Examining variations in body composition among patients with colorectal cancer according to site and disease stage

Examining variations in body composition among patients with colorectal cancer according to site and disease stage

Patients with colorectal cancer (CRC) often exhibit changes in body composition (BC) which are associated with poorer clinical outcomes. Many studies group colon and rectal cancers together, irrespective of staging, potentially affecting assessment and treatment strategies. Our study aimed to compar...

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Bibliographic Details
Published in:Scientific reports Vol. 14; no. 1; p. 10829
Main Authors: da Silva Nascimento, Mayra Laryssa, Alves Bennemann, Nithaela, de Sousa, Iasmin Matias, de Oliveira Bezerra, Mara Rubia, Villaça Chaves, Gabriela, Moreira Lima Verde, Sara Maria, Fernandes Maurício, Silvia, Barreto Campello Carvalheira, José, Santos Mendes, Maria Carolina, Miranda, Ana Lucia, da Costa Pereira, Jarson Pedro, Gonzalez, M. Cristina, Prado, Carla M., Fayh, Ana Paula Trussardi
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 11-05-2024
Nature Publishing Group
Nature Portfolio
Subjects:
631/67/322
692/308/174
692/4028
Adipose tissue
Aged
Body Composition
Body Mass Index
Cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - pathology
Female
Humanities and Social Sciences
Humans
Intra-Abdominal Fat
Male
Metastases
Metastasis
Middle Aged
multidisciplinary
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Musculoskeletal system
Neoplasm Staging
Patients
Rectum
Science
Science (multidisciplinary)
Skeletal muscle
Tumors
Variation
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Summary:Patients with colorectal cancer (CRC) often exhibit changes in body composition (BC) which are associated with poorer clinical outcomes. Many studies group colon and rectal cancers together, irrespective of staging, potentially affecting assessment and treatment strategies. Our study aimed to compare BC in patients with CRC focusing on tumor location and metastasis presence. A total of 635 individuals were evaluated, with a mean age of 61.8 ± 12.4 years and 50.2% female. The majority had rectal cancer as the primary cancer site (51.0%), and 23.6% had metastatic disease. The first regression model showed tumor site and metastasis as independent factors influencing skeletal muscle (SM), skeletal muscle index (SMI), and visceral adipose tissue variability (all p values < 0.05). The second model, adjusted for BMI, indicated tumor site as the primary factor affecting SMI variations (adjusted R 2  = 0.50 p  < 0.001), with colon tumors inversely associated with SM (standardized β − 2.15(− 3.3; − 0.9) p  < 0.001). A third model, considering all the confounders from the directed acyclic graphs, was constructed and the found association remained independent. Our findings highlight significant BC variations in patients with CRC, influenced by tumor location and metastases presence, underscoring the need for location-specific assessment in CRC management.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-61790-0