The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations

Genetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the , , , , , , and genes with the risk of severe forms of COVID-19 in Amazonian Native Americans, and to compare the frequencies with continental populations. The study...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of personalized medicine Vol. 12; no. 4; p. 554
Main Authors:	Pastana, Lucas Favacho, Silva, Thays Amâncio, Gellen, Laura Patrícia Albarello, Vieira, Giovana Miranda, de Assunção, Letícia Almeida, Leitão, Luciana Pereira Colares, da Silva, Natasha Monte, Coelho, Rita de Cássia Calderaro, de Alcântara, Angélica Leite, Vinagre, Lui Wallacy Morikawa Souza, Rodrigues, Juliana Carla Gomes, Borges Leal, Diana Feio da Veiga, Fernandes, Marianne Rodrigues, de Souza, Sandro José, Kroll, José Eduardo, Ribeiro-Dos-Santos, André Mauricio, Burbano, Rommel Mario Rodríguez, Guerreiro, João Farias, de Assumpção, Paulo Pimentel, Ribeiro-Dos-Santos, Ândrea Campos, Dos Santos, Sidney Emanuel Batista, Dos Santos, Ney Pereira Carneiro
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-04-2022 MDPI
Subjects:	ABO system Bioinformatics Blood groups CCR9 protein Coronaviruses COVID-19 Disease Ethics Gene frequency Genes Genetic diversity Genetic engineering Genetic factors Genomes Genomics Immune system Infections Minority & ethnic groups Mutation Pandemics Population Population genetics Population studies Precision medicine United States > US Africa COVID-19 genetic variant gene risk factor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Genetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the , , , , , , and genes with the risk of severe forms of COVID-19 in Amazonian Native Americans, and to compare the frequencies with continental populations. The study population was composed of 64 Amerindians from the Amazon region of northern Brazil. The difference in frequencies between the populations was analyzed using Fisher's exact test, and the results were significant when ≤ 0.05. We investigated 64 polymorphisms in 7 genes; we studied 47 genetic variants that were new or had impact predictions of high, moderate, or modifier. We identified 15 polymorphisms with moderate impact prediction in 4 genes ( , , , and ). Among the variants analyzed, 18 showed significant differences in allele frequency in the NAM population when compared to others. We reported two new genetic variants with modifier impact in the Amazonian population that could be studied to validate the possible associations with COVID-19 outcomes. The genomic profile of Amazonian Native Americans may be associated with protection from severe forms of COVID-19. This work provides genomic data that may help forthcoming studies to improve COVID-19 outcomes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2075-4426 2075-4426
DOI:	10.3390/jpm12040554