Search Results - "da Silva, João Herminio Martins"

Investigation of Unprecedented Sites and Proposition of New Ligands for Programmed Cell Death Protein I through Molecular Dynamics with Probes and Virtual Screening by Andrade, Luca, Albuquerque, Aline, Santos-Costa, Andrielly, Vasconcelos, Disraeli, Savino, Wilson, Sartori, Geraldo Rodrigues, Martins Da Silva, João Herminio

“…Cancer immunotherapy has attracted increasing attention over the last few years. Programmed cell death protein 1 (PD-1) promotes self-tolerance and inhibits…”
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Immunoinformatics-guided design of a multi-valent vaccine against Rotavirus and Norovirus (ChRNV22) by de Oliveira Matos, Amanda, Vilela Rodrigues, Thaís Cristina, Tiwari, Sandeep, dos Santos Dantas, Pedro Henrique, Sartori, Geraldo Rodrigues, de Carvalho Azevedo, Vasco Ariston, Martins Da Silva, João Herminio, de Castro Soares, Siomar, Silva-Sales, Marcelle, Sales-Campos, Helioswilton

“…Rotavirus (RV) and Norovirus (NV) are the main viral etiologic agents of acute gastroenteritis (AG), a serious pediatric condition associated with significant…”
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The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization by de Oliveira Matos, Amanda, dos Santos Dantas, Pedro Henrique, Colmenares, Mike Telemaco Contreras, Sartori, Geraldo Rodrigues, Silva-Sales, Marcelle, Da Silva, João Herminio Martins, Neves, Bruno Junior, Andrade, Carolina Horta, Sales-Campos, Helioswilton

“…The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor heavily investigated in infectious and non-infectious diseases…”
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Structural and molecular modeling features of P2X receptors by Alves, Luiz Anastacio, da Silva, João Herminio Martins, Ferreira, Dinarte Neto Moreira, Fidalgo-Neto, Antonio Augusto, Teixeira, Pedro Celso Nogueira, de Souza, Cristina Alves Magalhães, Caffarena, Ernesto Raúl, de Freitas, Mônica Santos

“…Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two…”
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Polymorphisms in alternative oxidase genes from ecotypes of Arabidopsis and rice revealed an environment‐induced linkage to altitude and rainfall by Thiers, Karine Leitão Lima, da Silva, João Hermínio Martins, Vasconcelos, Disraeli Cavalcante Araújo, Aziz, Shahid, Noceda, Carlos, Arnholdt‐Schmitt, Birgit, Costa, José Hélio

“…We investigated SNPs in alternative oxidase (AOX) genes and their connection to ecotype origins (climate, altitude, and rainfall) by using genomic data sets of…”
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Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika by Mottin, Melina, de Paula Sousa, Bruna Katiele, de Moraes Roso Mesquita, Nathalya Cristina, de Oliveira, Ketllyn Irene Zagato, Noske, Gabriela Dias, Sartori, Geraldo Rodrigues, de Oliveira Albuquerque, Aline, Urbina, Fabio, Puhl, Ana C., Moreira-Filho, José Teófilo, Souza, Guilherme E., Guido, Rafael V. C., Muratov, Eugene, Neves, Bruno Junior, Martins da Silva, João Hermínio, Clark, Alex E., Siqueira-Neto, Jair L., Perryman, Alexander L., Oliva, Glaucius, Ekins, Sean, Andrade, Carolina Horta

“…The Zika virus (ZIKV) is a neurotropic arbovirus considered a global threat to public health. Although there have been several efforts in drug discovery…”
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Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas by Baptista, Barbara Oliveira, de Souza, Ana Beatriz Lopes, Riccio, Evelyn Kety Pratt, Bianco-Junior, Cesare, Totino, Paulo Renato Rivas, Martins da Silva, João Hermínio, Theisen, Michael, Singh, Susheel Kumar, Amoah, Linda Eva, Ribeiro-Alves, Marcelo, Souza, Rodrigo Medeiros, Lima-Junior, Josué Costa, Daniel-Ribeiro, Cláudio Tadeu, Pratt-Riccio, Lilian Rose

