Search Results - "de Souza, Helenir Medri"

Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia by de Fatima Silva, Flaviane, Ortiz-Silva, Milene, Galia, Winny Beatriz de Souza, Cassolla, Priscila, da Silva, Francemilson Goulart, Graciano, Maria Fernanda Rodrigues, Carpinelli, Angelo Rafael, de Souza, Helenir Medri

“…Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS…”
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Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice by Vilela, Vanessa Rodrigues, Antunes, Marina Masetto, Godoi, Vilma Aparecida Ferreira, Travassos, Patricia Batista, Souza, Helenir Medri de, Bazotte, Roberto Barbosa

“…We investigated whether oral lactate could prevent seizures and deaths in mice with severe hypoglycemia induced by a high dose of insulin. For this purpose,…”
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Akt activation by insulin treatment attenuates cachexia in Walker‐256 tumor‐bearing rats by Fatima Silva, Flaviane, Morais, Hely, Ortiz Silva, Milene, Silva, Francemilson Goulart, Vianna Croffi, Rafael, Serrano‐Nascimento, Caroline, Rodrigues Graciano, Maria Fernanda, Rafael Carpinelli, Angelo, Barbosa Bazotte, Roberto, Souza, Helenir Medri

“…Cancer‐bearing often exhibits hypoinsulinemia, insulin (INS) resistance and glutamine depletion associated with cachexia. However, INS and glutamine effects on…”
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Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide by Quintilhano, Débora Luiza, Miksza, Daniele Romani, de Souza Galia, Winny Beatriz, Ramalho, Mahira Oliveira Ramalho Costa, Lucena, Camila Ferraz, Valle, Maíra Mello Rezende, Graciano, Maria Fernanda Rodrigues, de Souza, Helenir Medri, Bertolini, Gisele Lopes

“…Lixisenatide, a glucagon-like peptide-1 receptor agonist, is used to stimulate insulin secretion in patients with type 2 diabetes mellitus. However, its effect…”
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Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker‐256 tumor‐bearing rats by Frasson‐Uemura, Isabele Gonçalves, Biazi, Giuliana Regina, Miksza, Daniele Romani, Moreira, Carolina Campos Lima, Cassolla, Priscila, Bertolini, Gisele Lopes, Bazotte, Roberto Barbosa, Souza, Helenir Medri

“…Gluconeogenesis (GN) is increased in patients with cancer cachexia, but is reduced in liver perfusion of Walker‐256 tumor‐bearing cachectic rats (TB rats). The…”
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Gluconeogenesis is reduced from alanine, lactate and pyruvate, but maintained from glycerol, in liver perfusion of rats with early and late sepsis by Souza Galia, Winny Beatriz, Biazi, Giuliana Regina, Frasson‐Uemura, Isabele Gonçalves, Miksza, Daniele Romani, Zaia, Cássia Thaïs Bussamra Vieira, Zaia, Dimas Augusto Morozin, Souza, Helenir Medri, Bertolini, Gisele Lopes

“…Sepsis induces several metabolic abnormalities, including hypoglycaemia in the most advanced stage of the disease, a risk factor for complications and death…”
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Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia by Bassoli, Bruna Kempfer, Cassolla, Priscila, Borba-Murad, Glaucia Regina, Constantin, Jorgete, Salgueiro-Pagadigorria, Clairce Luzia, Bazotte, Roberto Barbosa, da Silva, Rui Sérgio dos Santos Ferreira, de Souza, Helenir Medri

“…The effects of chlorogenic acid (CA) on hepatic glucose output, blood glucose levels and on glucose tolerance were analysed. Hepatic uptake of CA and its…”
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Glucose administration inhibits the hepatic activation of gluconeogenesis promoted by insulin-induced hypoglycemia by Galende, Sharize Betoni, Oliveira Neto, Oswaldo Custódio de, Santos, Leandro Freire dos, Peicher, Márcia Vardanega, Souza, Helenir Medri de, Bazotte, Roberto Barbosa

“…The activation of hepatic gluconeogenesis in male Wistar adult 6 h fasted rats during insulin-induced hypoglycemia (IIH) was previously demonstrated. In this…”
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Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats by de Souza, Camila Oliveira, Kurauti, Mirian Ayumi, de Fatima Silva, Flaviane, de Morais, Hely, Curi, Rui, Hirabara, Sandro Massao, Rosa Neto, José Cesar, de Souza, Helenir Medri

