Search Results - "de Kruijf, Esther M."

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis by Zhang, Long, Zhou, Fangfang, García de Vinuesa, Amaya, de Kruijf, Esther M., Mesker, Wilma E., Hui, Li, Drabsch, Yvette, Li, Yihao, Bauer, Andreas, Rousseau, Adrien, Sheppard, Kelly-Ann, Mickanin, Craig, Kuppen, Peter J.K., Lu, Chris X., ten Dijke, Peter

“…TGF-β signaling is a therapeutic target in advanced cancers. We identified tumor necrosis factor receptor-associated factor 4 (TRAF4) as a key component…”
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Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer by Mieog, J Sven D, de Kruijf, Esther M, Bastiaannet, Esther, Kuppen, Peter Jk, Sajet, Anita, de Craen, Anton Jm, Smit, Vincent Thbm, van de Velde, Cornelis Jh, Liefers, Gerrit-Jan

“…The purpose of this study was to compare the expression and the prognostic effect of the breast cancer stem cell marker aldehyde dehydrogenase-1 (ALDH1) in…”
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HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients by de Kruijf, Esther M, Sajet, Anita, van Nes, Johanna G H, Natanov, Russ, Putter, Hein, Smit, Vincent T H B M, Liefers, Gerrit Jan, van den Elsen, Peter J, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Nonclassical HLAs, HLA-E and HLA-G, are known to affect clinical outcome in various tumor types. We examined the clinical impact of HLA-E and HLA-G expression…”
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The prognostic value of tumor–stroma ratio in tumor‐positive axillary lymph nodes of breast cancer patients by Vangangelt, Kiki M.H., Tollenaar, Lisanne S.A., van Pelt, Gabi W., de Kruijf, Esther M., Dekker, Tim J.A., Kuppen, Peter J.K., Tollenaar, Rob A.E.M., Mesker, Wilma E.

“…The tumor–stroma ratio (TSR) has previously been found to be a strong prognostic parameter in primary breast cancer tumors. Since the presence of tumor cells…”
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NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study by de Kruijf, Esther M, Sajet, Anita, van Nes, Johanna G H, Putter, Hein, Smit, Vincent T H B M, Eagle, Robert A, Jafferji, Insiya, Trowsdale, John, Liefers, Gerrit Jan, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Cell surface NKG2D ligands (NKG2DL) bind to the activating NKG2D receptor present on NK cells and subsets of T cells, thus playing a role in initiating an…”
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Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner by Kocatürk, Begüm, Van den Berg, Yascha W., Tieken, Chris, Mieog, J. Sven D., de Kruijf, Esther M., Engels, Charla C., van der Ent, Martijn A., Kuppen, Peter J., Van de Velde, Cornelis J., Ruf, Wolfram, Reitsma, Pieter H., Osanto, Susanne, Liefers, Gerrit-Jan, Bogdanov, Vladimir Y., Versteeg, Henri H.

“…Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical…”
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The Predictive Value of HLA Class I Tumor Cell Expression and Presence of Intratumoral Tregs for Chemotherapy in Patients with Early Breast Cancer by DE KRUIJF, Esther M, VAN NES, Johanna G. H, KUPPEN, Peter J. K, SAJET, Anita, TUMMERS, Quirijn R. J. G, PUTTER, Hein, OSANTO, Susanne, SPEETJENS, Frank M, SMIT, Vincent T. H. B. M, JAN LIEFERS, Gerrit, VAN DE VELDE, Cornelis J. H

“…Purpose: We hypothesized that T-cell immune interaction affects tumor development and thus clinical outcome. Therefore, we examined the clinical impact of…”
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Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor–positive early breast cancer patients by van Nes, Johanna G. H., de Kruijf, Esther M., Putter, Hein, Faratian, Dana, Munro, Alison, Campbell, Fiona, Smit, Vincent T. H. B. M., Liefers, Gerrit-Jan, Kuppen, Peter J. K., van de Velde, Cornelis J. H., Bartlett, John M. S.

“…Epithelial mesenchymal transition (EMT) plays an important role in the development of metastases. One of the hallmarks of EMT is loss of E-cadherin and gain of…”
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Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients by de Kruijf, Esther M., van Nes, Johanna G. H., van de Velde, Cornelis J. H., Putter, Hein, Smit, Vincent T. H. B. M., Liefers, Gerrit Jan, Kuppen, Peter J. K., Tollenaar, Rob A. E. M., Mesker, Wilma E.

