Search Results - "de Graaff, Wim"

Degenerated Cones in Cultured Human Retinas Can Successfully Be Optogenetically Reactivated by Kamar, Sizar, Howlett, Marcus H C, Klooster, Jan, Graaff, Wim de, Csikós, Tamás, Rabelink, Martijn J W E, Hoeben, Rob C, Kamermans, Maarten

“…Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made…”
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Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice by Holstege, Jan C, de Graaff, Wim, Hossaini, Mehdi, Cano, Sebastian Cardona, Jaarsma, Dick, van den Akker, Eric, Deschamps, Jacqueline

“…Although Hox gene expression has been linked to motoneuron identity, a role of these genes in development of the spinal sensory system remained undocumented…”
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Specific connectivity between photoreceptors and horizontal cells in the zebrafish retina by Klaassen, Lauw J, de Graaff, Wim, van Asselt, Jorrit B, Klooster, Jan, Kamermans, Maarten

“…The functional and morphological connectivity between various horizontal cell (HC) types (H1, H2, H3, and H4) and photoreceptors was studied in zebrafish…”
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Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos by Young, Teddy, Rowland, Jennifer Elizabeth, van de Ven, Cesca, Bialecka, Monika, Novoa, Ana, Carapuco, Marta, van Nes, Johan, de Graaff, Wim, Duluc, Isabelle, Freund, Jean-Noël, Beck, Felix, Mallo, Moises, Deschamps, Jacqueline

“…Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis,…”
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Cdx2 Is Essential for Axial Elongation in Mouse Development by Chawengsaksophak, Kallayanee, de Graaff, Wim, Rossant, Janet, Deschamps, Jacqueline, Beck, Felix, Ruddle, Francis H.

“…Inactivation of Cdx2 leads to preimplantation embryonic lethality. Rescue of the implantation defect by tetraploid fusion established that Cdx2 is necessary…”
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GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability by Lodder, Elisabeth M., De Nittis, Pasquelena, Koopman, Charlotte D., Wiszniewski, Wojciech, Moura de Souza, Carolina Fischinger, Lahrouchi, Najim, Guex, Nicolas, Napolioni, Valerio, Tessadori, Federico, Beekman, Leander, Nannenberg, Eline A., Boualla, Lamiae, Blom, Nico A., de Graaff, Wim, Kamermans, Maarten, Cocciadiferro, Dario, Malerba, Natascia, Mandriani, Barbara, Akdemir, Zeynep Hande Coban, Fish, Richard J., Eldomery, Mohammad K., Ratbi, Ilham, Wilde, Arthur A.M., de Boer, Teun, Simonds, William F., Neerman-Arbez, Marguerite, Sutton, V. Reid, Kok, Fernando, Lupski, James R., Reymond, Alexandre, Bezzina, Connie R., Bakkers, Jeroen, Merla, Giuseppe

“…GNB5 encodes the G protein β subunit 5 and is involved in inhibitory G protein signaling. Here, we report mutations in GNB5 that are associated with heart-rate…”
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Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones by Cenedese, Valentina, de Graaff, Wim, Csikós, Tamás, Poovayya, Mitali, Zoidl, Georg, Kamermans, Maarten

“…Retinal horizontal cells (HCs) feed back negatively to cone photoreceptors and in that way generate the center/surround organization of bipolar cell receptive…”
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M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue by Martins, Ivone M., Lima, Alexandre, de Graaff, Wim, Cristóvão, Joana S., Brosens, Niek, Aronica, Eleonora, Kluskens, Leon D., Gomes, Cláudio M., Azeredo, Joana, Kessels, Helmut W.

