Spirulina platensis Consumption Prevents Obesity and Improves the Deleterious Effects on Intestinal Reactivity in Rats Fed a Hypercaloric Diet

The consumption of hypercaloric diets is related to the development of obesity, favoring the etiology of gastrointestinal disorders. In this context, Spirulina platensis (SP), some blue-green algae with antioxidant action, appears as a potential therapeutic alternative to prevent obesity and associa...

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Bibliographic Details
Published in:	Oxidative medicine and cellular longevity Vol. 2021; no. 1; p. 3260789
Main Authors:	Diniz, Anderson Fellyp Avelino, de Oliveira Claudino, Brena Freire, Duvirgens, Manoel Vieira, da Silva Souza, Petruska Pessoa, Ferreira, Paula Benvindo, Júnior, Francisco Fernandes Lacerda, Alves, Adriano Francisco, da Silva, Bagnólia Araújo
Format:	Journal Article
Language:	English
Published:	United States Hindawi 2021 Hindawi Limited
Subjects:	Algae Animals Antioxidants - pharmacology Calcium Channels - genetics Calcium Channels - metabolism Chloride Diet Diet, High-Fat - adverse effects Dietary Supplements Food Glucose Lipids Liver - drug effects Liver - metabolism Male Metabolites Obesity Obesity - etiology Obesity - metabolism Obesity - pathology Obesity - prevention & control Proteins Rats Rats, Wistar Receptor, Muscarinic M3 - genetics Receptor, Muscarinic M3 - metabolism Rodents Small intestine Sodium Spirulina - chemistry Spirulina - physiology Weight control Brazil
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Summary:	The consumption of hypercaloric diets is related to the development of obesity, favoring the etiology of gastrointestinal disorders. In this context, Spirulina platensis (SP), some blue-green algae with antioxidant action, appears as a potential therapeutic alternative to prevent obesity and associated intestinal disorders. Thus, the present study is aimed at evaluating the deleterious effects of the hypercaloric diet on the contractile and relaxing reactivity of the ileum of rats, as well as the possible preventive mechanisms of dietary supplementation with SP. Wistar rats were divided into three groups: fed a standard diet (SD), a hypercaloric diet (HCD), and/or supplemented with 25 mg/kg SP (HCD+SP25) for 8 weeks. The hypercaloric diet was effective in promoting obesity in rats, as well as decreasing potency and ileal relaxing and contractile efficacy. In contrast, dietary supplementation with SP was able to prevent some of the parameters of experimental obesity. In addition, SP prevented the reduction of intestinal reactivity, possibly due to a positive modulation of voltage-gated calcium channels (CaV) and negative regulation of muscarinic receptors (M3). Thus, food supplementation with Spirulina platensis becomes a promising alternative in the prevention of gastrointestinal diseases induced and/or aggravated by obesity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Kai Wang
ISSN:	1942-0900 1942-0994
DOI:	10.1155/2021/3260789