Search Results - "da Silva, Fernando C."
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Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications
Published in Chemical record (01-10-2021)“…The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules,…”
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The Antifungal Activity of Naphthoquinones: An Integrative Review
Published in Anais da Academia Brasileira de Ciências (2018)“…Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants,…”
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Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives
Published in Molecules (Basel, Switzerland) (31-03-2020)“…Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After…”
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4
Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones
Published in Anais da Academia Brasileira de Ciências (01-01-2018)“…The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been…”
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5
Plasmodium falciparum Knockout for the GPCR-Like PfSR25 Receptor Displays Greater Susceptibility to 1,2,3-Triazole Compounds That Block Malaria Parasite Development
Published in Biomolecules (Basel, Switzerland) (18-08-2020)“…The search for new compounds with antimalarial activity is urgent, as resistance to ones in the classical drug, has already been described in more than one…”
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α‐ and β‐Lapachone Isomerization in Acidic Media: Insights from Experimental and Implicit/Explicit Solvation Approaches
Published in ChemPlusChem (Weinheim, Germany) (01-01-2019)“…Combined experimental and mixed implicit/explicit solvation approaches were employed to gain insights into the origin of switchable regioselectivity of…”
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Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-01-2021)“…Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases. The aim of this review was to provide an overview of the…”
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Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione)
Published in Current topics in medicinal chemistry (01-01-2020)“…Antibacterial resistance is a serious public health problem infecting millions in the global population. Currently, there are few antimicrobials on the market…”
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9
Design, Synthesis and Antileishmanial Activity of Naphthotriazolyl-4- Oxoquinolines
Published in Current topics in medicinal chemistry (01-01-2018)“…Leishmaniasis is a neglected public health problem caused by several protozoanspecies of the genus Leishmania. The therapeutic arsenal for treating…”
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Alternative Routes to the Click Method for the Synthesis of 1,2,3-Triazoles, an Important Heterocycle in Medicinal Chemistry
Published in Current topics in medicinal chemistry (01-01-2018)“…Heterocyclic rings having nitrogen atoms are the molecular fragments most used in drug design by using the tools of medicinal chemistry. The 1,2,4-triazole…”
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A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties
Published in Current topics in medicinal chemistry (01-01-2018)“…Cancer is a major cause of death worldwide, despite many different drugs available to treat the disease. This high mortality rate is largely due to the…”
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12
Recent advances in the synthesis of new antimycobacterial agents based on the 1H-1,2,3-triazoles
Published in Current topics in medicinal chemistry (01-11-2013)“…The 1H-1,2,3-triazoles have been studied for many years as an important class of heterocyclic compounds and still attracting considerable attention due to…”
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13
Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-12-2013)“…We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr,…”
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14
Magnetic Cationic Copper(II) Chains and a Mononuclear Cobalt(II) Complex Containing [Ln(hfac)4]− Blocks as Counterions
Published in Inorganic chemistry (04-02-2019)“…Four new heterospin compounds with molecular formula {[Cu2(hfac)3(TlTrzNIT)2][Ln(hfac)4]} n ·C7H16 (LnIII = Gd (1), Tb (2), or Dy (3)) and…”
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15
Recent Synthetic Approaches towards Small Molecule Reactivators of p53
Published in Biomolecules (Basel, Switzerland) (20-04-2020)“…The tumor suppressor protein p53 is often called "the genome guardian" and controls the cell cycle and the integrity of DNA, as well as other important…”
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A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis
Published in Current topics in medicinal chemistry (01-01-2018)“…Breast cancer is a major cause of death among women worldwide. Treatment for breast cancer involves the surgical removal of cancer tissue, followed by…”
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Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication
Published in PloS one (20-12-2013)“…Dengue virus infection is a serious public health problem in endemic areas of the world where 2.5 billion people live. Clinical manifestations of the Dengue…”
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18
An Overview of Hydrogen Production from Renewable Sources and Its Main Applications
Published in ChemistrySelect (Weinheim) (18-09-2024)“…There is a misconception that sustainability is only related to greenhouse gas emissions into the atmosphere, and that this is the only risk to which the…”
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Experimental and theoretical evaluation of the anticorrosive proprieties of new 1,2,3-triazolyl-acridine derivatives
Published in Arabian journal of chemistry (01-01-2024)“…Three novel 1,2,3-triazolyl-acridine derivatives (abbreviated as TTA, ATM, and ATA) were synthesized via a fast ultrasound-assisted copper-catalyzed…”
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Synthesis and evaluation of photophysical, electrochemical, and ROS generation properties of new chalcogen-naphthoquinones-1,2,3-triazole hybrids
Published in RSC advances (29-11-2023)“…This study presents a comprehensive analysis encompassing the synthesis, structural elucidation, photophysical behavior, and electrochemical properties of a…”
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