Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances

The purpose of this work was to evaluate the antileishmanial activity of endophytic fungi isolated from leaves of Vernonia polyanthes plant and their prospective use in the discovery of bioactive compounds. Sixteen endophytes were isolated by using potato dextrose agar medium and submitted to cultiv...

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Published in:	World journal of microbiology & biotechnology Vol. 31; no. 11; pp. 1793 - 1800
Main Authors:	do Nascimento, Adriana M, Soares, Mateus Gonçalves, da Silva Torchelsen, Fernanda K. V, de Araujo, Jorge A. Viana, Lage, Paula S, Duarte, Mariana C, Andrade, Pedro H. R, Ribeiro, Tatiana G, Coelho, Eduardo A. F, do Nascimento, Andréa M
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-11-2015 Springer Nature B.V
Subjects:	Agar Analysis Applied Microbiology Ascomycota - chemistry Ascomycota - classification Ascomycota - genetics Bioactive compounds bioactive properties Bioassays Biochemistry Biocompatibility Biological activity Biomedical and Life Sciences Biotechnology Bipolaris sorokiniana Cochliobolus sativus Culture DNA, Fungal - analysis DNA, Ribosomal - analysis Endophytes Endophytes - chemistry Endophytes - classification Endophytes - genetics Environmental Engineering/Biotechnology Ethanol Ethanol - chemistry Ethanol - isolation & purification Ethanol - pharmacology Ethyl alcohol Extraction processes extracts Flowers & plants Fractionation Fungi Herbal medicine internal transcribed spacers Leaves Leishmania - drug effects Life Sciences Medicinal plants Metabolites Microbiology Microorganisms Natural products Original Paper Parasites Phylogenetics Plant diseases Plant Leaves - microbiology Plants (organisms) Plants, Medicinal - microbiology ribosomal RNA rice RNA, Ribosomal - analysis Sequence Analysis, DNA - methods Solanum tuberosum Studies Tropical diseases Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Vernonia Vernonia - microbiology Endophytes Bioprospection Antileishmanial activity Vernonia polyanthes Leishmania amazonensis
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Summary:	The purpose of this work was to evaluate the antileishmanial activity of endophytic fungi isolated from leaves of Vernonia polyanthes plant and their prospective use in the discovery of bioactive compounds. Sixteen endophytes were isolated by using potato dextrose agar medium and submitted to cultivation in rice medium. The fungal cultures were extracted with ethanol and used as crude extracts for testing their antileishmanial activity. The most active ethanol extract was obtained from P2-F3 strain, which was identified as Cochliobolus sativus by ITS rRNA gene sequence data. Followed by a bioassay-guided fractionation, the cochlioquinone A, isocochlioquinone A and anhydrocochlioquinone A compounds were isolated from the crude extracts and demonstrated to inhibit the parasites. From the present work, it is possible to conclude that endophytic fungi derived from medicinal plant V. polyanthes may be considered promising source for the discovery of bioactive compounds.
Bibliography:	http://dx.doi.org/10.1007/s11274-015-1932-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0959-3993 1573-0972
DOI:	10.1007/s11274-015-1932-0