Search Results - "de Crombrugghe, Benoit"
-
1
Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells
Published in Cell reports (Cambridge) (23-10-2014)“…Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their…”
Get full text
Journal Article -
2
Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells
Published in Cell death & disease (21-05-2021)“…The developmental origins of mesenchymal progenitor cells (MPCs) and molecular machineries regulating their fate and differentiation are far from defined owing…”
Get full text
Journal Article -
3
Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification
Published in Biochemical and biophysical research communications (24-02-2012)“…► Conditional ablation of Osterix (Osx) in chondrocytes leads to skeletal defects. ► Osx regulates chondrocyte differentiation and bone growth in growth plate…”
Get full text
Journal Article -
4
Inhibition of Wnt Signaling by the Osteoblast-Specific Transcription Factor Osterix
Published in Proceedings of the National Academy of Sciences - PNAS (13-05-2008)“…The recent identification of the genes responsible for several human genetic diseases affecting bone homeostasis and the characterization of mouse models for…”
Get full text
Journal Article -
5
Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice
Published in PLoS genetics (01-12-2014)“…One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by…”
Get full text
Journal Article -
6
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25
Published in Nature communications (22-03-2011)Get full text
Journal Article -
7
Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors
Published in Human pathology (01-12-2010)“…Summary Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage…”
Get full text
Journal Article -
8
Genetic regulation of bone mass and susceptibility to osteoporosis
Published in Genes & development (15-09-2006)“…Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Twin and family…”
Get full text
Journal Article -
9
The postnatal role of Sox9 in cartilage
Published in Journal of bone and mineral research (01-12-2012)“…Sox9 is an essential transcription factor for the differentiation of the chondrocytic lineage during embryonic development. To test whether Sox9 continues to…”
Get full text
Journal Article -
10
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice
Published in Proceedings of the National Academy of Sciences - PNAS (20-07-2010)“…The transcription factor Osterix (Osx) is required for osteoblast differentiation and bone formation during embryonic development, but it is not known whether…”
Get full text
Journal Article -
11
Transcriptional mechanisms in osteoblast differentiation and bone formation
Published in Trends in genetics (01-08-2003)“…Osteoblasts, the cells responsible for bone formation, differentiate from mesenchymal cells. Here, we discuss transcription factors that are involved in…”
Get full text
Journal Article -
12
Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation
Published in Biochemical and biophysical research communications (18-05-2007)“…We identified a cDNA encoding mouse Tenascin-W (TN-W) upregulated by bone morphogenetic protein (Bmp)2 in ATDC5 osteo-chondroprogenitors. In adult mice, TN-W…”
Get full text
Journal Article -
13
SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters
Published in PloS one (17-09-2014)“…The transcription factor SOX9 plays an essential role in determining the fate of several cell types and is a master factor in regulation of chondrocyte…”
Get full text
Journal Article -
14
A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6
Published in The Journal of biological chemistry (13-01-2017)“…Type II collagen α1 is specific for cartilaginous tissues, and mutations in its gene are associated with skeletal diseases. Its expression has been shown to be…”
Get full text
Journal Article -
15
SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
Published in Development (Cambridge) (15-03-2010)“…SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal…”
Get full text
Journal Article -
16
Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and Odontoblasts
Published in Journal of bone and mineral research (01-06-2018)“…ABSTRACT The Sp7/Osterix transcription factor is essential for bone development. Mutations of the Sp7 gene in humans are associated with craniofacial anomalies…”
Get full text
Journal Article -
17
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons
Published in Genesis (New York, N.Y. : 2000) (01-11-2010)“…Sox9 expression defines cell progenitors in a variety of tissues during mouse embryogenesis. To establish a genetic tool for cell‐lineage tracing and…”
Get full text
Journal Article -
18
SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2007)“…Background & Aims: The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell…”
Get full text
Journal Article -
19
Mesenchyme‐specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation
Published in The FASEB journal (01-06-2015)“…ABSTRACT Previous studies showed that nucleolar protein 66 (NO66), the Jumonji C‐domain‐containing histone demethylase for methylated histone H3K4 and H3K36…”
Get full text
Journal Article -
20
NFAT and Osterix cooperatively regulate bone formation
Published in Nature medicine (01-08-2005)“…Immunosuppressants are crucial in the prevention of detrimental immune reactions associated with allogenic organ transplantation, but they often cause adverse…”
Get full text
Journal Article