Highly Porous 3D Nanofibrous Scaffold of Polylactic Acid/Polyethylene Glycol/Calcium Phosphate for Bone Regeneration by a Two-Step Solution Blow Spinning (SBS) Facile Route

Highly Porous 3D Nanofibrous Scaffold of Polylactic Acid/Polyethylene Glycol/Calcium Phosphate for Bone Regeneration by a Two-Step Solution Blow Spinning (SBS) Facile Route

This work presents the successful production of highly porous 3D nanofibrous hybrid scaffolds of polylactic acid (PLA)/polyethylene glycol (PEG) blends with the incorporation of calcium phosphate (CaP) bioceramics by a facile two-step process using the solution blow spinning (SBS) technique. CaP nan...

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Bibliographic Details
Published in:Polymers Vol. 16; no. 21; p. 3041
Main Authors: da Silva, Vanderlane Cavalcanti, Gomes, Déborah dos Santos, de Medeiros, Eudes Leonan Gomes, Santos, Adillys Marcelo da Cunha, de Lima, Isabela Lemos, Rosa, Taciane Pedrosa, Rocha, Flaviana Soares, Filice, Leticia de Souza Castro, Neves, Gelmires de Araújo, Menezes, Romualdo Rodrigues
Format: Journal Article
Language:English
Published: Basel MDPI AG 29-10-2024
MDPI
Subjects:
Apatite
Bioceramics
Biocompatibility
Biological activity
Biomedical materials
Biopolymers
Body fluids
Bones
Calcium phosphate
Calcium phosphates
Ceramic fibers
Ceramic materials
Ceramics
Contact angle
Cotton
Differentiation (biology)
hybrid
Hydroxyapatite
In vitro methods and tests
Mechanical properties
Metabolism
Morphology
nanofiber
Nitrates
Osteoblasts
Polyethylene glycol
Polylactic acid
Polymer blends
Polymers
Polyols
Polyvinyl alcohol
Regeneration (physiology)
scaffold
Scaffolds
solution blow spinning
Tissue engineering
Toxicity
Brazil
United States > US
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Summary:This work presents the successful production of highly porous 3D nanofibrous hybrid scaffolds of polylactic acid (PLA)/polyethylene glycol (PEG) blends with the incorporation of calcium phosphate (CaP) bioceramics by a facile two-step process using the solution blow spinning (SBS) technique. CaP nanofibers were obtained at two calcium/phosphorus (Ca/P) ratios, 1.67 and 1.1, by SBS and calcination at 1000 °C. They were incorporated in PLA/PEG blends by SBS at 10 and 20 wt% to form 3D hybrid cotton-wool-like scaffolds. Morphological analysis showed that the fibrous scaffolds obtained had a randomly interconnected and highly porous structure. Also, the mean fiber diameter ranged from 408 ± 141 nm to 893 ± 496 nm. Apatite deposited considerably within 14 days in a simulated body fluid (SBF) test for hybrid scaffolds containing a mix of hydroxyapatite (HAp) and tri-calcium phosphate-β (β-TCP) phases. The scaffolds with 20 wt% CaP and a Ca/P ration of 1.1 showed better in vitro bioactivity to induce calcium mineralization for bone regeneration. Cellular tests evidenced that the developed scaffolds can support the osteogenic differentiation and proliferation of pre-osteoblastic MC3T3-E1 cells into mature osteoblasts. The results showed that the developed 3D scaffolds have potential applications for bone tissue engineering.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym16213041