Search Results - "da Silva, Meryck Felipe Brito"
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Innovative Multistage ML-QSAR Models for Malaria: From Data to Discovery
Published in ACS medicinal chemistry letters (08-08-2024)“…Malaria presents a significant challenge to global public health, with around 247 million cases estimated to occur annually worldwide. The growing resistance…”
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Multitask learning-driven identification of novel antitrypanosomal compounds
Published in Future medicinal chemistry (01-08-2023)“…Chagas disease and human African trypanosomiasis cause substantial death and morbidity, particularly in low- and middle-income countries, making the need for…”
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Artificial intelligence systems for the design of magic shotgun drugs
Published in Artificial intelligence in the life sciences (01-12-2023)“…Designing magic shotgun compounds, i.e., compounds hitting multiple targets using artificial intelligence (AI) systems based on machine learning (ML) and deep…”
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Hit-to-lead optimization of a pyrazinylpiperazine series against Leishmania infantum and Leishmania braziliensis
Published in European journal of medicinal chemistry (05-08-2023)“…An early hit-to-lead optimization of a novel pyrazinylpiperazine series against L. infantum and L. braziliensis has been performed after an extensive SAR…”
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