“…Background/Aims: The main purpose of this study was to investigate the effects of celecoxib and ibuprofen, both non-steroidal anti-inflammatory drugs (NSAIDs),…”
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Pivotal role of cAMP in the activation of liver glycogen breakdown in high-fat diet fed mice by Schiavon, Fabiana P.M., Marques, Any de Castro Ruiz, Carrara, Marcia A., de Souza, Helenir Medri, Schamber, Christiano Rodrigues, Curi, Rui, Bazotte, Roberto B.

“…Liver glycogen catabolism was evaluated in male Swiss mice fed a high-fat diet rich in saturated fatty acids (HFD) or normal fat diet (NFD) during one week…”
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Protective Effect of Metformin Against Walker 256 Tumor Growth is Not Dependent on Metabolism Improvement by Franco, Claudinéia Conationi da Silva, Miranda, Rosiane Aparecida, de Oliveira, Júlio Cezar, Barella, Luiz Felipe, Agostinho, Aryane Rodrigues, Prates, Kelly Valério, Malta, Ananda, Trombini, Amanda Bianchi, Torrezan, Rosana, Gravena, Clarice, Tófolo, Laize P., de Sant'Anna, Juliane Rocha, de Castro Prado, Marialba Avezum Alves, de Souza, Camila Oliveira, de Souza, Helenir Medri, Beraldi, Evandro José, Mathias, Paulo Cezar de Freitas

“…Background/Aims: The objective of the current work was to test the effect of metformin on the tumor growth in rats with metabolic syndrome. Methods: We…”
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Contribution of hepatic glycogenolysis and gluconeogenesis in the defense against short-term insulin induced hypoglycemia in rats by Nascimento, Kátia F., Garcia, Rosângela F., Gazola, Vilma A.F.G., de Souza, Helenir Medri, Obici, Simoni, Bazotte, Roberto B.

“…In this study, the contribution of liver glycogenolysis and gluconeogenesis in the defense against short-term insulin induced hypoglycemia (IIH) was…”
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Comparative acute effects of leptin and insulin on gluconeogenesis and ketogenesis in perfused rat liver by Borba-Murad, Glaucia Regina, Mario, Erica Guilhen, Bassoli, Bruna Kempfer, Bazotte, Roberto Barbosa, de Souza, Helenir Medri

“…The acute effects of physiological levels of leptin (10 ng ml−1) and insulin (20 μU ml−1) on hepatic gluconeogenesis and ketogenesis were compared. Leptin or…”
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Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity by Miksza, Daniele Romani, Biazi, Giuliana Regina, Frasson, Isabele Gonçalves, de Souza Galia, Winny Beatriz, Ferraz, Laura Socio, Diaz, Brenda Francisconi, Kurauti, Mirian Ayumi, Marmentini, Carine, Mareze-Costa, Cecília Edna, Peres, Sidney Barnabé, Cassolla, Priscila, Bertolini, Gisele Lopes, Bazotte, Roberto Barbosa, de Souza, Helenir Medri

“…Insulin (INS) resistance and hypoinsulinemia commonly observed in cancer-carrying, can contribute to cachexia. However, the effects of INS and INS sensitizers,…”
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Pioglitazone improves insulin sensitivity and reduces weight loss in Walker-256 tumor-bearing rats by de Fatima Silva, Flaviane, Ortiz-Silva, Milene, de Souza Galia, Winny Beatriz, Cassolla, Priscila, Graciano, Maria Fernanda Rodrigues, Zaia, Cassia Thaïs Bussamra Vieira, Zaia, Dimas, Carpinelli, Ângelo Rafael, da Silva, Francemilson Goulart, de Souza, Helenir Medri

“…The lipogenic effect of pioglitazone (PGZ), an insulin (INS) sensitizer, is well established. However, few studies have evaluated PGZ effects in preventing…”
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Effects of celecoxib and ibuprofen on metabolic disorders induced by Walker-256 tumor in rats by de Souza, Camila Oliveira, Kurauti, Mirian Ayumi, de Fatima Silva, Flaviane, de Morais, Hely, Borba-Murad, Glaucia Regina, de Andrade, Fábio Goulart, de Souza, Helenir Medri