“…The GMZ2.6c malaria vaccine candidate is a multi-stage Plasmodium falciparum chimeric protein which contains a fragment of the sexual-stage Pfs48/45-6C protein…”
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Optimization of Resveratrol Used as a Scaffold to Design Histone Deacetylase (HDAC-1 and HDAC-2) Inhibitors by Urias, Beatriz Silva, Pavan, Aline Renata, Albuquerque, Gabriela Ribeiro, Prokopczyk, Igor Muccilo, Alves, Tânia Mara Ferreira, de Melo, Thais Regina Ferreira, Sartori, Geraldo Rodrigues, da Silva, João Hermínio Martins, Chin, Chung Man, Santos, Jean Leandro Dos

“…Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene expression through the deacetylation of histone lysine residues. Therefore,…”
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Development of New Potential Inhibitors of β1 Integrins through In Silico Methods—Screening and Computational Validation by Vasconcelos, Disraeli, Chaves, Beatriz, Albuquerque, Aline, Andrade, Luca, Henriques, Andrielly, Sartori, Geraldo, Savino, Wilson, Caffarena, Ernesto, Martins-Da-Silva, João Herminio

“…Integrins are transmembrane receptors that play a critical role in many biological processes which can be therapeutically modulated using integrin blockers,…”
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In silico Identification and Validation of a Linear and Naturally Immunogenic B-Cell Epitope of the Plasmodium vivax Malaria Vaccine Candidate Merozoite Surface Protein-9 by Rodrigues-da-Silva, Rodrigo Nunes, Martins da Silva, João Hermínio, Singh, Balwan, Jiang, Jianlin, Meyer, Esmeralda V S, Santos, Fátima, Banic, Dalma Maria, Moreno, Alberto, Galinski, Mary R, Oliveira-Ferreira, Joseli, Lima-Junior, Josué da Costa

“…Synthetic peptide vaccines provide the advantages of safety, stability and low cost. The success of this approach is highly dependent on efficient epitope…”
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Polymorphisms in plastoquinol oxidase (PTOX) from Arabidopsis accessions indicate SNP-induced structural variants associated with altitude and rainfall by Thiers, Karine Leitão Lima, da Silva, João Hermínio Martins, Sartori, Geraldo Rodrigues, dos Santos, Clesivan Pereira, Saraiva, Kátia Daniella da Cruz, Roque, André Luiz Maia, Arnholdt-Schmitt, Birgit, Costa, José Hélio

“…Plant plastoquinol oxidase (PTOX) is a chloroplast oxidoreductase involved in carotenoid biosynthesis, chlororespiration, and response to environmental…”
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Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon by de Souza, Hugo Amorim dos Santos, Escafa, Victor Fernandes, Blanco, Carolina Moreira, Baptista, Bárbara de Oliveira, de Barros, Jenifer Peixoto, Riccio, Evelyn Ketty Pratt, Rodrigues, Aline Beatriz Mello, Melo, Gisely Cardoso de, Lacerda, Marcus Vinícius Guimarães de, de Souza, Rodrigo Medeiros, Lima-Junior, Josué da Costa, Guimarães, Ana Carolina Ramos, da Mota, Fabio Faria, da Silva, João Hermínio Martins, Daniel-Ribeiro, Cláudio Tadeu, Pratt-Riccio, Lilian Rose, Totino, Paulo Renato Rivas

“…In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 ( Pv MCA1) catalytic domain in two municipalities of the main…”
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Differential expression of recently duplicated PTOX genes in Glycine max during plant development and stress conditions by Maia, Rachel Alves, da Cruz Saraiva, Kátia Daniella, Roque, André Luiz Maia, Thiers, Karine Leitão Lima, dos Santos, Clesivan Pereira, da Silva, João Hermínio Martins, Feijó, Daniel Ferreira, Arnholdt-Schmitt, Birgit, Costa, José Hélio

