Search Results - "de Araujo, Aline Dantas"

Stapling peptides using cysteine crosslinking by Fairlie, David P, Dantas de Araujo, Aline

“…Stapled peptides are an emerging class of cyclic peptide molecules with enhanced biophysical properties such as conformational and proteolytic stability,…”
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A Novel Long‐Range n to π Interaction Secures the Smallest known α‐Helix in Water by Hoang, Huy N., Wu, Chongyang, Hill, Timothy A., Dantas de Araujo, Aline, Bernhardt, Paul V., Liu, Ligong, Fairlie, David P.

“…The introduction of an amide bond linking side chains of the first and fifth amino acids forms a cyclic pentapeptide that optimally stabilizes the smallest…”
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Cyclization of Peptides by using Selenolanthionine Bridges by de Araujo, Aline Dantas, Mobli, Mehdi, King, Glenn F., Alewood, Paul F.

“…Selenocysteine does the job: Lanthionine bridges are important structural elements in naturally occurring lantibiotics. They can be engineered into peptides to…”
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Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding by de Araujo, Aline Dantas, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J., Alewood, Paul F.

“…Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with…”
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Diels-Alder Ligation of Peptides and Proteins by de Araújo, Aline Dantas, Palomo, Jose M., Cramer, Janina, Seitz, Oliver, Alexandrov, Kirill, Waldmann, Herbert

“…The development of the Diels–Alder cycloaddition as a new method for the site‐specific chemoselective ligation of peptides and proteins under mild conditions…”
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Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc by Madden, Sarah K, de Araujo, Aline Dantas, Gerhardt, Mara, Fairlie, David P, Mason, Jody M

“…c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger…”
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Synthesis of Tripeptide Mimetics Based on Dihydroquinolinone and Benzoxazinone Scaffolds by Dantas de Araujo, Aline, Christensen, Caspar, Buchardt, Jens, Kent, Stephen B. H., Alewood, Paul F.

“…In the image: The design and synthesis of peptidomimetics that maintain the configuration of the triad Asp‐Thr‐Gly found in the catalytic site of the HIV‐1…”
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Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking by Dantas de Araujo, Aline, Perry, Samuel R, Fairlie, David P

“…The use of selenocysteines and various cross-linkers to induce helicity in a bioactive peptide is described. The higher reactivity of selenocysteine, relative…”
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Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor by Dantas de Araujo, Aline, Wu, Chongyang, Wu, Kai-Chen, Reid, Robert C, Durek, Thomas, Lim, Junxian, Fairlie, David P

“…Measuring ligand affinity for a G protein-coupled receptor is often a crucial step in drug discovery. It has been traditionally determined by binding putative…”
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A Novel Long‐Range n to π Interaction Secures the Smallest known α‐Helix in Water by Hoang, Huy N., Wu, Chongyang, Hill, Timothy A., Dantas de Araujo, Aline, Bernhardt, Paul V., Liu, Ligong, Fairlie, David P.

“…The introduction of an amide bond linking side chains of the first and fifth amino acids forms a cyclic pentapeptide that optimally stabilizes the smallest…”
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Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides by Herzig, Volker, de Araujo, Aline Dantas, Greenwood, Kathryn P, Chin, Yanni K-Y, Windley, Monique J, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham M, Alewood, Paul F, King, Glenn F

“…Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about…”
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Review stapling peptides using cysteine crosslinking by Fairlie, David P, Dantas de Araujo, Aline

“…Stapled peptides are an emerging class of cyclic peptide molecules with enhanced biophysical properties such as conformational and proteolytic stability,…”
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Cyclization of Peptides by using Selenolanthionine Bridges by de Araujo, Aline Dantas, Mobli, Mehdi, King, Glenn F., Alewood, Paul F.

“…Lanthionin‐Brücken sind wichtige Strukturelemente in natürlichen Lantibiotika, sie können aber auch in Peptide eingeführt werden, um deren biologische…”
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Direct Visualization of Disulfide Bonds through Diselenide Proxies Using ⁷⁷Se NMR Spectroscopy by Mobli, Mehdi, de Araújo, Aline Dantas, Lambert, Lynette K, Pierens, Gregory K, Windley, Monique J, Nicholson, Graham M, Alewood, Paul F, King, Glenn F

“…Se‐ing is believing: Many proteins are cross‐braced by disulfide bonds that frequently play key roles in protein structure, folding, and function…”
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Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain by de Araujo, Aline Dantas, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthaler, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M., Alewood, Paul F.

“…Poor oral availability and susceptibility to reduction and protease degradation is a major hurdle in peptide drug development. However, drugable receptors in…”
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Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions by Philippe, Grégoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P, Craik, David J., de Araujo, Aline Dantas, Henriques, Sónia Troeira

“…The transcription factor p53 has a tumor suppressor role in leading damaged cells to apoptosis. Its activity is regulated/inhibited in healthy cells by the…”
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Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein–Protein Interaction Site by de Araujo, Aline Dantas, Lim, Junxian, Good, Andrew C, Skerlj, Renato T, Fairlie, David P

“…Protein–protein interactions mediate most physiological and disease processes. Helix-constrained peptides potently mimic or inhibit these interactions by…”
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Do vicinal disulfide bridges mediate functionally important redox transformations in proteins? by de Araujo, Aline Dantas, Herzig, Volker, Windley, Monique J, Dziemborowicz, Sławomir, Mobli, Mehdi, Nicholson, Graham M, Alewood, Paul F, King, Glenn F

“…Vicinal disulfide bridges, in which a disulfide bond is formed between adjacent cysteine residues, constitute an unusual but expanding class of potential…”
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Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding by de Araujo, Aline Dantas, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J., Alewood, Paul F.

“…Eine Lösung für Faltungsprobleme: Selenocystein(Sec)‐Reste wurden genutzt, um die Faltung von Conotoxin MrVIB, einem vormals „unfaltbaren“ Miniprotein mit…”
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Diels-Alder Ligation and Surface Immobilization of Proteins by de Araújo, Aline Dantas, Palomo, Jose M., Cramer, Janina, Köhn, Maja, Schröder, Hendrik, Wacker, Ron, Niemeyer, Christof, Alexandrov, Kirill, Waldmann, Herbert

“…Mild attachment: Proteins can be ligated chemoselectively and immobilized on functionalized glass surfaces by means of Diels–Alder cycloadditions (see scheme)…”
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