The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead comp...

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Bibliographic Details
Published in:	Marine drugs Vol. 19; no. 5; p. 234
Main Authors:	Stein, Erika M, Tajú, Sara G, Miyasato, Patrícia A, de Freitas, Rafaela P, Tallarico, Lenita de F, Dos Santos, Guilherme S, Luiz, Giovana L F, Rofatto, Henrique K, da Silva, Fábio N V, Colepicolo, Pio, Macedo, Arthur L, Carollo, Carlos A, Nakano, Eliana
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 22-04-2021 MDPI
Subjects:	Alcohols Algae Animal embryos Annotations Biological activity Blastula Control Dictyota diterpenes Eggs Embryos Females Identification Laurencia Laurenciella Lead compounds Males Marine molluscs metabolomic analysis Metabolomics Molluscicides Mollusks Mortality Multivariate analysis Natural products Niclosamide Parasitic diseases Parasitoses Praziquantel Schistosoma mansoni Schistosomiasis Seaweeds sesquiterpenes Shellfish Tropical diseases Veligers Worms Brazil Dictyota GC–MS metabolomic analysis Pattern Hunter test Laurencia Laurenciella Pearson correlation test diterpenes sesquiterpenes
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Summary:	Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against embryos and schistosomicidal activities against . Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC-MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against veliger embryos in the set, 5 hits against blastula embryos, and 31 against in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md19050234