“…Plastid terminal oxidase (PTOX) is a chloroplast enzyme that catalyzes oxidation of plastoquinol (PQH 2 ) and reduction of molecular oxygen to water. Its…”
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Plasmodium vivax Cell-Traversal Protein for Ookinetes and Sporozoites: Naturally Acquired Humoral Immune Response and B-Cell Epitope Mapping in Brazilian Amazon Inhabitants by Rodrigues-da-Silva, Rodrigo Nunes, Soares, Isabela Ferreira, Lopez-Camacho, Cesar, Martins da Silva, João Hermínio, Perce-da-Silva, Daiana de Souza, Têva, Antônio, Ramos Franco, Antônia Maria, Pinheiro, Francimeire Gomes, Chaves, Lana Bitencourt, Pratt-Riccio, Lilian Rose, Reyes-Sandoval, Arturo, Banic, Dalma Maria, Lima-Junior, Josué da Costa

“…The cell-traversal protein for ookinetes and sporozoites (CelTOS), a highly conserved antigen involved in sporozoite motility, plays an important role in the…”
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Plasmodium vivax Cell Traversal Protein for Ookinetes and Sporozoites (PvCelTOS) gene sequence and potential epitopes are highly conserved among isolates from different regions of Brazilian Amazon by Bitencourt Chaves, Lana, Perce-da-Silva, Daiana de Souza, Rodrigues-da-Silva, Rodrigo Nunes, Martins da Silva, João Hermínio, Cassiano, Gustavo Capatti, Machado, Ricardo Luiz Dantas, Pratt-Riccio, Lilian Rose, Banic, Dalma Maria, Lima-Junior, Josué da Costa

“…The Plasmodium vivax Cell-traversal protein for ookinetes and sporozoites (PvCelTOS) plays an important role in the traversal of host cells. Although essential…”
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Computationally-obtained structural insights into the molecular interactions between Pidilizumab and binding partners DLL1 and PD-1 by Albuquerque, Aline de Oliveira, da Silva Junior, Haroldo Cid, Sartori, Geraldo Rodrigues, Martins da Silva, João Hermínio

“…Pidilizumab is a monoclonal antibody tested against several types of malignancies, such as lymphoma and metastatic melanoma, showing promising results. In…”
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Antileishmanial drugs activate inflammatory signaling pathways via toll-like receptors (docking approach) from Leishmania amazonensis-infected macrophages by Valentim-Silva, João Rafael, Macedo, Sharon Rose Aragão, de Barros, Neuza Biguinati, dos Santos Ferreira, Amália, da Silva, João Hermínio Martins, de Figueiredo Nicolete, Larissa Deadame, Nicolete, Roberto

“…•AmB, GLU and pent present predicted affinity with different TLRs from L. amazonensis-infected macrophages.•Antileishmanial drugs activate main inflammatory…”
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VLA-4 as a Central Target for Modulating Neuroinflammatory Disorders by Jurberg, Arnon Dias, Chaves, Beatriz, Pinho, Lia Gonçalves, da Silva, João Hermínio Martins, Savino, Wilson, Cotta-de-Almeida, Vinicius

“…The complex steps leading to the central nervous system (CNS) inflammation and the progress to neuroinflammatory and neurodegenerative disorders have opened up…”
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In silico identification of inhibitors of ribose 5-phosphate isomerase from Trypanosoma cruzi using ligand and structure based approaches by de V. C. Sinatti, Vanessa, R. Baptista, Luiz Phillippe, Alves-Ferreira, Marcelo, Dardenne, Laurent, Hermínio Martins da Silva, João, Guimarães, Ana Carolina

“…[Display omitted] •Pharmacophore modeling of ribose 5-phosphate isomerase of Trypanosoma cruzi (TcRpi).•Screening of the ZINC Database, yielding 20,183…”
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In silico mapping of the dynamic interactions and structure-activity relationship of flavonoid compounds against the immune checkpoint programmed-cell death 1 pathway by Sartori, Geraldo Rodrigues, Albuquerque, Aline de Oliveira, Santos-Costa, Andrielly Henriques, Andrade, Luca Milério, Almeida, Diego da Silva, Gaieta, Eduardo Menezes, Sampaio, Jean Vieira, Albuquerque, Vitória Taiana de Melo Lima, Martins Da Silva, João Hermínio

“…Flavonoids are a class of natural products widely available in medicinal and dietary plants. Their pharmacological use has shown the potential to reduce the…”
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