jason D, de Abreu, Francine B, Black, Candice C, Gutmann, Edward J, Liu, Xiaoying, Tafe, Laura J, Amos, Christopher I, Tsongalis, Gregory J

“…Abstract KRAS mutant non-small cell lung cancers (NSCLCs) vary in clinical outcome depending on which specific KRAS mutation is present. Shorter progression…”
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Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations by Liu, Xiaoying, Mody, Kabir, de Abreu, Francine B, Pipas, J Marc, Peterson, Jason D, Gallagher, Torrey L, Suriawinata, Arief A, Ripple, Gregory H, Hourdequin, Kathryn C, Smith, Kerrington D, Barth, Jr, Richard J, Colacchio, Thomas A, Tsapakos, Michael J, Zaki, Bassem I, Gardner, Timothy B, Gordon, Stuart R, Amos, Christopher I, Wells, Wendy A, Tsongalis, Gregory J

“…Some epithelial neoplasms of the appendix, including low-grade appendiceal mucinous neoplasm and adenocarcinoma, can result in pseudomyxoma peritonei (PMP)…”
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Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing by Putra, Juan, de Abreu, Francine B., Peterson, Jason D., Pipas, J. Marc, Mody, Kabir, Amos, Christopher I., Tsongalis, Gregory J., Suriawinata, Arief A.

“…Cholangiocarcinoma is a heterogeneous malignant process, which is further classified into intrahepatic cholangiocarcinoma (ICC) and extrahepatic…”
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Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma by Muller, Kristen E., DO, Tafe, Laura J., MD, de Abreu, Francine B., PhD, Peterson, Jason D., MS, Wells, Wendy A., MD, Barth, Richard J., MD, Marotti, Jonathan D., MD

“…Summary We report a unique case of a 59-year-old woman diagnosed with a benign phyllodes tumor (PT), which recurred twice in the same location over a 7-year…”
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Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board by Bernhardt, Erica B., Chamberlin, Mary D., Gorlov, Ivan P., de Abreu, Francine B., Bloch, Katarzyna J., Peterson, Jason D., Tsongalis, Gregory J., Shirai, Keisuke, Dragnev, Konstantin H., Miller, Todd W., Tafe, Laura J.

“…Matching of actionable tumor mutations with targeted therapy increases response rates and prolongs survival in lung cancer patients. Drug development and…”
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Triple-Negative Breast Cancer: Next-Generation Sequencing for Target Identification by Marotti, Jonathan D, de Abreu, Francine B, Wells, Wendy A, Tsongalis, Gregory J

“…Presently, the ability to study disease at the most fundamental molecular level has led to a reclassification of human cancers into numerous subtypes that vary…”
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Non–small cell lung cancers with isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations by Toth, Laura N., de Abreu, Francine B., Tafe, Laura J.

“…Isocitrate dehydrogenases 1 and 2 (IDH1/2) are important metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations are associated with the…”
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The Emerging Role of the Molecular Diagnostics Laboratory in Breast Cancer Personalized Medicine by De Abreu, Francine B, Wells, Wendy A, Tsongalis, Gregory J

“…Breast cancer is a complex disease characterized by many morphological, clinical, and molecular features. For many years, breast cancer has been classified…”
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Rat-bite fever: An uncommon cause of fever and rash in a 9-year-old patient by Miraflor, Allen P., Davallow Ghajar, Ladan, Subramaniam, Sathyaseelan, de Abreu, Francine B., Castanedo-Tardan, Mari Paz, Samie, Faramarz H., Mann, Julianne Anderson, Holmes, Alison Volpe, Tsongalis, Gregory J., Yan, Shaofeng

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Central xanthoma of the jaw in association with Noonan syndrome by Olson, Nicholas J., Addante, Rocco R., de Abreu, Francine B., Memoli, Vincent A.

“…Xanthomas are histiocytic lesions of the skin, soft tissue, and bone and are generally considered to be reactive in nature. When they arise in the bones of the…”
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Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue by de Abreu, Francine B., Gallagher, Torrey L., Liu, Emmeline Z., Tsongalis, Gregory J.

“…O-6-methylguanine-DNA methyltransferase (MGMT) has been associated with resistance to alkylating agent cancer therapy in Glioblastoma (GBM), the most common…”
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Undifferentiated Sarcoma as Intermediate Step in the Progression of Malignant Melanoma to Rhabdomyosarcoma: Histologic, Immunohistochemical, and Molecular Studies of a New Case of Malignant Melanoma With Rhabdomyosarcomatous Differentiation by Tran, Tien Anh N, Linos, Konstantinos, de Abreu, Francine B, Carlson, John Andrew

“…Malignant melanoma (MM) may display highly variable phenotypic diversity, sometimes associated with loss of immunohistochemical melanocytic markers and…”
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Improving Adequacy of Small Biopsy and Fine-Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients With Lung Cancer: A Quality Improvement Study at Dartmouth-Hitchcock Medical Center by Padmanabhan, Vijayalakshmi, Steinmetz, Heather B, Rizzo, Elizabeth J, Erskine, Amber J, Fairbank, Tamara L, de Abreu, Francine B, Tsongalis, Gregory J, Tafe, Laura J

“…- At our medical center, cytopathologists perform rapid on-site evaluation for specimen adequacy of fine-needle aspiration and touch imprint of needle core…”
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Impact of Molecular Sequencing Information as Related to 2008 and 2016 World Health Organization Classification of Acute Myeloid Leukemia and Myelodysplasia by Toth, Laura N, de Abreu, Francine B, Peterson, Jason D, Loo, Eric Y

“…Acute myeloid leukemia (AML) with biallelic mutation of CEBPA underwent revision, and a provisional entity AML with mutated RUNX1 was created.1 All bone marrow…”
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