Search Results - "daSilva, Luis L.P."

Endoplasmic Reticulum Export Sites and Golgi Bodies Behave as Single Mobile Secretory Units in Plant Cells by Luis L. P. da Silva, Snapp, Erik L., Denecke, Jürgen, Lippincott-Schwartz, Jennifer, Hawes, Chris, Brandizzi, Federica

“…In contrast with animals, plant cells contain multiple mobile Golgi stacks distributed over the entire cytoplasm. However, the distribution and dynamics of…”
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Targeting of the Plant Vacuolar Sorting Receptor BP80 Is Dependent on Multiple Sorting Signals in the Cytosolic Tail by daSilva, Luis L. P., Foresti, Ombretta, Denecke, Jurgen

“…Although signals for vacuolar sorting of soluble proteins are well described, we have yet to learn how the plant vacuolar sorting receptor BP80 reaches its…”
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Receptor salvage from the prevacuolar compartment is essential for efficient vacuolar protein targeting by DaSilva, L.L.P, Taylor, J.P, Hadlington, J.L, Hanton, S.L, Snowden, C.J, Fox, S.J, Foresti, O, Brandizzi, F, Denecke, J

“…We have characterized the requirements to inhibit the function of the plant vacuolar sorting receptor BP80 in vivo and gained insight into the crucial role of…”
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Skin cancer treatment effectiveness is improved by iontophoresis of EGFR-targeted liposomes containing 5-FU compared with subcutaneous injection by Petrilli, Raquel, Eloy, Josimar O., Saggioro, Fabiano P., Chesca, Deise L., de Souza, Marina Claro, Dias, Marcos V.S., daSilva, Luis L.P., Lee, Robert J., Lopez, Renata F.V.

“…Squamous cell carcinoma (SCC) is a malignant tumor in which epidermal growth factor receptor (EGFR) overexpression is associated with poor prognosis and…”
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Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex by Burgos, Patricia V., Mardones, Gonzalo A., Rojas, Adriana L., daSilva, Luis L.P., Prabhu, Yogikala, Hurley, James H., Bonifacino, Juan S.

“…Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes…”
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Golgi-Dependent Transport of Vacuolar Sorting Receptors Is Regulated by COPII, AP1, and AP4 Protein Complexes in Tobacco by Gershlick, David C., de Marcos Lousa, Carine, Foresti, Ombretta, Lee, Andrew J., Pereira, Estela A., daSilva, Luis L.P., Bottanelli, Francesca, Denecke, Jurgen

“…The cycling of vacuolar sorting receptors (VSRs) between early and late secretory pathway compartments is regulated by signals in the cytosolic tail, but the…”
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Overexpression of the Arabidopsis Syntaxin PEP12/SYP21 Inhibits Transport from the Prevacuolar Compartment to the Lytic Vacuole in Vivo by Foresti, Ombretta, daSilva, Luis L.P, Denecke, Jürgen

“…Golgi-mediated transport to the lytic vacuole involves passage through the prevacuolar compartment (PVC), but little is known about how vacuolar proteins exit…”
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HIV‐1 Nef: Taking Control of Protein Trafficking by Pereira, Estela A., daSilva, Luis L. P.

“…The Nef protein of the human immunodeficiency virus modifies the surface proteome of infected cells in order to create an optimized environment for viral…”
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Oropouche Virus Glycoprotein Topology and Cellular Requirements for Glycoprotein Secretion by Barbosa, Natalia S, Concha, Juan O, daSilva, Luis L P, Crump, Colin M, Graham, Stephen C

“…Oropouche virus (OROV; genus Orthobunyavirus) is the etiological agent of Oropouche fever, a debilitating febrile illness common in South America. We used…”
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AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter by Tavares, Lucas Alves, Rodrigues, Roger Luiz, Santos da Costa, Cristina, Nascimento, Jonas Alburqueque, Vargas de Carvalho, Julianne, Nogueira de Carvalho, Andreia, Mardones, Gonzalo A., daSilva, Luis L.P.

