Search Results - "de Graff, Adam M.R."

Protein Unfolding under Force: Crack Propagation in a Network by de Graff, Adam M.R., Shannon, Gareth, Farrell, Daniel W., Williams, Philip M., Thorpe, M.F.

“…The mechanical unfolding of a set of 12 proteins with diverse topologies is investigated using an all-atom constraint-based model. Proteins are represented as…”
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Highly Charged Proteins: The Achilles' Heel of Aging Proteomes by de Graff, Adam M.R., Hazoglou, Michael J., Dill, Ken A.

“…As cells and organisms age, their proteins sustain increasing amounts of oxidative damage. It is estimated that half of all proteins are damaged in old…”
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Proteostasis collapse is a driver of cell aging and death by Santra, Mantu, Dill, Ken A., de Graff, Adam M. R.

“…What molecular processes drive cell aging and death? Here, we model how proteostasis—i.e., the folding, chaperoning, and maintenance of protein…”
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Highly Charged Proteins are the Achilles' Heel of Aging Proteomes by de Graff, Adam M.R., Hazoglou, Michael J., Dill, Ken A.

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Role of Proteome Physical Chemistry in Cell Behavior by Ghosh, Kingshuk, de Graff, Adam M. R, Sawle, Lucas, Dill, Ken A

“…We review how major cell behaviors, such as bacterial growth laws, are derived from the physical chemistry of the cell’s proteins. On one hand, cell actions…”
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Proteostasis is adaptive: Balancing chaperone holdases against foldases by de Graff, Adam Mr, Mosedale, David E, Sharp, Tilly, Dill, Ken A, Grainger, David J

“…Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to…”
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Uncovering the intrinsic geometry from the atomic pair distribution function of nanomaterials by Lei, Ming, de Graff, Adam M. R., Thorpe, M. F., Wells, Stephen A., Sartbaeva, Asel

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DNA Bending through Large Angles Is Aided by Ionic Screening by Spiriti, Justin, Kamberaj, Hiqmet, de Graff, Adam M. R, Thorpe, M. F, van der Vaart, Arjan

“…We used adaptive umbrella sampling on a modified version of the roll angle to simulate the bending of DNA dodecamers. Simulations were carried out with the…”
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Crack Propagation on Networks: A Model for Protein Unfolding by de Graff, Adam M.R., Shannon, Gareth, Farrell, Daniel W., Williams, Philip M., Thorpe, Michael F.

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The long-wavelength limit of the structure factor of amorphous silicon and vitreous silica by De Graff, Adam M. R., Thorpe, M. F.

“…Liquids are in thermal equilibrium and have a non‐zero structure factor = = in the long‐wavelength limit where is the number density, is the temperature, is…”
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Hierarchical plasticity from pair distance fluctuations by Menor, S A, de Graff, Adam M R, Thorpe, M F

“…Observations, experiments and simulations often generate large numbers of snapshots of configurations of complex many-body systems. It is important to find…”
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