Studies with emulsion containing trans-resveratrol: in vitro release profile and ex vivo human skin permeation

Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was dev...

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Bibliographic Details
Published in:	Current drug delivery Vol. 12; no. 2; p. 157
Main Authors:	de Almeida, Priscila Aparecida, Alves, Michele Campos, Polonini, Hudson Caetano, Calixto, Stephane Lima, Braga Gomes, Tiago Brum, Barros Lataliza, Alexandre Augusto, da Silveira Ramos, Cristiano Dias, Barbosa Raposo, Nádia Rezende, de Oliveira Ferreira, Anderson, Fernandes Brandão, Antônio
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-01-2015
Subjects:	Administration, Cutaneous Chromatography, High Pressure Liquid - methods Drug Delivery Systems - methods Drug Liberation Emulsions - administration & dosage Emulsions - chemistry Humans In Vitro Techniques Kinetics Permeability Skin Absorption Stilbenes - administration & dosage Stilbenes - pharmacokinetics
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Summary:	Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validated for its determination in transdermal emulsion, as well in receptor media and skin layers. The trans-resveratrol release kinetic followed the Higushi's model (R(2) = 0.9926) with steady-state diffusion flux and lag time of 138.5 µg cm(-2) h(-1) and 0.49 h, respectively. It showed a percentage at 64.96 % for permeation. Thus, the results suggest that the emulsion studied is a potential vehicle for transresveratrol administration by transdermal route.
ISSN:	1875-5704
DOI:	10.2174/1567201812666150130161736