Search Results - "de Koning, Eelco J.P."

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data by Grün, Dominic, Muraro, Mauro J., Boisset, Jean-Charles, Wiebrands, Kay, Lyubimova, Anna, Dharmadhikari, Gitanjali, van den Born, Maaike, van Es, Johan, Jansen, Erik, Clevers, Hans, de Koning, Eelco J.P., van Oudenaarden, Alexander

“…Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout the life of an organism. Knowing the identity of the stem cell…”
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Generation of L Cells in Mouse and Human Small Intestine Organoids by PETERSEN, Natalia, REIMANN, Frank, BARTFELD, Sina, FARIN, Henner F, RINGNALDA, Femke C, VRIES, Robert G. J, VAN DEN BRINK, Stieneke, CLEVERS, Hans, GRIBBLE, Fiona M, DE KONING, Eelco J. P

“…Upon a nutrient challenge, L cells produce glucagon-like peptide 1 (GLP-1), a powerful stimulant of insulin release. Strategies to augment endogenous GLP-1…”
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Targeting development of incretin-producing cells increases insulin secretion by Petersen, Natalia, Reimann, Frank, van Es, Johan H, van den Berg, Bernard M, Kroone, Chantal, Pais, Ramona, Jansen, Erik, Clevers, Hans, Gribble, Fiona M, de Koning, Eelco J P

“…Glucagon-like peptide-1-based (GLP-1-based) therapies improve glycemic control in patients with type 2 diabetes. While these agents augment insulin secretion,…”
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KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas by Roost, Matthias S., van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P., Arindrarto, Wibowo, Devalla, Harsha D., Passier, Robert, Mummery, Christine L., Carlotti, Françoise, de Koning, Eelco J.P., van Zwet, Erik W., Goeman, Jelle J., Chuva de Sousa Lopes, Susana M.

“…Differentiated derivatives of human pluripotent stem cells in culture are generally phenotypically immature compared to their adult counterparts. Their…”
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Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection by SCHULTE, Barbara M, LANKE, Kjerstin H. W, GALAMA, Jochem M, ADEMA, Gosse J, VAN KUPPEVELD, Frank J. M, PIGANELLI, Jon D, KERS-REBEL, Esther D, BOTTINO, Rita, TRUCCO, Massimo, HUIJBENS, Richard J. F, RADSTAKE, Timothy R. D. J, ENGELSE, Marten A, DE KONING, Eelco J. P

“…Enteroviruses of the human enterovirus B species (HEV-Bs) (e.g., coxsackie B viruses [CVBs] and echoviruses) have been implicated as environmental factors that…”
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Thiazolidinediones and Blood Lipids in Type 2 Diabetes by van Wijk, Jeroen P.H, de Koning, Eelco J.P, Martens, Edwin P, Rabelink, Ton J

“…ABSTRACT—We evaluated study population characteristics and treatment effects on blood lipids between studies in which either rosiglitazone (RSG) or…”
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A Single-Cell Transcriptome Atlas of the Human Pancreas by Muraro, Mauro J, Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A, Carlotti, Francoise, de Koning, Eelco J P, van Oudenaarden, Alexander

“…To understand organ function, it is important to have an inventory of its cell types and of their corresponding marker genes. This is a particularly…”
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Endothelial Progenitor Cells: More Than an Inflammatory Response? by Rabelink, Ton J, de Boer, Hetty C, de Koning, Eelco J.P, van Zonneveld, Anton-Jan

“…ABSTRACT—The formation of new capillaries (angiogenesis) may be of clinical importance in facilitating reperfusion and regeneration of hibernating cardiac…”
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Rosiglitazone Improves Postprandial Triglyceride and Free Fatty Acid Metabolism in Type 2 Diabetes by van Wijk, Jeroen P.H, de Koning, Eelco J.P, Castro Cabezas, Manuel, Rabelink, Ton J

“…OBJECTIVE:--Increased postprandial lipemia is part of diabetic dyslipidemia and is associated with accelerated atherosclerosis. We investigated the effects of…”
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Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop by Rickels, Michael R, Stock, Peter G, de Koning, Eelco J.P, Piemonti, Lorenzo, Pratschke, Johann, Alejandro, Rodolfo, Bellin, Melena D, Berney, Thierry, Choudhary, Pratik, Johnson, Paul R, Kandaswamy, Raja, Kay, Thomas W.H, Keymeulen, Bart, Kudva, Yogish C, Latres, Esther, Langer, Robert M, Lehmann, Roger, Ludwig, Barbara, Markmann, James F, Marinac, Marjana, Odorico, Jon S, Pattou, François, Senior, Peter A, Shaw, James A.M, Vantyghem, Marie-Christine, White, Steven

“…ABSTRACTβ-cell replacement therapy, available currently as pancreas or islet transplantation, has developed without a clear definition of graft functional and…”
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Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells by SIEBE SPIJKER, H, RAVELLI, Raimond B. G, MUMMERY, Christine L, CARLOTTI, Françoise, DE KONING, Eelco J. P, MIEKE MOMMAAS-KIENHUIS, A, VAN APELDOORN, Aart A, ENGELSE, Marten A, ZALDUMBIDE, Arnaud, BONNER-WEIR, Susan, RABELINK, Ton J, HOEBEN, Rob C, CLEVERS, Hans