“…Selective retrograde transport from endosomes back to the trans-Golgi network (TGN) is important for maintaining protein homeostasis, recycling receptors, and…”
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HIV-1 Nef Changes the Proteome of T Cells Extracellular Vesicles Depleting IFITMs and Other Antiviral Factors by da Silva-Januário, Mara E, da Costa, Cristina S, Tavares, Lucas A, Oliveira, Ana K, Januário, Yunan C, de Carvalho, Andreia N, Cassiano, Murilo H A, Rodrigues, Roger L, Miller, Michael E, Palameta, Soledad, Arns, Clarice W, Arruda, Eurico, Paes Leme, Adriana F, daSilva, Luis L P

“…Extracellular vesicles (EVs) are biomolecule carriers for intercellular communication in health and disease. Nef is a HIV virulence factor that is released…”
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Hijacking of endocytosis by HIV-1 Nef is becoming crystal clear by Januário, Yunan C., daSilva, Luis L. P.

“…The cell surface protein CD4 acts as a coreceptor for incoming HIV particles. However, the expression of CD4 in HIV-producing cells is detrimental to virus…”
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Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2 by Clososki, Giuliano, Soldi, Rafael, da Silva, Rodrigo, Guaratini, Thais, Lopes, José, Pereira, Pâmela, Lopes, João, dos Santos, Thiago, Martins, Ronaldo, Costa, Cristina, de Carvalho, Andréia, daSilva, Luis, Arruda, Eurico, Lopes, Norberto

“…The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led society to live with a serious public health problem. In this…”
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Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef by Tavares, Lucas A, de Carvalho, Julianne V, Costa, Cristina S, Silveira, Roberta M, de Carvalho, Andreia N, Donadi, Eduardo A, daSilva, Luis L P

“…The HIV-1 accessory protein Nef downregulates the cell surface expression of major histocompatibility complex class I (MHC-I) molecules to facilitate virus…”
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The K/HDEL receptor does not recycle but instead acts as a Golgi-gatekeeper by Alvim, Jonas C., Bolt, Robert M., An, Jing, Kamisugi, Yasuko, Cuming, Andrew, Silva-Alvim, Fernanda A. L., Concha, Juan O., daSilva, Luis L. P., Hu, Meiyi, Hirsz, Dominique, Denecke, Jurgen

“…Accurately measuring the ability of the K/HDEL receptor (ERD2) to retain the ER cargo Amy-HDEL has questioned earlier results on which the popular receptor…”
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Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments by Januário, Yunan C., Eden, Jessica, de Oliveira, Luan S., De Pace, Raffaella, Tavares, Lucas A., da Silva-Januário, Mara E., Apolloni, Vinícius B., Wilby, Elise L., Altmeyer, Randolf, Burgos, Patricia V., Corrêa, Sonia A.L., Gershlick, David C., daSilva, Luis L.P.

“…One of the hallmarks of Alzheimer’s disease is the accumulation of toxic amyloid-β (Aβ) peptides in extracellular plaques. The direct precursor of Aβ is the…”
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HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity by daSilva, Luis L.P., Mardones, Gonzalo A.

“…Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats…”
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Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection by de Carvalho, Julianne V, de Castro, Rodrigo O, da Silva, Elaine Z M, Silveira, Paola P, da Silva-Januário, Mara E, Arruda, Eurico, Jamur, Maria C, Oliver, Constance, Aguiar, Renato S, daSilva, Luis L P

“…Nef is an HIV-1 accessory protein that promotes viral replication and pathogenesis. A key function of Nef is to ensure sustained depletion of CD4 and MHC-I…”
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Sorting of the Alzheimer' s Disease Amyloid Precursor Protein Mediated by the AP-4 Complex by Burgos, Patricia V, Mardones, Gonzalo A, Rojas, Adriana L, DaSilva, Luis LP, Prabhu, Yogikala, Hurley, James H, Bonifacino, Juan S

“…Adaptor protein 4 (AP-4) is the most recently discovered and least well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes…”
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CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking by Tavares, Lucas A, da Silva, Eulália M L, da Silva-Januário, Mara E, Januário, Yunan C, de Cavalho, Julianne V, Czernisz, Érika S, Mardones, Gonzalo A, daSilva, Luis L P

“…The HIV accessory protein Nef is a major determinant of viral pathogenesis that facilitates viral particle release, prevents viral antigen presentation and…”
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