“…Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect Aβ-oligomers in brain…”
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GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability by Lodder, Elisabeth M., De Nittis, Pasquelena, Koopman, Charlotte D., Wiszniewski, Wojciech, Moura de Souza, Carolina Fischinger, Lahrouchi, Najim, Guex, Nicolas, Napolioni, Valerio, Tessadori, Federico, Beekman, Leander, Nannenberg, Eline A., Boualla, Lamiae, Blom, Nico A., de Graaff, Wim, Kamermans, Maarten, Cocciadiferro, Dario, Malerba, Natascia, Mandriani, Barbara, Coban Akdemir, Zeynep Hande, Fish, Richard J., Eldomery, Mohammad K., Ratbi, Ilham, Wilde, Arthur A.M., de Boer, Teun, Simonds, William F., Neerman-Arbez, Marguerite, Sutton, V. Reid, Kok, Fernando, Lupski, James R., Reymond, Alexandre, Bezzina, Connie R., Bakkers, Jeroen, Merla, Giuseppe

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Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation by van den Akker, Eric, Forlani, Sylvie, Chawengsaksophak, Kallayanee, de Graaff, Wim, Beck, Felix, Meyer, Barbara I, Deschamps, Jacqueline

“…Mouse Cdx and Hox genes presumably evolved from genes on a common ancestor cluster involved in anteroposterior patterning. Drosophila caudal ( cad ) is…”
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The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice by van Nes, Johan, de Graaff, Wim, Lebrin, Franck, Gerhard, Markus, Beck, Felix, Deschamps, Jacqueline

“…Caudal related homeobox (Cdx) genes have so far been shown to be important for embryonic axial elongation and patterning in several vertebrate species. We have…”
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Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes by Akker, Eric van den, Fromental-Ramain, Catherine, Graaff, Wim de, Le Mouellic, Hervé, Brûlet, Philippe, Chambon, Pierre, Deschamps, Jacqueline

“…We present a detailed study of the genetic basis of mesodermal axial patterning by paralogous group 8 Hox genes in the mouse. The phenotype of Hoxd8…”
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Randomly Inserted and Targeted Hox/Reporter Fusions Transcriptionally Silenced in Polycomb Mutants by de Graaff, Wim, Tomotsune, Daihachiro, Oosterveen, Tony, Takihara, Yoshihiro, Koseki, Haruhiko, Deschamps, Jacqueline

“…Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates…”
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Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice by Kress, C, Vogels, R, De Graaff, W, Bonnerot, C, Meijlink, F, Nicolas, J F, Deschamps, J

“…The mouse Hox-2.3 gene contains an Antp-like homeobox sequence and is expressed in a spatially restricted anteroposterior domain during development. To study…”
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Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice by VOGELS, R, CHARITE, J, DE GRAAFF, W, DESCHAMPS, J

“…The Hox genes have been proved to be instrumental in establishing the positional identity of cells along the embryonic anteroposterior (A-P) axis. Studying the…”
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Specification of multiple vertebral identities by ectopically expressed Hoxb‐8 by Charité, Jeroen, de Graaff, Wim, Deschamps, Jacqueline

“…We have recently generated Hoxb‐8 gain‐of‐function mutant embryos, using a Hoxb‐8 transgene driven by a retinoic acid receptor β2 promoter to extend the…”
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Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development by VOGELS, R, DE GRAAFF, W, DESCHAMPS, J

“…This study reports the expression pattern of the murine homeobox-containing gene Hox-2.3 during development. Using in situ hybridization, we first detect…”
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Hoxb-8 gain-of-function transgenic mice exhibit alterations in the peripheral nervous system by Fanarraga, Mónica L., Charité, Jeroen, Hage, Willem J., Graaff, Wim De, Deschamps, Jacqueline

“…To understand the developmental role of Hoxb-8, this relatively 5′ Hoxb gene was ectopically expressed in embryonic regions where only more 3′ Hox genes are…”
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Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures by Charité, J, de Graaff, W, Shen, S, Deschamps, J

“…Transgenic embryos were generated carrying a Hoxb-8 transgene under control of the mouse RAR beta 2 promoter, which extends the normal expression domain to…”
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Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements by Charité, J, de Graaff, W, Consten, D, Reijnen, M J, Korving, J, Deschamps, J

“…Studies of pattern formation in the vertebrate central nervous system indicate that anteroposterior positional information is generated in the embryo by…”
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