“…Conversion of one terminally differentiated cell type into another (or transdifferentiation) usually requires the forced expression of key transcription…”
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RVCL-S and CADASIL display distinct impaired vascular function by de Boer, Irene, Stam, Anine H, Buntinx, Linde, Zielman, Ronald, van der Steen, Iris, van den Maagdenberg, Arn M.J.M, de Koning, Eelco J.P, Ferrari, Michel D, de Hoon, Jan N, Terwindt, Gisela M

“…OBJECTIVEWe aimed to evaluate the role of endothelial-dependent and endothelial-independent vascular reactivity in retinal vasculopathy with cerebral…”
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Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential by Loomans, Cindy J.M., Williams Giuliani, Nerys, Balak, Jeetindra, Ringnalda, Femke, van Gurp, Léon, Huch, Meritxell, Boj, Sylvia F., Sato, Toshiro, Kester, Lennart, de Sousa Lopes, Susana M. Chuva, Roost, Matthias S., Bonner-Weir, Susan, Engelse, Marten A., Rabelink, Ton J., Heimberg, Harry, Vries, Robert G.J., van Oudenaarden, Alexander, Carlotti, Françoise, Clevers, Hans, de Koning, Eelco J.P.

“…Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D…”
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Decline in Pancreas Transplantation Numbers is Accompanied with Lower Publication Rates by Benjamens, Stan, Margreiter, Christian, de Koning, Eelco J.P, Leuvenink, Henri G.D, Pol, Robert A

“…INTRODUCTIONAfter several years of growth in many pancreas transplant programs, the United Network for Organ Sharing (UNOS) database reports a decline in…”
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DNA Methylation Landscapes of Human Fetal Development by Slieker, Roderick C, Roost, Matthias S, van Iperen, Liesbeth, Suchiman, H Eka D, Tobi, Elmar W, Carlotti, Françoise, de Koning, Eelco J P, Slagboom, P Eline, Heijmans, Bastiaan T, Chuva de Sousa Lopes, Susana M

“…Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human…”
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Structure-guided design of selective Epac1 and Epac2 agonists by Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N, Hadders, Michael A, Wienk, Hans, Ellenbroek, Johanne H, de Koning, Eelco J P, Bos, Johannes L, Herberg, Friedrich W, Genieser, Hans-Gottfried, Janssen, Richard A J, Rehmann, Holger

“…The second messenger cAMP is known to augment glucose-induced insulin secretion. However, its downstream targets in pancreatic β-cells have not been…”
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Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular complications of type 1 diabetes by LOOMANS, Cindy J. M, DE KONING, Eelco J. P, STAAL, Frank J. T, ROOKMAAKER, Maarten B, VERSEYDEN, Caroline, DE BOER, Hetty C, VERHAAR, Marianne C, BRAAM, Branko, RABELINK, Ton J, VAN ZONNEVELD, Anton-Jan

“…Type 1 diabetes is associated with reduced vascular repair, as indicated by impaired wound healing and reduced collateral formation in ischemia. Recently,…”
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A High Cell‐Bearing Capacity Multibore Hollow Fiber Device for Macroencapsulation of Islets of Langerhans by Skrzypek, Katarzyna, Groot Nibbelink, Milou, Liefers‐Visser, Jolanda, Smink, Alexandra M., Stoimenou, Eleftheria, Engelse, Marten A., Koning, Eelco J. P., Karperien, Marcel, Vos, Paul, Apeldoorn, Aart, Stamatialis, Dimitrios

“…Macroencapsulation of islets of Langerhans is a promising strategy for transplantation of insulin‐producing cells in the absence of immunosuppression to treat…”
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The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway by 'T HART, Leen M, FRITSCHE, Andreas, PALMER, Colin N. A, VAN HAEFTEN, Timon W, HERZBERG-SCHÄFER, Silke A, SIMONIS-BIK, Annemarie M. C, HOUWING-DUISTERMAAT, Jeanine J, HELMER, Quinta, DEELEN, Joris, GUIGAS, Bruno, HANSEN, Torben, MACHICAO, Fausto, NIJPELS, Giel, WILLEMSEN, Gonneke, HEINE, Robert J, KRAMER, Mark H. H, HOLST, Jens J, DE KONING, Eelco J. P, HÄRING, Hans-Ulrich, PEDERSEN, Oluf, GROOP, Leif, DE GEUS, Eco J. C, SLAGBOOM, P. Eline, VAN LEEUWEN, Nienke, BOOMSMA, Dorret I, EEKHOFF, Elisabeth M. W, PEARSON, Ewan R, DIAMANT, Michaela, DONNELLY, Louise A, DEKKER, Jacqueline M, ALSSEMA, Marjan, FADISTA, Joao, CARLOTTI, Françoise, GJESING, Anette P

“…The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances β-cell function. GLP-1 receptor agonists (GLP-1 RAs) and…”
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Reimagining care for young adults living with type 1 diabetes by Morrissey, Eimear C, Dinneen, Sean F, Lowry, Michelle, de Koning, Eelco JP, Kunneman, Marleen

“…Young adults living with type 1 diabetes often struggle to achieve what clinicians consider to be optimal levels of metabolic control. Despite the impact that…”
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