Search Results - "de Lima Alves, Flavia"

G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells by Zhang, Tuo, Termanis, Ausma, Özkan, Burak, Bao, Xun X., Culley, Jayne, de Lima Alves, Flavia, Rappsilber, Juri, Ramsahoye, Bernard, Stancheva, Irina

“…DNA methylation at imprinting control regions (ICRs) is established in gametes in a sex-specific manner and has to be stably maintained during development and…”
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Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2 by Liang, Shih Chieh, Hartwig, Ben, Perera, Pumi, Mora-García, Santiago, de Leau, Erica, Thornton, Harry, de Lima Alves, Flavia, de Alves, Flavia Lima, Rappsilber, Juri, Rapsilber, Juri, Yang, Suxin, James, Geo Velikkakam, Schneeberger, Korbinian, Finnegan, E Jean, Turck, Franziska, Goodrich, Justin

“…The Polycomb group (PcG) and trithorax group (trxG) genes play crucial roles in development by regulating expression of homeotic and other genes controlling…”
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Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere by Verzijlbergen, Kitty F, Nerusheva, Olga O, Kelly, David, Kerr, Alastair, Clift, Dean, de Lima Alves, Flavia, Rappsilber, Juri, Marston, Adele L

“…To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles ('biorientation') prior to their segregation during mitosis…”
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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components by Alabert, Constance, Bukowski-Wills, Jimi-Carlo, Lee, Sung-Bau, Kustatscher, Georg, Nakamura, Kyosuke, de Lima Alves, Flavia, Menard, Patrice, Mejlvang, Jakob, Rappsilber, Juri, Groth, Anja

“…To maintain genome function and stability, DNA sequence and its organization into chromatin must be duplicated during cell division. Understanding how entire…”
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RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit by Milligan, Laura, Sayou, Camille, Tuck, Alex, Auchynnikava, Tatsiana, Reid, Jane Ea, Alexander, Ross, Alves, Flavia de Lima, Allshire, Robin, Spanos, Christos, Rappsilber, Juri, Beggs, Jean D, Kudla, Grzegorz, Tollervey, David

“…Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with…”
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Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification by Buscaino, Alessia, White, Sharon A, Houston, Douglas R, Lejeune, Erwan, Simmer, Femke, de Lima Alves, Flavia, Diyora, Piyush T, Urano, Takeshi, Bayne, Elizabeth H, Rappsilber, Juri, Allshire, Robin C

“…Non-coding transcription can trigger histone post-translational modifications forming specialized chromatin. In fission yeast, heterochromatin formation…”
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Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit by Vagnarelli, Paola, Ribeiro, Susana, Sennels, Lau, Sanchez-Pulido, Luis, de Lima Alves, Flavia, Verheyen, Toon, Kelly, David A., Ponting, Chris P., Rappsilber, Juri, Earnshaw, William C.

“…Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome structure during mitotic exit. Here, we show that a…”
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Tissue-specific control of brain-enriched miR-7 biogenesis by Choudhury, Nila Roy, de Lima Alves, Flavia, de Andrés-Aguayo, Luisa, Graf, Thomas, Cáceres, Javier F, Rappsilber, Juri, Michlewski, Gracjan

“…MicroRNA (miRNA) biogenesis is a highly regulated process in eukaryotic cells. Several mature miRNAs exhibit a tissue-specific pattern of expression without an…”
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Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore by Samejima, Itaru, Spanos, Christos, Alves, Flavia de Lima, Hori, Tetsuya, Perpelescu, Marinela, Zou, Juan, Rappsilber, Juri, Fukagawa, Tatsuo, Earnshaw, William C

“…Kinetochores orchestrate mitotic chromosome segregation. Here, we use quantitative mass spectrometry of mitotic chromosomes isolated from a comprehensive set…”
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Sister kinetochores are mechanically fused during meiosis I in yeast by Sarangapani, Krishna K., Duro, Eris, Deng, Yi, de Lima Alves, Flavia, Ye, Qiaozhen, Opoku, Kwaku N., Ceto, Steven, Rappsilber, Juri, Corbett, Kevin D., Biggins, Sue, Marston, Adèle L., Asbury, Charles L.

