Search Results - "de Crombrugghe, Benoit"

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  1. 1

    Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells by Coşkun, Süleyman, Chao, Hsu, Vasavada, Hema, Heydari, Kartoosh, Gonzales, Naomi, Zhou, Xin, de Crombrugghe, Benoit, Hirschi, Karen K.

    Published in Cell reports (Cambridge) (23-10-2014)
    “…Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their…”
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  2. 2

    Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells by Zhou, Xin, Beilter, Allyson, Xu, Zhaohui, Gao, Ruli, Xiong, Shunbin, Paulucci-Holthauzen, Adriana, Lozano, Guillermina, de Crombrugghe, Benoit, Gorlick, Richard

    Published in Cell death & disease (21-05-2021)
    “…The developmental origins of mesenchymal progenitor cells (MPCs) and molecular machineries regulating their fate and differentiation are far from defined owing…”
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  3. 3

    Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification by Oh, Jung-Hoon, Park, Seung-Yoon, de Crombrugghe, Benoit, Kim, Jung-Eun

    “…► Conditional ablation of Osterix (Osx) in chondrocytes leads to skeletal defects. ► Osx regulates chondrocyte differentiation and bone growth in growth plate…”
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  4. 4

    Inhibition of Wnt Signaling by the Osteoblast-Specific Transcription Factor Osterix by Zhang, Chi, Cho, Kyucheol, Huang, Yehong, Lyons, Jon P., Zhou, Xin, Sinha, Krishna, McCrea, Pierre D., de Crombrugghe, Benoit

    “…The recent identification of the genes responsible for several human genetic diseases affecting bone homeostasis and the characterization of mouse models for…”
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  5. 5

    Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice by Zhou, Xin, von der Mark, Klaus, Henry, Stephen, Norton, William, Adams, Henry, de Crombrugghe, Benoit

    Published in PLoS genetics (01-12-2014)
    “…One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by…”
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    Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors by Dancer, Jane Y., MD, Henry, Stephen P., PhD, Bondaruk, Jolanta, PhD, Lee, Sangkyou, PhD, Ayala, Alberto G., MD, de Crombrugghe, Benoit, MD, Czerniak, Bogdan, MD, PhD

    Published in Human pathology (01-12-2010)
    “…Summary Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage…”
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  8. 8

    Genetic regulation of bone mass and susceptibility to osteoporosis by Ralston, Stuart H, de Crombrugghe, Benoit

    Published in Genes & development (15-09-2006)
    “…Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Twin and family…”
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  9. 9

    The postnatal role of Sox9 in cartilage by Henry, Stephen P, Liang, Shoudan, Akdemir, Kadir C, de Crombrugghe, Benoit

    Published in Journal of bone and mineral research (01-12-2012)
    “…Sox9 is an essential transcription factor for the differentiation of the chondrocytic lineage during embryonic development. To test whether Sox9 continues to…”
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  10. 10

    Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice by Zhou, Xin, Zhang, Zhaoping, Feng, Jian Q., Dusevich, Vladmir M., Sinha, Krishna, Zhang, Hua, Darnay, Bryant G., de Crombrugghe, Benoit, Olson, Eric N.

    “…The transcription factor Osterix (Osx) is required for osteoblast differentiation and bone formation during embryonic development, but it is not known whether…”
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  11. 11

    Transcriptional mechanisms in osteoblast differentiation and bone formation by Nakashima, Kazuhisa, de Crombrugghe, Benoit

    Published in Trends in genetics (01-08-2003)
    “…Osteoblasts, the cells responsible for bone formation, differentiate from mesenchymal cells. Here, we discuss transcription factors that are involved in…”
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  12. 12

    Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation by Kimura, Hiroaki, Akiyama, Haruhiko, Nakamura, Takashi, Crombrugghe, Benoit de

    “…We identified a cDNA encoding mouse Tenascin-W (TN-W) upregulated by bone morphogenetic protein (Bmp)2 in ATDC5 osteo-chondroprogenitors. In adult mice, TN-W…”
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  13. 13

    SOX9 regulates multiple genes in chondrocytes, including genes encoding ECM proteins, ECM modification enzymes, receptors, and transporters by Oh, Chun-do, Lu, Yue, Liang, Shoudan, Mori-Akiyama, Yuko, Chen, Di, de Crombrugghe, Benoit, Yasuda, Hideyo

    Published in PloS one (17-09-2014)
    “…The transcription factor SOX9 plays an essential role in determining the fate of several cell types and is a master factor in regulation of chondrocyte…”
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  14. 14

    A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6 by Yasuda, Hideyo, Oh, Chun-do, Chen, Di, de Crombrugghe, Benoit, Kim, Jin-Hoi

    Published in The Journal of biological chemistry (13-01-2017)
    “…Type II collagen α1 is specific for cartilaginous tissues, and mutations in its gene are associated with skeletal diseases. Its expression has been shown to be…”
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  15. 15

    SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification by Hattori, Takako, Müller, Catharina, Gebhard, Sonja, Bauer, Eva, Pausch, Friederike, Schlund, Britta, Bösl, Michael R., Hess, Andreas, Surmann-Schmitt, Cordula, von der Mark, Helga, de Crombrugghe, Benoit, von der Mark, Klaus

    Published in Development (Cambridge) (15-03-2010)
    “…SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal…”
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  16. 16

    Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and Odontoblasts by Bae, Ji‐Myung, Clarke, John C, Rashid, Harunur, Adhami, Mitra D, McCullough, Kayla, Scott, Jordan S, Chen, Haiyan, Sinha, Krishna M, de Crombrugghe, Benoit, Javed, Amjad

    Published in Journal of bone and mineral research (01-06-2018)
    “…ABSTRACT The Sp7/Osterix transcription factor is essential for bone development. Mutations of the Sp7 gene in humans are associated with craniofacial anomalies…”
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  17. 17

    Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons by Soeda, Tsunemitsu, Deng, Jian Min, de Crombrugghe, Benoit, Behringer, Richard R., Nakamura, Takashi, Akiyama, Haruhiko

    Published in Genesis (New York, N.Y. : 2000) (01-11-2010)
    “…Sox9 expression defines cell progenitors in a variety of tissues during mouse embryogenesis. To establish a genetic tool for cell‐lineage tracing and…”
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  18. 18

    SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium by Mori–Akiyama, Yuko, van den Born, Maaike, van Es, Johan H, Hamilton, Stanley R, Adams, Henry P, Zhang, Jiexin, Clevers, Hans, de Crombrugghe, Benoit

    Published in Gastroenterology (New York, N.Y. 1943) (01-08-2007)
    “…Background & Aims: The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell…”
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  19. 19

    Mesenchyme‐specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation by Chen, Qin, Zhang, Liping, Crombrugghe, Benoit, Krahe, Ralf

    Published in The FASEB journal (01-06-2015)
    “…ABSTRACT Previous studies showed that nucleolar protein 66 (NO66), the Jumonji C‐domain‐containing histone demethylase for methylated histone H3K4 and H3K36…”
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  20. 20

    NFAT and Osterix cooperatively regulate bone formation by Takayanagi, Hiroshi, Koga, Takako, Matsui, Yuichi, Asagiri, Masataka, Kodama, Tatsuhiko, de Crombrugghe, Benoit, Nakashima, Kazuhisa

    Published in Nature medicine (01-08-2005)
    “…Immunosuppressants are crucial in the prevention of detrimental immune reactions associated with allogenic organ transplantation, but they often cause adverse…”
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