Antihypernociceptive activity of anethole in experimental inflammatory pain

Anethole has been reported to have antioxidant, antibacterial, antifungal, antiinflammatory, and anesthetic properties. In the present study, we evaluated the effects of anethole in two pain models of inflammatory origin: acute inflammation induced by carrageenan and persistent inflammation induced...

Full description

Saved in:

Bibliographic Details
Published in:	Inflammopharmacology Vol. 21; no. 2; pp. 187 - 197
Main Authors:	Ritter, Alessandra M. V., Domiciano, Talita P., Verri, Waldiceu A., Zarpelon, Ana Carla, da Silva, Lorena G., Barbosa, Carmem P., Natali, Maria Raquel M., Cuman, Roberto K. N., Bersani-Amado, Ciomar A.
Format:	Journal Article
Language:	English
Published:	Basel SP Birkhäuser Verlag Basel 01-04-2013
Subjects:	Alanine Transaminase - metabolism Allergology Analgesics - adverse effects Analgesics - pharmacology Animals Anisoles - adverse effects Anisoles - pharmacology Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - pharmacology Aspartate Aminotransferases - metabolism Biomedical and Life Sciences Biomedicine Dermatology Edema - chemically induced Edema - drug therapy Edema - metabolism Gastroenterology Illicium - chemistry Immunology Inflammation - drug therapy Inflammation - metabolism Interleukin-17 - metabolism Interleukin-1beta - metabolism Liver - metabolism Male Mice Neutrophils - drug effects Neutrophils - metabolism Nociception - drug effects Oils, Volatile - chemistry Oils, Volatile - pharmacology Pain - drug therapy Pain - metabolism Peroxidase - metabolism Pharmacology/Toxicology Research Article Rheumatology Tumor Necrosis Factor-alpha - metabolism Anethole Hypernociception Oedema Anti-nociceptive activity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Anethole has been reported to have antioxidant, antibacterial, antifungal, antiinflammatory, and anesthetic properties. In the present study, we evaluated the effects of anethole in two pain models of inflammatory origin: acute inflammation induced by carrageenan and persistent inflammation induced by Complete Freund’s adjuvant. We evaluated the effects of anethole (125, 250, and 500 mg/kg) on the development of paw oedema and mechanical hypernociception. The liver was collected for histological analysis. Paw skin was collected to determine the levels of the cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-17 (IL-17), and myeloperoxidase activity. Blood was collected to assess alanine transaminase (ALT) and aspartate transaminase (AST). The chemical composition of star anise oil was determined by gas chromatography/mass spectrometry (GC/MS), showing a presence of anethole of 98.1 %. Oral pretreatment with anethole in mice inhibited paw oedema, mechanical pernociception, myelopewroxidase activity, TNF-α, IL-1β and IL-17 levels in acute and persistent inflammation models. Additionally, anethole treatment did not alter prostaglandin E 2 -induced mechanical hypernociception. Possible side effects were also examined. Seven-day anethole treatment did not alter plasma AST and ALT levels, and the histological profile of liver tissue was normal. The present study provides evidence of the antiinflammatory and analgesic activities of anethole in acute and persistent inflammation models.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0925-4692 1568-5608
DOI:	10.1007/s10787-012-0152-6