“…Production of healthy gametes requires a reductional meiosis I division in which replicated sister chromatids comigrate, rather than separate as in mitosis or…”
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Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization by Kirino, Yohei, Vourekas, Anastassios, Sayed, Nabil, de Lima Alves, Flavia, Thomson, Travis, Lasko, Paul, Rappsilber, Juri, Jongens, Thomas A, Mourelatos, Zissimos

“…Piwi proteins such as Drosophila Aubergine (Aub) and mouse Miwi are essential for germline development and for primordial germ cell (PGC) specification. They…”
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Limits of life in MgCl₂-containing environments: chaotropicity defines the window by Hallsworth, John E, Yakimov, Michail M, Golyshin, Peter N, Gillion, Jenny L.M, D'Auria, Giuseppe, de Lima Alves, Flavia, La Cono, Violetta, Genovese, Maria, McKew, Boyd A, Hayes, Sandra L, Harris, Gayle, Giuliano, Laura, Timmis, Kenneth N, McGenity, Terry J

“…The biosphere of planet Earth is delineated by physico-chemical conditions that are too harsh for, or inconsistent with, life processes and maintenance of the…”
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Arginine Methylation of Vasa Protein Is Conserved across Phyla by Kirino, Yohei, Vourekas, Anastassios, Kim, Namwoo, de Lima Alves, Flavia, Rappsilber, Juri, Klein, Peter S., Jongens, Thomas A., Mourelatos, Zissimos

“…Recent studies have uncovered an unexpected relationship between factors that are essential for germline development in Drosophila melanogaster: the arginine…”
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Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis by Borek, Weronika E., Groocock, Lynda M., Samejima, Itaru, Zou, Juan, de Lima Alves, Flavia, Rappsilber, Juri, Sawin, Kenneth E.

“…Microtubule nucleation is highly regulated during the eukaryotic cell cycle, but the underlying molecular mechanisms are largely unknown. During mitosis in…”
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STING nuclear partners contribute to innate immune signaling responses by Dixon, Charles R., Malik, Poonam, de las Heras, Jose I., Saiz-Ros, Natalia, de Lima Alves, Flavia, Tingey, Mark, Gaunt, Eleanor, Richardson, A. Christine, Kelly, David A., Goldberg, Martin W., Towers, Greg J., Yang, Weidong, Rappsilber, Juri, Digard, Paul, Schirmer, Eric C.

“…STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although…”
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A Genetic Engineering Solution to the “Arginine Conversion Problem” in Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) by Bicho, Claudia C., de Lima Alves, Flavia, Chen, Zhuo A., Rappsilber, Juri, Sawin, Kenneth E.

“…Stable isotope labeling by amino acids in cell culture (SILAC) provides a straightforward tool for quantitation in proteomics. However, one problem associated…”
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Supraspliceosomes at defined functional states portray the pre-assembled nature of the pre-mRNA processing machine in the cell nucleus by Kotzer-Nevo, Hani, de Lima Alves, Flavia, Rappsilber, Juri, Sperling, Joseph, Sperling, Ruth

“…When isolated from mammalian cell nuclei, all nuclear pre-mRNAs are packaged in multi-subunit large ribonucleoprotein complexes-supraspliceosomes-composed of…”
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Rrp5 Binding at Multiple Sites Coordinates Pre-rRNA Processing and Assembly by Lebaron, Simon, Segerstolpe, Åsa, French, Sarah L., Dudnakova, Tatiana, de lima Alves, Flavia, Granneman, Sander, Rappsilber, Juri, Beyer, Ann L., Wieslander, Lars, Tollervey, David

“…In vivo UV crosslinking identified numerous preribosomal RNA (pre-rRNA) binding sites for the large, highly conserved ribosome synthesis factor Rrp5…”
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Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor by Lyst, Matthew J, Ekiert, Robert, Ebert, Daniel H, Merusi, Cara, Nowak, Jakub, Selfridge, Jim, Guy, Jacky, Kastan, Nathaniel R, Robinson, Nathaniel D, de Lima Alves, Flavia, Rappsilber, Juri, Greenberg, Michael E, Bird, Adrian

“…In this study, the authors show that MeCP2 interacts with the NCoR/SMRT co-repressor complex and that a discrete cluster of Rett syndrome–causing mutations in…”
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A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast by Bayne, Elizabeth H, Bijos, Dominika A, White, Sharon A, de Lima Alves, Flavia, Rappsilber, Juri, Allshire, Robin C

“…Heterochromatin plays important roles in the regulation and stability of eukaryotic genomes. Both heterochromatin components and pathways that promote…”
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