Search Results - "de Oliveira, Ronaldo Nascimento"
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Comparison of DNA extraction methods for COVID-19 host genetics studies
Published in PloS one (30-10-2023)“…The coronavirus disease 2019 (COVID-19) pandemic has resulted in global shortages in supplies for diagnostic tests, especially in the developing world. Risk…”
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Antiparasitary and antiproliferative activities in vitro of a 1,2,4-oxadiazole derivative on Trypanosoma cruzi
Published in Parasitology research (1987) (01-07-2022)“…Chagas disease (CD) is a neglected disease, prevalent and endemic in Latin America, but also present in Europe and North America. The main treatment used for…”
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Antiviral Activity of Flavonoids from Geopropolis of the Brazilian Jandaira Bee against Zika and Dengue Viruses
Published in Pharmaceutics (01-10-2023)“…Arthropod-borne viruses within the Flaviviridae family such as Zika (ZIKV) and dengue (DENV) are responsible for major outbreaks in tropical countries, and…”
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Anti-Hyperuricemic, Anti-Arthritic, Hemolytic Activity and Therapeutic Safety of Glycoconjugated Triazole-Phthalimides
Published in Biomedicines (01-09-2023)“…Hyperuricemia, the metabolic alteration that leads to gout or gouty arthritis, is increasing worldwide. Glycoconjugated triazole-phthalimides show potent…”
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Correction: Comparison of DNA extraction methods for COVID-19 host genetics studies
Published in PloS one (15-11-2024)“…[This corrects the article DOI: 10.1371/journal.pone.0287551.].[This corrects the article DOI: 10.1371/journal.pone.0287551.]…”
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Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis
Published in European journal of medicinal chemistry (05-08-2021)“…A total of forty-three compounds were synthesized, including thirty-two new ones. Among those compounds, seventeen were selected and tested on human tumor cell…”
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Antiviral activity of ouabain against a Brazilian Zika virus strain
Published in Scientific reports (23-07-2022)“…Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the…”
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Molecular Dynamics of a N-Cyclohexyl-1,2,4-Oxadiazole Derivative as a Reversible Cruzain Inhibitor in Trypanosoma cruzi
Published in Combinatorial chemistry & high throughput screening (01-01-2024)“…Chagas disease kills around 10,000 people yearly, primarily in Latin America, where it is prevalent. Current treatment has limited chronic effectiveness, is…”
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1,2,3- Triazoles: general and key synthetic strategies
Published in ARKIVOC free online journal of organic chemistry (01-01-2020)Get full text
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Anti-Leishmania infantum in vitro effect of n-cyclohexyl-1,2,4-oxadiazole and its ADME/TOX parameters
Published in Journal of parasitic diseases (01-06-2022)“…Leishmaniasis is a disease that represents a serious global health problem with a potentially fatal outcome in some cases. Leishmania spp. is transmitted by…”
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Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives
Published in TheScientificWorld (01-01-2012)“…Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar…”
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Synthesis, Antitumor and Cytotoxic Activity of New Adamantyl O‐Acylamidoximes and 3‐Aryl‐5‐Adamantane‐1,2,4‐Oxadiazole Derivatives
Published in ChemistrySelect (Weinheim) (23-08-2019)“…O‐Acylamidoxime and 1,2,4‐oxadiazole derivatives were synthesized from adamantanecarbonyl chloride 1 and a diversity of arylamidoximes 2 a‐k. First,…”
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Advantages of the use of heterogeneous catalyst for Huisgen cycloaddition reaction: synthesis and application of new metalorganic material capable of regeneration and reuse
Published in Eclética química (29-05-2018)“…This works evaluates the catalytic capacity of metalorganic materials synthesized, based on Cu+ and ambidentade ligand in Huisgen cycloaddition reaction. The…”
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Ivermectin: an award-winning drug with expected antiviral activity against COVID-19
Published in Journal of controlled release (10-01-2021)“…Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe…”
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Synthesis of 1,4-naphthoquinone derivatives using 1,3-dipolar cycloaddition and sonogashira reactions
Published in Orbital : The Electronic Journal of Chemistry (01-01-2010)“…Naphthoquinones are known according to their important bio-activities, such as their antitumoral and topoisomerase inhibition properties. From 2-azido (3) or…”
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Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control
Published in European journal of medicinal chemistry (05-07-2023)“…Malaria can be caused by several Plasmodium species and the development of an effective vaccine is challenging. Currently, the most effective tool to control…”
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Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico ADMET, in vitro activity, docking and molecular dynamic simulations
Published in Bioorganic chemistry (01-12-2020)“…[Display omitted] •The leishmanicidal activity of a triazole-phthalimide derivative (PT4) was evaluated.•PT4 decrease the growth and survival of promastigote…”
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Focused microwave irradiation-assisted synthesis of N-cyclohexyl-1,2,4-oxadiazole derivatives with antitumor activity
Published in Synthetic communications (02-10-2018)“…A facile synthesis of 3,5-disubstituted 1,2,4-oxadiazole derivatives under focused microwave irradiation (FMWI) is reported. Arylamidoximes 1a-i and…”
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Glycerol carbonate in Ferrier reaction: Access to new enantiopure building blocks to develop glycoglycerolipid analogues
Published in Carbohydrate research (21-12-2016)“…Glycerol carbonate and tri-O-acetyl-D-glucal were used for the synthesis of glycero-functionalized carbohydrates. Ferrier reaction between the two partners…”
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