“…Stroma tissue surrounding cancer cells plays an important role in tumor development and behavior. In colorectal cancer, it has been found that the amount of…”
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COX2 expression in prognosis and in prediction to endocrine therapy in early breast cancer patients by van Nes, Johanna G. H, de Kruijf, Esther M, Faratian, Dana, van de Velde, Cornelis J. H, Putter, Hein, Falconer, Claire, Smit, Vincent T. H. B. M, Kay, Charlene, van de Vijver, Marc J, Kuppen, Peter J. K, Bartlett, John M. S

“…In breast cancer, the prognostic impact of COX2 expression varies widely between studies. We examined the prognostic value of COX2 expression in a large cohort…”
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Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10 by Huijts, Petra E A, van Dongen, Minka, de Goeij, Moniek C M, van Moolenbroek, Adrian J, Blanken, Freek, Vreeswijk, Maaike P G, de Kruijf, Esther M, Mesker, Wilma E, van Zwet, Erik W, Tollenaar, Rob A E M, Smit, Vincent T H B M, van Asperen, Christi J, Devilee, Peter

“…SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are…”
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Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study by van Hoesel, Anneke Q., van de Velde, Cornelis J. H., Kuppen, Peter J. K., Liefers, Gerrit Jan, Putter, Hein, Sato, Yusuke, Elashoff, David A., Turner, Roderick R., Shamonki, Jaime M., de Kruijf, Esther M., van Nes, Johanna G. H., Giuliano, Armando E., Hoon, Dave S. B.

“…Long interspersed element 1 (LINE-1), a non-coding genomic repeat sequence, methylation status can influence tumor progression. In this study, the clinical…”
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High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients by Derr, Remco S, van Hoesel, Anneke Q, Benard, Anne, Goossens-Beumer, Inès J, Sajet, Anita, Dekker-Ensink, N Geeske, de Kruijf, Esther M, Bastiaannet, Esther, Smit, Vincent T H B M, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We…”
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Comparison of frequencies and prognostic effect of molecular subtypes between young and elderly breast cancer patients by de Kruijf, Esther M., Bastiaannet, Esther, Rubertá, Francesca, de Craen, Anton J.M., Kuppen, Peter J.K., Smit, Vincent T.H.B.M., van de Velde, Cornelis J.H., Liefers, Gerrit Jan

“…To compare the distribution and prognostic effect of the breast cancer molecular subtypes in young and elderly breast cancer patients. Our study population…”
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The prognostic value of apoptotic and proliferative markers in breast cancer by Engels, Charla C., Ruberta, Francesca, de Kruijf, Esther M., van Pelt, Gabi W., Smit, Vincent T. H. B. M., Liefers, Gerrit Jan, Matsushima, Tomoko, Shibayama, Masaki, Ishihara, Hideki, van de Velde, Cornelis J. H., Kuppen, Peter J. K.

“…Increasing ability of early breast cancer (BC) diagnosis leading to more early stage detection, better survival, and low relapse marks one of the milestones…”
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Tumor immune subtypes distinguish tumor subclasses with clinical implications in breast cancer patients by de Kruijf, Esther M., Engels, Charla C., van de Water, Willemien, Bastiaannet, Esther, Smit, Vincent T. H. B. M., van de Velde, Cornelis J. H., Liefers, Gerrit Jan, Kuppen, Peter J. K.

“…There is strong evidence that the host’s cellular immune response is linked to tumor progression, however its impact on patient outcome in breast cancer is…”
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Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer by van Hoesel, Anneke Q., van de Velde, Cornelis J. H., Kuppen, Peter J. K., Putter, Hein, de Kruijf, Esther M., van Nes, Johanna G. H., Giuliano, Armando E., Hoon, Dave S. B.

“…Breast cancer patients with similar clinical stage may experience different disease outcomes. Aberrant DNA methylation of primary breast tumors can have impact…”
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Alternatively spliced tissue factor promotes breast cancer growth in a [Beta]1 integrin-dependent manner by Kocatürk, Begüm, Van den Berg, Yascha W, Tieken, Chris, Mieog, J Sven D, de Kruijf, Esther M, Engels, Charla C, vander Ent, Martijn A, Kuppen, Peter J, Van de Velde, Cornelis J, Ruf, Wolfram, Reitsma, Pieter H, Osanto, Susanne, Liefers, Gerrit-Jan, Bogdanov, Vladimir Y, Versteeg, Henri H

“…Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical…”
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Abstract 5184: Age interactions in the prognostic value of ALDH1 for clinical outcome in breast cancer by De Kruijf, Esther M., Mieog, Sven J. D., Bastiaannet, Esther, Kuppen, Peter J. K., Sajet, Anita, Smit, Vincent T.H.B.M., van de Velde, Cornelis J.H., Liefers, Gerrit Jan

“…Introduction: Breast cancer is increasingly becoming a disease affecting older women. Clinicopathological characteristics, such as tumor size and hormone…”
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Abstract 5317: HLA-E and HLA-G tumor expression is of prognostic value for clinical outcome of early breast cancer patients, but exclusively in classical HLA class I tumor-negative patients by de Kruijf, Esther M., Sajet, Anita, van Nes, Johanna Gh, Natanov, Russ, Putter, Hein, Smit, Vincent Thbm, Liefers, Gerrit Jan, van den Elsen, Peter J., van de Velde, Cornelis Jh, Kuppen, Peter Jk

“…Background Non-classical human leukocyte antigens (HLA), HLA-E and HLA-G, are known to affect clinical outcome in various tumor types. We examined the clinical…”
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