“…The contribution of anti-inflammatory property of celecoxib in the improvement of metabolic disorders in cancer is unknown. The purpose of this study was to…”
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Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats by Moreira, Veridiana Mota, Almeida, Douglas, da Silva Franco, Claudinéia Conationi, Gomes, Rodrigo Mello, Palma‐Rigo, Kesia, Prates, Kelly Valério, Tófolo, Laize Peron, Malta, Ananda, Francisco, Flávio Andrade, Pavanello, Audrei, Previate, Carina, da Silva Silveira, Sandra, Ribeiro, Tatiane Aparecida, Martins, Isabela Peixoto, Moraes, Ana Maria Praxedes, Matiusso, Camila Cristina Ianoni, Saavedra, Lucas Paulo Jacinto, Barros Machado, Katia Gama, Fabbri Corá, Thauany, Gongora, Adriane, Cardozo, Lucas Eduardo, da Silva, Paulo Henrique Olivieri, Venci, Renan, Vieira, Elaine, Oliveira, Júlio Cezar, Miranda, Rosiane Aparecida, Souza, Helenir Medri, Miksza, Daniele, da Costa Lima, Luiz Delmar, Castro‐Prado, Marialba Avezum Alves, Rinaldi, Wilson, Freitas Mathias, Paulo Cezar

“…Key points Cancer growth, cell proliferation and cachexia index can be attenuated by the beneficial programming effect of moderate exercise training,…”
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Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats by de Morais, Hely, de Fatima Silva, Flaviane, da Silva, Francemilson Goulart, Silva, Milene Ortiz, Graciano, Maria Fernanda Rodrigues, Martins, Maria Isabel Lovo, Carpinelli, Ângelo Rafael, Mazucco, Tânia Longo, Bazotte, Roberto Barbosa, de Souza, Helenir Medri

“…Cachexia is the main cause of mortality in advanced cancer patients. We investigated the effects of insulin (INS) and glutamine dipeptide (GDP), isolated or…”
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Aerobic Exercise Training Attenuates Tumor Growth and Reduces Insulin Secretion in Walker 256 Tumor-Bearing Rats by Moreira, Veridiana Mota, da Silva Franco, Claudinéia Conationi, Prates, Kelly Valério, Gomes, Rodrigo Mello, de Moraes, Ana Maria Praxedes, Ribeiro, Tatiane Aparecida, Martins, Isabela Peixoto, Previate, Carina, Pavanello, Audrei, Matiusso, Camila Cristina Ianoni, Almeida, Douglas Lopes, Francisco, Flávio Andrade, Malta, Ananda, Tófolo, Laize Peron, da Silva Silveira, Sandra, Saavedra, Lucas Paulo Jacinto, Machado, Katia, da Silva, Paulo Henrique Olivieri, Fabrício, Gabriel S, Palma-Rigo, Kesia, de Souza, Helenir Medri, de Fátima Silva, Flaviane, Biazi, Giuliana Regina, Pereira, Taís Susane, Vieira, Elaine, Miranda, Rosiane Aparecida, de Oliveira, Júlio Cezar, da Costa Lima, Luiz Delmar, Rinaldi, Wilson, Ravanelli, Maria Ida, de Freitas Mathias, Paulo Cezar

“…Aerobic exercise training can improve insulin sensitivity in many tissues; however, the relationship among exercise, insulin, and cancer cell growth is…”
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Tumor necrosis factor alpha abolished the suppressive effect of insulin on hepatic glucose production and glycogenolysis stimulated by cAMP by da Rocha, Aline Franco, Liboni, Thaís Fernanda, Kurauti, Mirian Ayumi, de Souza, Camila Oliveira, Miksza, Daniele Romani, Moreira, Carolina Campos Lima, Borba-Murad, Glaucia Regina, Bazotte, Roberto Barbosa, de Souza, Helenir Medri

“…Tumor necrosis factor alpha (TNFα) is implicated in the development of insulin resistance in obesity, type 2 diabetes and cancer. However, its ability to…”
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