Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities

Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities

We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared...

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Bibliographic Details
Published in:Medicinal chemistry (Shp-sariqah, United Arab Emirates) Vol. 9; no. 8; p. 1085
Main Authors: da Silva, Iara F, Martins, Prisicila R C, da Silva, Emanuelly G, Ferreira, Sabrina B, Ferreira, Vitor F, da Costa, Karen Regina C, de Vasconcellos, Marne C, Lima, Emerson S, da Silva, Fernando de C
Format: Journal Article
Language:English
Published: Netherlands 01-12-2013
Subjects:
Animals
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antifungal Agents - toxicity
Aspergillus niger - drug effects
Candida - drug effects
Dose-Response Relationship, Drug
Fibroblasts - drug effects
Mice
Microbial Sensitivity Tests
Molecular Structure
NIH 3T3 Cells
Structure-Activity Relationship
Triazoles - chemical synthesis
Triazoles - chemistry
Triazoles - pharmacology
Triazoles - toxicity
Trichophyton - drug effects
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Summary:We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.
ISSN:1875-6638
DOI:10.2174/1573406411309080010